Protein Alignment CG42335 and ERAP1

DIOPT Version :10

• Sequence 1: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_005272072.1
• Gene: ERAP1 / 51752
• HGNCID: 18173
• Length: 951
• Species: Homo sapiens
• Alignment Length: 969
• Identity: 234/969 - (24%)
• Similarity: 426/969 - (43%)
• Gaps: 133/969 - (13%)

  Fly    10 WLLCSLLICV----------TNAADYRLEGS------------VVPSHYNLTIGVLRNSVEPTIF 52
            :||.|||..:          |.|:..|.:|:            |:|.||:|   ::..::....|
Human    15 FLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDL---LIHANLTTLTF 76

  Fly    53 DGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAGAQVEAIDISRLIYEAATQQVRVPLTEA 117
            .|...:  .:..:.....||||:..|.|:...|...||.::....: :::.....:|:.:...|.
Human    77 WGTTKV--EITASQPTSTIILHSHHLQISRATLRKGAGERLSEEPL-QVLEHPRQEQIALLAPEP 138

  Fly   118 AQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQ 182
            ...|..||:...|.|::.....||:.::|..::..: |.||.||.:...||:..|||||||.||.
Human   139 LLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGEL-RILASTQFEPTAARMAFPCFDEPAFKAS 202

  Fly   183 FQLQIVRPNGYQSIANTKLKETKALSQDRFVDHFKETPVMSTYLLAFMVANYSARGNES----EF 243
            |.::|.|...:.:|:|..|.::..:::....|||..|..|||||:||:::::.:....:    :.
Human   203 FSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKV 267

  Fly   244 AVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSD 308
            :|...|:..:..:::......::..|.:.|..||.....|:   |:.|.|....||||||..|.:
Human   268 SVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDL---AAIPDFQSGAMENWGLTTYRE 329

  Fly   309 DVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPD 373
            ..|:.:...|.. |.|......:|||.:|.|||:.||..||:..||||.||::.|:......:|:
Human   330 SALLFDAEKSSA-SSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPE 393

  Fly   374 YHLDEQFVVRQMQLIFG-------TDAQNGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRM 431
            ..:.:.|        ||       .||.|.:.|:::|   ::.|:||...|..::|.|||||:.|
Human   394 LKVGDYF--------FGKCFDAMEVDALNSSHPVSTP---VENPAQIREMFDDVSYDKGACILNM 447

  Fly   432 WRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHL------------------------FEHWPK 472
            .|..:.|:.|.:.|..|||::...||...:|:..:                        ..|| .
Human   448 LREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHW-H 511

  Fly   473 NQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNATLKYTVPITFTTNLE 537
            .:.||:...:..:|.|.|:|:|.:.....|  |.::|..::...|...:....:.||:||.|: :
Human   512 QEGVDVKTMMNTWTLQKGFPLITITVRGRN--VHMKQEHYMKGSDGAPDTGYLWHVPLTFITS-K 573

  Fly   538 RDFYNLTPYKYLHKT-VNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTLREGLLLAISATNHSGI 601
            .|..    :::|.|| .:||.|  ...::||.||:..:.|..|.|:|...:.|...:..| |:.:
Human   574 SDMV----HRFLLKTKTDVLIL--PEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGT-HTAV 631

  Fly   602 PVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLN-------TVAKRLTP 659
            ...:||.:|::.|.......:..........||..|.|.:|   |::.||       .:.||...
Human   632 SSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMP---VFQGLNELIPMYKLMEKRDMN 693

  Fly   660 EQLPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVANRNKLIKWLCRYQASNCRPKVNVQFVTGH- 723
            |....|:.:|..:...:.:|  ..|..:.:..:...|::|:...|.:....|     ||...|:
Human   694 EVETQFKAFLIRLLRDLIDK--QTWTDEGSVSERMLRSQLLLLACVHNYQPC-----VQRAEGYF 751

  Fly   724 ----------EVPSPDYRETFYCAASGADYNSYTMLWGQYYLENRTSEKNMLWAAISCTRDYETH 778
                      .:|.......|...|...:  .:..|:.:|.....::||:.:..|:..|::.|
Human   752 RKWKESNGNLSLPVDVTLAVFAVGAQSTE--GWDFLYSKYQFSLSSTEKSQIEFALCRTQNKE-- 812

  Fly   779 YHKMIISGTESVEQKKI------GIARMYEENPDLVQAIFEMITENIMELAYNFQSWSDT-AEVI 836
              |:.....||.:..||      .|..:...||......::.:.:|..:|...|:..|.: |.::
Human   813 --KLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMV 875

  Fly   837 NDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNWAETHLEGLVKYL 895
            ......|:||.:.:.:|.| :|:.:..|.....:.:::.|:|:|:.|.:.:.:.:..:|
Human   876 MGTTNQFSTRTRLEEVKGF-FSSLKENGSQLRCVQQTIETIEENIGWMDKNFDKIRVWL 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	M1_APN-Q_like	34..487	CDD:341064	130/487 (27%)
		ERAP1_C	566..878	CDD:463368	68/336 (20%)
ERAP1	XP_005272072.1	M1_APN-Q_like	61..526	CDD:341064	130/487 (27%)
		ERAP1_C	597..916	CDD:463368	68/336 (20%)