DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42335 and erap1a

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_009303348.1	Gene:	erap1a / 564068	ZFINID:	ZDB-GENE-091113-7	Length:	933	Species:	Danio rerio

Alignment Length:	951	Identity:	243/951 - (25%)
Similarity:	422/951 - (44%)	Gaps:	135/951 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLL---- 86
            ||...|.|.||:|   ::..::....|.|||.|.:.|  ..:.:.||||:..|.:::..||
Zfish    43 RLPEIVKPQHYDL---LIHPNLTSLTFTGEVQIQIEV--KQDTRAIILHSKNLQVSKALLLGSRQ 102

  Fly    87 -----DAAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASY 146
                 |...::.||.:...|..|..|          .:.| ::.:..::..::.....||:...|
Zfish   103 HHHHQDLQISEFEANEQIALFSEGFT----------FEKG-SHVVHLEFYANLSDSFHGFYKGQY 156

  Fly   147 VERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDR 211
            ......| |.||.||.:..:||...|||||||.||.|.:::.|.:.:.||:|.....|..|:...
Zfish   157 TTNSGEV-RMLASTQFEPTHARAAFPCFDEPAFKANFTIRVRRESRHISISNMPKLRTVELADGI 220

  Fly   212 FVDHFKETPVMSTYLLAFMVANYSARGNES----EFAVLTRPEFYDNTEFSYHVGQQVVSAYGEL 272
            ..|.|.....|||||:||::.::.:...:|    |.:|.|.||.....|::......::..|.|.
Zfish   221 LEDQFDTMVKMSTYLVAFIICDFHSISKKSQHGVEISVYTVPEKISQAEYALDTAVTMLDFYDEY 285

  Fly   273 FQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSH 337
            |..||....:|:   |:.|.|....||||||..|.:..|:.:|..|.. |||....::||||.:|
Zfish   286 FDIPYPLPKHDL---AAIPDFQSGAMENWGLSTYRESGLLFDPEKSSS-SDKLGITKVIAHELAH 346

  Fly   338 MWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTS 402
            .|||:.||..||:..||||.||::.||...:..:|:..:::.|:.:....: ..|:.:.:.|:::
Zfish   347 QWFGNLVTMQWWNDLWLNEGFAKFMEYVSVNITHPELQVNDYFLEKCFTAL-SVDSLSSSHPVST 410

  Fly   403 PESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHL- 466
            |   ::.|::|:..|..::|.|||||:.|.|:.:..|.|...|.:||:::...|||..:|:..|
Zfish   411 P---VENPAEISEMFDDVSYRKGACILNMLRDFLTPEVFKYGIINYLKKHSYQNTVNSHLWESLT 472

  Fly   467 -------------------FEH--------WPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKV 504
                               .:|        |.|...||:...:..:|.|.|:|:|.|: ::|.:
Zfish   473 NICTSDGLDSGRLKLDGFCSKHTAETPASKWFKEDSVDVGAIMDTWTLQEGFPLITVE-VKGQE- 535

  Fly   505 VTVEQSRFLLNKDDGSNATLKYTVPITFTTN-----------LERDFYNLTPYKYLHKTVNVLWL 558
            ||::|.|||...:..::::..:.||:|:.|:           .|||.:.| |.|
Zfish   536 VTLKQERFLKGAESSNSSSFLWQVPLTYITSGSNAVQRFLLKTERDVFYL-PEK----------- 588

  Fly   559 DFTSPIDWILFNLRQSNYQRVFYD----DTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQA 619
                 ::||.||:....|..|.|:    |.|.:.|.:     ||:.....:||.:|.|:|.....
Zfish   589 -----VEWIKFNVDLRGYYIVHYESGGWDCLIKQLRM-----NHTVFSSNDRASLIHDIFQLVSI 643

  Fly   620 QYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTVAKRLTPEQLPDFRIYLSSITAAVFEKL--GV 682
            :.|..........||:||.|.:|....:..|..:.|.:....:.:....|.|....:|:.|  ..
Zfish   644 EKVPLDKALNLSLYLSKESEIMPVTQGFSELVPLYKLMEKRDMQELENQLKSHLVKLFQPLIDRQ 708

  Fly   683 GWNAQDTPLDVANRNKLIKWLCRYQASNCRPKVNVQFVTGHE------VPSPDYRETFYCAASGA 741
            .|:...:..:...||.|:.:.|..:..:|.......|....|      :|: |.....|...:..
Zfish   709 SWSDNGSVSERMLRNYLLLFACVRRYPSCVSTATQLFHKWKESDGKMWLPT-DVSLVVYTEGART 772

  Fly   742 DYNSYTMLWGQYYLENRTSEKNMLWAAISCTRDYETHYHKM----------IISGTESVEQKKIG 796
            | :.:..|..:|......|||.|:.||:|    |....||:          .|..|:.:....|.
Zfish   773 D-DGWDFLLEKYKRSVSPSEKWMIKAALS----YSPLAHKLQWLLERSSEGEIMKTQDLPSMLIS 832

  Fly   797 IARMYEENPDLVQAIFEMITENIMELAYNFQSWSDT-AEVINDMAEYFTTREQQQLLKEFYYSNH 860
            :::    ||...:..::.:..|..:|...|...|.. :.|:..:.:.::|:|....::.|:.|..
Zfish   833 VSK----NPKGFKLAWDFLKSNWGKLVKKFDLGSSAISRVVVGVTDQYSTKEMLDEVELFFGSLA 893

  Fly   861 QFFGESEELLSKSLVTVEKNLNWAETHLEGLVKYLADRNGS 901
            |..|.....:.::|..:::|:.|.:.::. |:|...|.:.|
Zfish   894 QDQGSGLRSIQQALEKIQQNILWMDRNVP-LLKAWLDHHTS 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	121/411 (29%)
		M1_APN_2	34..492	CDD:189008	142/498 (29%)
		ERAP1_C	567..874	CDD:288671	69/329 (21%)
erap1a	XP_009303348.1	Peptidase_M1	43..430	CDD:279741	121/411 (29%)
		M1_APN_2	52..525	CDD:189008	142/497 (29%)
		ERAP1_C	592..909	CDD:288671	70/331 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12102
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020