DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42335 and trhde.2

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_690889.2	Gene:	trhde.2 / 562409	ZFINID:	ZDB-GENE-070705-89	Length:	994	Species:	Danio rerio

Alignment Length:	907	Identity:	237/907 - (26%)
Similarity:	433/907 - (47%)	Gaps:	88/907 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAG 90
            ||..::.|.||:|.:.|   .:|...|.|||:|....|.:.::  |:||:|.|::.:. |:.:..
Zfish   109 RLPATLRPRHYDLRLTV---HMENFSFSGEVNIEFECVNSTKL--IVLHSDRLELDKV-LVFSDS 167

  Fly    91 AQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYV---ERDTN 152
            .:..|:.|.|..:....|...:.|....:|.:.|.:...:|.||..::.|||.:||:   ||
Zfish   168 KKAGAMRIQRRFHYQPKQVYVIALHREMKPLRTYKINITFTAHIEHELLGFFRSSYMLNGER--- 229

  Fly   153 VTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDHFK 217
              |:||:||....:||...||||||..||.|::.:...:.|||::|..::.|.:.......:||.
Zfish   230 --RFLAVTQFSPTHARKAFPCFDEPIYKATFRVSLKHESSYQSLSNMPVEATTSDEDGWVTNHFS 292

  Fly   218 ETPVMSTYLLAFMVANYSARGNESEFAVL----TRPEFYD--NTEFSYHVGQQVVSAYGELFQSP 276
            .||.||||.||:.|.|::.:...::..||    .||:...  :.:::..:.::::..|.:.|:..
Zfish   293 RTPRMSTYYLAWAVCNFTYKEAVADNGVLIRLYARPDAIQSGSGDYALRITKRLLQFYQDYFKVK 357

  Fly   277 YAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFG 341
            |:....|:|   :.|:.|:..||||||.::.:..::.:|..|......|..: ::.||..|.|||
Zfish   358 YSLPKLDLL---AVPKHPYAAMENWGLSVFVEQKILLDPDVSSFSYQMELTM-VVVHEICHQWFG 418

  Fly   342 DSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQ-FVVRQMQLIFGTDAQNGTQPMTSPES 405
            |.||..||...||.|.||.|:||.....|:|.:::::| |:...:..:...|....:.|::   .
Zfish   419 DLVTPVWWEDVWLKEGFAHYFEYIGTDFLFPKWNMEKQRFLTDVLHEVMLLDGLASSHPIS---Q 480

  Fly   406 EIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHW 470
            ::...:.|...|..|||.|||.::||..|:||...|..|:..||..:...|....:|:..|.|..
Zfish   481 QVFEATDIDRVFDWIAYKKGAALIRMLANVMGQTLFQRALNDYLMTHMYGNAARDDLWNKLSEAM 545

  Fly   471 PK-NQDVDLVDFLTDYTEQVGYPMIIVKALQG-NKVVTVEQSRFLLNKD------DGSNATLKYT 527
            .: .:|:::...:..:|.|:|||::.:..... :..:|:.|..|:.:.|      :..|.:.::.
Zfish   546 QREGKDINITQVMDRWTLQMGYPVVTISKNDSLDNSITISQEHFVYDTDAKIQNPELFNKSFQWQ 610

  Fly   528 VPITFTTNLERDFYNLTPYKYLHKTVNVLWLDFTSPI---------DWILFNLRQSNYQRVFYDD 583
            :|:|.........          .|..::|:...|..         .|:|.|:.|:.|.||.||
Zfish   611 IPLTLAVGNASHI----------STETIIWVTNKSEAHRVGHVVGETWLLGNINQTGYFRVNYD- 664

  Fly   584 TLREGLLLAISAT-NHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVY 647
             |....||....| |.:.|.|.|||.:|||:||.|:|.|:......:.:.||::|.|::||:|..
Zfish   665 -LHNWKLLIQQLTRNPTIISVGNRAGLIDDVFNLARAGYLPQNVPLQMISYLSQETEFLPWHAAS 728

  Fly   648 ENLNTVAKRLTPEQLPDFRIYLSSITAAV---FEKLGVGWNAQDTPLDVAN--------RNKLIK 701
            ..|..:.|.|  ::..|..::...:...|   :.||  ||.|......:.:        :.::|.
Zfish   729 RALYQLDKLL--DRTLDHSLFSDYVLRQVEPKYHKL--GWPATSPDGSLMHSAYQTEELQREVIM 789

  Fly   702 WLCRYQASNC-RPKVNV--QFVTGHE--VPSPDYRETFYC-AASGADYNSYTMLWGQYYLENRTS 760
            ..|.:...:| |..|::  .:::.::  :| |:.|:..|| ..|..|.:.:..:|.:::.....|
Zfish   790 LACSFGNKHCHRQAVSLISDWISSNKNRIP-PNVRDIVYCTGVSLMDEDVWEFIWMKFHSSTAVS 853

  Fly   761 EKNMLWAAISCTRDYETHYHKMIISGTESV--EQKKIGIARMYEENPDLVQAIFEMITE--NIME 821
            ||.:|..|::|:.:.......:.:|.|..:  :|..|.:......||......:....|  :|:.
Zfish   854 EKKVLLEALTCSDNIFLLNRLLNLSLTSDLVPDQDVIDVIIHVARNPLGRHLAWRYFREKWDILN 918

  Fly   822 LAYNFQSWSDTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNW 883
            ..|. ::....:::|:.:.|:..|..:...||||..::.   |||....::::..|:.|:.|
Zfish   919 SRYG-EALFMNSKLISGVTEFLNTEAELNELKEFILTSG---GESAPAFARAVEIVQANVKW 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	120/408 (29%)
		M1_APN_2	34..492	CDD:189008	137/468 (29%)
		ERAP1_C	567..874	CDD:288671	81/328 (25%)
trhde.2	XP_690889.2	Peptidase_M1	109..500	CDD:279741	120/408 (29%)
		M1_APN_2	118..568	CDD:189008	137/467 (29%)
		ERAP1_C	649..968	CDD:288671	81/329 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.110