DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and SP1029

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster

Alignment Length:	938	Identity:	256/938 - (27%)
Similarity:	428/938 - (45%)	Gaps:	128/938 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLE-VQQIILHADTLDITECWL-LD 87
            |||..|:.|..|:|.|..|..:.|...|.|.|.|   ::..|| .:.:.||:..|.|.|..: |.
  Fly    32 YRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKI---LIEALENTKNVTLHSKNLTIDESQITLR 93

  Fly    88 AAGAQVE--------AIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSA 144
            ..|.:.:        |::.|...|...|.|..:       .|..|.|...:...:...:.|::.:
  Fly    94 QIGGEGKKENCVSSTAVNPSHDFYILNTCQELL-------AGNTYELYMPFAADLNRQLEGYYRS 151

  Fly   145 SYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQ 209
            ||.:...|:|:|:::||.:..:|||..||||||..||.|.:.:.....|.:|:|...||||  ..
  Fly   152 SYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPEKETK--PH 214

  Fly   210 DRFVDH----FKETPVMSTYLLAFMVANYSAR----GNESEFAVLTRPEFYDNTEFSYHVGQQVV 266
            :...|:    |:|:..|||||:|:.|.::|.:    .|.:.|....||...|..:::...|.:|:
  Fly   215 ETLADYIWCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVL 279

  Fly   267 SAYGELF--QSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIR 329
            ..|.:.|  :.|..:     :...:.|.|....||||||:.|.:..|:....:| ..:||:....
  Fly   280 QYYEQFFGIKFPLPK-----IDQIAVPDFSAGAMENWGLVTYREIALLYSAAHS-SLADKQRVAS 338

  Fly   330 IIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQ 394
            ::|||.:|.|||:.||..||:..||||.||.|........:.|::...||..:..:..||..||.
  Fly   339 VVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLSNLLTIFRRDAL 403

  Fly   395 NGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVP 459
            ..:.|::.|   ||..|:|:..|..|:|.||:.::||....:|.|:|.:.:::|||::...|...
  Fly   404 ESSHPISRP---IQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQ 465

  Fly   460 YNLF------YHLFEHWPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDD 518
            .||:      .|.:...||:.|:..:  :..:|.|.|||:|.|......:...:.|.|:|||
  Fly   466 DNLWESLTQAAHKYRSLPKSYDIKSI--MDSWTLQTGYPVINVTRDYAARTAKLNQERYLLN--- 525

  Fly   519 GSNATLKYT-----VPITFTTNLERDFYNLTPYKY---------LHKTVNVLWLDFTSPIDWILF 569
             :.....|.     ||:::||...:||.|..|..:         |.||:.    |...|..|::|
  Fly   526 -TQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQ----DLPGPDQWVIF 585

  Fly   570 NLRQSNYQRVFYDDTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYL 634
            |.:.|...:|.||....:.|:..::..:...|.|.||||:|||....|.....||....|.:|||
  Fly   586 NTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYL 650

  Fly   635 AKEVEYVPWYAVYENLNTVAKRLTPEQLPDFRI---YLSSITAAVFEKLGVGWN-------AQDT 689
            .:|.||:||.:.:|||..|.:.:  .|.|||..   |:..:...::|.|. |.|       .||
  Fly   651 QREREYLPWKSAFENLKRVGRIV--RQTPDFEFFKRYMKKLILPIYEHLN-GINDTFSAIPQQD- 711

  Fly   690 PLDVANRNKLIKWLCRYQASNCRPKVNVQFVTGHEVPSPD--------YRETFYCAA--SGADYN 744
              .|..:..::.|.|:||..:|.|:....:.......:||        .|.|.||.:  .|:| :
  Fly   712 --QVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSD-S 773

  Fly   745 SYTMLWGQYYLENRTSEKNMLWAAISCTRD--YETHYHKMIISGTESVEQK------------KI 795
            .:..||.:|...|..:||..:..|:.|:|:  ....|.::.....|::.::            ::
  Fly   774 DWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEV 838

  Fly   796 G--IARMY-EENPDLVQAIFEMITENIMELAYNFQSWSDTAEVINDMAEYFTTREQQQLLKEFYY 857
            |  :|:.| .:|.|.:...:..:|:             |.:.:::.::|...|.......|:|..
  Fly   839 GFLLAKKYFMDNVDFIYKFYHPLTK-------------DMSRLLSPLSEQVITLSDFNEFKDFVN 890

  Fly   858 SNHQFFGESEELLSKSLVTVEKNLNWAE 885
            ::.|.....|:.:.::|..:..|:.|.|
  Fly   891 NSRQSLKGLEQAIQQTLEIMLTNVQWKE 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	125/418 (30%)
		M1_APN_2	34..492	CDD:189008	141/483 (29%)
		ERAP1_C	567..874	CDD:288671	82/343 (24%)
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	125/418 (30%)
		M1_APN_2	43..502	CDD:189008	141/481 (29%)
		ERAP1_C	583..908	CDD:288671	82/344 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020