Protein Alignment CG42335 and RNPEPL1

DIOPT Version :10

• Sequence 1: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_060696.4
• Gene: RNPEPL1 / 57140
• HGNCID: 10079
• Length: 725
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 128/556 - (23%)
• Similarity: 202/556 - (36%)
• Gaps: 126/556 - (22%)

  Fly   146 YVERDTNVTRWL------------ALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIAN 198
            |...|.....||            ..||...:..|...||||.||:|..:...:..|:|.|.:.:
Human   169 YTSTDAPAIWWLDPELTYGCAKPFVFTQGHSVCNRSFFPCFDTPAVKCTYSAVVKAPSGVQVLMS 233

  Fly   199 TKLKETKALSQDRFVDHFKETPVMSTYLLAFMVANYSARGNESEFAVLTRPEFYD--NTEFSYHV 261
            .   ...|..::..|.||.....:..||:|.:..:...........|...|....  .::.|..|
Human   234 A---TRSAYMEEEGVFHFHMEHPVPAYLVALVAGDLKPADIGPRSRVWAEPCLLPTATSKLSGAV 295

  Fly   262 GQQVVSAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEF 326
            .|.:.:|  |....||.....|::  ...|.||...|||..|......:|          ...||
Human   296 EQWLSAA--ERLYGPYMWGRYDIV--FLPPSFPIVAMENPCLTFIISSIL----------ESDEF 346

  Fly   327 AIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLY--------PDYHLDEQFVVR 383
            .:..:.||.:|.|||::||.:.|...||:|..|.|.:..:..:.|        ..:.||.  :.|
Human   347 LVIDVIHEVAHSWFGNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDA--LHR 409

  Fly   384 QMQLIFGTDAQNGTQPMTSPESEIQ-------TPSQIAYKFSGIAYAKGACIVRMWRNLMG-AEN 440
            ||:|: |.|         ||.|::|       .||.:...|:   |.||.|.|.....|.| .:.
Human   410 QMKLL-GED---------SPVSKLQVKLEPGVNPSHLMNLFT---YEKGYCFVYYLSQLCGDPQR 461

  Fly   441 FDTAIRSYLQQYHLTNTVPYNLFYHLFEHWP--KNQDVDL---VDFLTDYTEQVGYPMIIVKALQ 500
            ||..:|:|:::|..|:.|..:|.......:|  |.|.||.   ::| ..:....|.|:......|
Human   462 FDDFLRAYVEKYKFTSVVAQDLLDSFLSFFPELKEQSVDCRAGLEF-ERWLNATGPPLAEPDLSQ 525

  Fly   501 GNKVVTVEQSRFL------LNKDDGSNATLKYTVPITFTTNLERDFYNLTPYKYLHKTVNVLWLD 559
            |:.:....::.|.      |::...|.:.:..:...||.|                    .|:||
Human   526 GSSLTRPVEALFQLWTAEPLDQAAASASAIDISKWRTFQT--------------------ALFLD 570

  Fly   560 FTSPIDWILFNLRQSNYQRVFYDDTLREGLLLAISATNHSGIPVENR------AQIIDDLFNFAQ 618
                              |:.....|.:.:::::|....|.:...|.      .||:     ...
Human   571 ------------------RLLDGSPLPQEVVMSLSKCYSSLLDSMNAEIRIRWLQIV-----VRN 612

  Fly   619 AQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTVA 654
            ..|.|...|.||||.....:..:|   :||:|.|.|
Human   613 DYYPDLHRVRRFLESQMSRMYTIP---LYEDLCTGA 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	M1_APN-Q_like	34..487	CDD:341064	95/375 (25%)
		ERAP1_C	566..878	CDD:463368	20/95 (21%)
RNPEPL1	NP_060696.4	M1_LTA4H	29..512	CDD:341062	95/375 (25%)
		Leuk-A4-hydro_C	560..673	CDD:462686	26/132 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..699