DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42335 and anpepa

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001038326.1	Gene:	anpepa / 558452	ZFINID:	ZDB-GENE-030131-4781	Length:	946	Species:	Danio rerio

Alignment Length:	974	Identity:	250/974 - (25%)
Similarity:	432/974 - (44%)	Gaps:	193/974 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYN------LTIGVLRNSVEPT-IFDGEVSITLRVVGTLEVQQIILHADTLDITEC 83
            ||..|::|..||      |...:..|..|.: :|.|  :.|:||..|....::.||...:::|
Zfish    63 RLPDSLIPESYNVFLQPYLYAAITNNYTEQSYLFTG--NSTVRVNCTKTSSRVFLHVHNINVT-- 123

  Fly    84 WLLDAAGAQVEAIDISR-------LIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGF 141
                  ..:|...|.:.       .|::..|..:.:.|..|.:....|.:..::.|.:..|:.||
Zfish   124 ------AVEVRKSDTNEKLPLKGYQIFKNETNFLDIHLEVAIKENGTYDIFTEFEGELLEDLTGF 182

  Fly   142 FSASYVER---DTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIV-RP------------ 190
            :::.|..:   |.:..|:||.:.:|..:||.|.|||||||:||.|.:.|: ||
Zfish   183 YASRYTGKGTDDEDEERFLATSLLQPTDARTVFPCFDEPAMKAVFTITIIHRPEIRARSNEDGDP 247

  Fly   191 -----NGYQSIANTKLKETKALSQDRFVDHFKETPVMSTYLLAFMV-----ANYSARGNESEFAV 245
                 ||...|..|                ||.|..||:|||.|::     .:|.::|..::..|
Zfish   248 RTIQINGTDWIRTT----------------FKPTKKMSSYLLGFIIYDTHTFSYVSKGTRTKIHV 296

  Fly   246 LTRPEFYD--NTEFSYHVGQQVVSAYGELF--QSPYAELGNDVLQYASSPRFPHNGMENWGLIIY 306
            ..|.|..|  :.:::....:.::|.|..:|  :.|.:::....|     |.|....|||||.|.|
Zfish   297 HGRSEAIDAGHADYALETTETILSHYENIFGLRYPMSKIDQIAL-----PDFGVRAMENWGFISY 356

  Fly   307 SDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLY 371
            .:..|:.:...:..: |:|....:||||.:|.|||:.||.|||:..||.|.||.|..|.....:
Zfish   357 QESGLLYDKETASTF-DEEQVTTLIAHELAHQWFGNLVTMSWWNDLWLKEGFATYMSYKGVEAV- 419

  Fly   372 PDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLM 436
             .:.|.:..|:|::|..|..|:.|.:.|::....::||.|||:..|..|.|:|||.::||....|
Zfish   420 -GWDLKDLIVLREIQTAFQMDSLNTSHPLSMNAYDVQTSSQISELFDDITYSKGAAVLRMLATRM 483

  Fly   437 GAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHWPKNQD--VDLVDFLTDYTEQVGYPMIIVKAL 499
            |...|...::.||.::...||||.:|:..|      |.|  :.:.:|:..:||:||||::.:...
Zfish   484 GENEFMKGVKMYLSKFQFENTVPKDLWECL------NMDTHIKVDEFMKTWTEEVGYPVLTIITD 542

  Fly   500 QGNKVVTVEQSRFLLNKDDGSNATLKYTVPITFTTNLE---RDFYNLTPYKYLHKTVNVLWLDFT 561
            .|:    ..|.:|||.|:.|.::.  :.:||.:.| |:   ::|.|.                ||
Zfish   543 TGD----TSQEQFLLKKEGGHDSL--WHIPIKYMT-LKAGVKEFPNF----------------FT 584

  Fly   562 ----SPI--------DWILFNLRQSNYQRVFYDDTLREGLLLAISATNHSGIPVENRAQIIDDLF 614
                .||        :|:|.|:..:.:.||.||:. ....|.|....||..||:.||.|:|||.|
Zfish   585 DKGPDPIPDFKIGKDNWLLANINCTGFYRVNYDEE-NWNRLTAQLQKNHRIIPLINRGQLIDDAF 648

  Fly   615 NFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTVAKRLTPEQL--PDFRIYLSSITAAVF 677
            |.|:|..::........:||..::||:||.:..:||:.........::  |..: ||.::...::
Zfish   649 NLARAHRLNVTIALNLTKYLINDLEYIPWESALKNLDFFTLMFDRSEVYGPIMK-YLRNLVTPLY 712

  Fly   678 EKLGVGWNAQDTPL----DVANRNKLIKWLCRYQASNCRPK-------VNVQFVTGHEVPSPDYR 731
            |:..........|:    |..|:...|...|    ||..|:       :...:..|.....|:.|
Zfish   713 EEYEEYTINGTIPIEKYTDQCNQVNAITVAC----SNGLPECITMAKDLFSDYKNGSNPIHPNLR 773

  Fly   732 ETFYCAA-SGADYNSYTMLWGQYYLENRTSEKNMLWAAISCTRD------YETHYHKMIISGTES 789
            ...||:| :..|.:.:..:|.:|......:||:.|..|:|||::      |..:          :
Zfish   774 RAVYCSAVASGDEDDWEYVWEEYQKATVAAEKDKLRYALSCTKEIWLLNRYLQY----------T 828

  Fly   790 VEQKKIGIARMYEENPDLVQAIFEMITENI--MELAYNF--QSWS-----------DTAEVINDM 839
            :|..||       ...|:|..| ..|.:|:  ..||::|  ..||           ....:::.:
Zfish   829 LEPSKI-------RKMDMVSTI-SYIAQNVAGQPLAWDFIRGHWSYITQEYGAGIISLGSLLDVV 885

  Fly   840 AEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTV----EKNLNWAETHLEGLVK--YLAD 897
            .:.|:|..:.:.||:......|   :.:.:.:::|..|    ..|:.|.:.:.: :||  ::|:
Zfish   886 TKRFSTEVELEELKQLQREQIQ---DDKWIAARALEQVIERTAANIIWVKENKQ-VVKDWFIAE 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	123/442 (28%)
		M1_APN_2	34..492	CDD:189008	142/503 (28%)
		ERAP1_C	567..874	CDD:288671	77/341 (23%)
anpepa	NP_001038326.1	Peptidase_M1	63..472	CDD:279741	123/442 (28%)
		M1_APN_2	71..535	CDD:189008	142/503 (28%)
		ERAP1_C	602..923	CDD:288671	79/347 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.110