DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and CG46339

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster

Alignment Length:	927	Identity:	234/927 - (25%)
Similarity:	400/927 - (43%)	Gaps:	103/927 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PSHYNLTIGVLRNSVEPTIFDGEVSITLR--VVGTLEVQQIILHADTLDITEC----WLLDAAGA 91
            |.||:|   ::..||..:|.:|.::|.:.  |......:.|:|....:.|:..    .|.|.|..
  Fly   296 PLHYSL---LIEPSVATSISNGSLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRALADGASN 357

  Fly    92 QVEAIDI---SRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNV 153
            ..|..|:   |....:.||..:.:..|.|.:......|...:...:...:.|.:..||...||..
  Fly   358 ASEEQDLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKN 422

  Fly   154 TRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQ-SIANTKLKETKALSQDRFVDHFK 217
            ..|:..||...::||...||||.|.:||.|.:.||||..:: :::|.....::...:....|.|:
  Fly   423 EEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRDDFE 487

  Fly   218 ETPVMSTYLLAFMVANY-------SARGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELF-- 273
            .||.|.|||:||:|:|.       ...|......:.|||:|...|.::|.:.::.:..|.:.|
  Fly   488 TTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRKFLPYYEDFFGI 552

  Fly   274 --QSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLI--QEPGYSDDWSDKEFAIRIIAHE 334
              :.|..:|       .|.|.|....|||||||.:.|..|:  ::...:......:....|||||
  Fly   553 KNKLPKIDL-------VSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHE 610

  Fly   335 TSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQP 399
            .:|.|||:.||..||...||.|.||.|..|......:|::...:...:.:.:.....||.|.:..
  Fly   611 LAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHA 675

  Fly   400 MTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFY 464
            ::   .::::.:.:...|..|:|:||..::||..:::|...|.:|.|..|:::...|....:|:.
  Fly   676 IS---FDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWA 737

  Fly   465 HLFEH------WPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLL-NKDDGSNA 522
            .|..|      .||  |:.:...:..:..|.|||::.|:. :|..:| :.|.|:|| :|:....:
  Fly   738 MLTRHGHEQGTLPK--DLSVKQIMDSWITQPGYPVVNVER-RGADLV-LRQERYLLPSKNTADQS 798

  Fly   523 TLKYTVPITFTTNLERDFYNLTPYKYLHK------TVNVLWLDFTSPIDWILFNLRQSNYQRVFY 581
            |  :.:||||.|:..|...|: |..::..      .|..::...::..:.|..||.:..|.||.|
  Fly   799 T--WFIPITFETDELRKGDNI-PTHWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNY 860

  Fly   582 DDTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEV-EYVPWYA 645
            |.|    ..||:. .|.|.:|...|||::||..:.:||:|:.|.....||..|...| :.:.|.|
  Fly   861 DMT----SWLALK-KNFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLWIA 920

  Fly   646 VYENLNTVAKRLTPEQLPD-FRIYLSSITAAVFEKLGVGWNAQDTPLDVANRNKLIKWLCRYQAS 709
            ....||.:...|..|...: ||.::..|....|:..|:.....::.|.:.:|..:..:.|::...
  Fly   921 AKPGLNYLIYNLKREPAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLKHRALVAYFACKFNYD 985

  Fly   710 NCRPKVNVQFVTGHEVP-----SPDYRETFYCA--ASGADYNSYTMLWGQYYLENRTSEKNMLWA 767
            .|..|..::|......|     .|:.:...||.  |.|:....| ..:.||......|||..:..
  Fly   986 RCTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWY-FAYKQYKTTTSASEKEEILT 1049

  Fly   768 AISCTRD--YETHYHKMIISGTESVEQKKIGIA-RMYEENPDLVQAIFEMITENIMELA-YNFQS 828
            ::.||..  ..:.|..|.|:.|..:.::...:| |....|....:..|:.:..||.|:. |....
  Fly  1050 SLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDG 1114

  Fly   829 WSDTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGES-----------EELLSKSLVTVEKNLN 882
            :|..:|:|..:..|..        |:  |..||....:           |..:..:|..|..|:.
  Fly  1115 FSTLSEMIKSLTIYMN--------KD--YHKHQLLDLAATCRKLGLHAVESAIELALEQVNNNIY 1169

  Fly   883 W-------AETHLEGLV 892
            |       .:..|||:|
  Fly  1170 WRSHSYHSLKNFLEGIV 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	109/414 (26%)
		M1_APN_2	34..492	CDD:189008	126/486 (26%)
		ERAP1_C	567..874	CDD:288671	79/330 (24%)
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	109/414 (26%)
		M1_APN_2	297..769	CDD:189008	126/486 (26%)
		ERAP1_C	846..1138	CDD:288671	77/307 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020