Protein Alignment CG42335 and RNPEP

DIOPT Version :9

• Sequence 1: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_064601.3
• Gene: RNPEP / 6051
• HGNCID: 10078
• Length: 650
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 120/555 - (21%)
• Similarity: 204/555 - (36%)
• Gaps: 132/555 - (23%)

  Fly   156 WLA------------LTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALS 208
            |||            .||.|.:..|...||||.||:|.::...|..|:|:.::.:....|.:  .
Human   152 WLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMSASTWEKR--G 214

  Fly   209 QDRFVDHFKETPVMSTYLLAFMVANYSARGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELF 273
            .::|  .|:....:.:||:|..:.:..:........|...|...|..:..|:...:...|.||..
Human   215 PNKF--FFQMCQPIPSYLIALAIGDLVSAEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKL 277

  Fly   274 QSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHM 338
            ..||.....|:|  ...|.||..||||..|...:..:|..:...:|          :|.||.||.
Human   278 FGPYVWGRYDLL--FMPPSFPFGGMENPCLTFVTPCLLAGDRSLAD----------VIIHEISHS 330

  Fly   339 WFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLY-PDYHLDE----QFVVRQMQLIFGTDAQNGTQ 398
            |||:.||.:.|..|||||.|..|.:..::..|: ..|...|    :.::||...|.|.:     .
Human   331 WFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDITGEE-----N 390

  Fly   399 PMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMG-AENFDTAIRSYLQQYHLTNTVPYNL 462
            |:.....:|:........::...|.||.|.|....:|:| .:.||:.:::|:.::...:.:..:.
Human   391 PLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDF 455

  Fly   463 FYHLFEHWP--KNQDVDLV-DFLTD-YTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNAT 523
            .....|::|  |.:.||:: .|..| :....|:|..:.....|:.:
Human   456 LDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSL------------------- 501

  Fly   524 LKYTVPITFTTNLERDFYNLTPYKYLHKTVNVLW----LDF-------TSPIDWILFNLRQSNYQ 577
                               :.|.:.|.:    ||    ||.       .||  |       ..||
Human   502 -------------------MKPAEELAQ----LWAAEELDMKAIEAVAISP--W-------KTYQ 534

  Fly   578 RVFYDDTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYV-----------------DYA 625
            .|::.|.:.:          .|.:|..|..::.|...:.:.|:..                 |:.
Human   535 LVYFLDKILQ----------KSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFW 589

  Fly   626 DVFRFLEYLAKEVEYVPWYAVYENLNTVAKRLTPE 660
            .|..||....|:...:|.|......:.||:.|..|
Human   590 KVKEFLHNQGKQKYTLPLYHAMMGGSEVAQTLAKE 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	72/285 (25%)
		M1_APN_2	34..492	CDD:189008	89/357 (25%)
		ERAP1_C	567..874	CDD:288671	20/111 (18%)
RNPEP	NP_064601.3	leuko_A4_hydro	24..634	CDD:274120	120/555 (22%)
		M1_LTA4H	24..484	CDD:189006	88/352 (25%)
		Substrate binding. /evidence=ECO:0000250	298..302		2/3 (67%)
		Leuk-A4-hydro_C	504..644	CDD:286244	29/144 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910