DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and CG11951

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	934	Identity:	249/934 - (26%)
Similarity:	437/934 - (46%)	Gaps:	99/934 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHAD--TLDITECWLLD 87
            :||..::.|..|::.|.....:.:...|:|.|.|.:.|:  .....|.||:.  |:|.||..|..
  Fly    25 FRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVL--QNTHNITLHSKDLTIDDTEITLSQ 87

  Fly    88 AAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTN 152
            ..|.:.....|:............:...:....|:.|.|...::..::..:||::.:|||....|
  Fly    88 IGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVAN 152

  Fly   153 VTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDH-- 215
            .|||:::||.:...|||..||||||..||.|.:.:.....|..::|..:.||:  ..:...|:
  Fly   153 ETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETR--PHESIPDYVW 215

  Fly   216 --FKETPVMSTYLLAFMVANYSAR----GNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELF- 273
              |:|:..|||||:|:.:.::|.:    .|.:.|....||...|..:::..:|.:|:..|.|||
  Fly   216 TSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYEELFG 280

  Fly   274 -QSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSH 337
             :.|..:     :...:.|.|....||||||:.:::..|:..|.||...:.:|.| .|:|||.:|
  Fly   281 IKFPLPK-----VDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETA-NIVAHELAH 339

  Fly   338 MWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTS 402
            .|||:.||..||:..||||.||.|........::|.:...:...:..:..||..|:...:.|::.
  Fly   340 QWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLESSHPISR 404

  Fly   403 PESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLF 467
            |   |:..|||:..|..|:|.||:.::||....:|.|.|.|.::|||::|...|....||:..|.
  Fly   405 P---IEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLT 466

  Fly   468 EHWPKN----QDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNATLKYTV 528
            :...|.    :|.::...:..:|.|.|||:|.|.....::...:.|.|:|||.|........:.|
  Fly   467 QAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGCWWV 531

  Fly   529 PITFTTNLERDFYNLTPYKYLH---------KTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDT 584
            |:::|...|:||.|..|.:::.         ||::    |...|..|::||.:.|...:|.||..
  Fly   532 PLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIH----DLPGPDQWVIFNNQLSAPYKVNYDAQ 592

  Fly   585 LREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYEN 649
            ..:.|:..:::.::..|.|.||||:|||:..||.....||....:.:.||.:|.|.:||.:.::|
  Fly   593 NWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAFDN 657

  Fly   650 LNTVAKRLTPEQLPDFRIYLS---SITAAVFEKLGVGWNAQDTPLDVANRNKLI------KWLCR 705
            |..|:..|  .|.|:||.:.:   .:...::|.|. |.|  ||......::|.|      .|.|.
  Fly   658 LQFVSGIL--RQTPNFRFFKNFTRRLITPIYEHLN-GIN--DTVASEEQQDKTILKAIVADWACS 717

  Fly   706 YQASNCRPKVNVQFVTGHEVPSPD--------YRETFYCAA--SGADYNSYTMLWGQYYLENRTS 760
            ::.|:|..:....:.:.....:||        .|...||.|  .|.| ..:..||.:|...|..:
  Fly   718 FEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCD-EDWDFLWTRYQKANVAT 781

  Fly   761 EKNMLWAAISCTRD-------YETHYHKM-------IISGTESVEQKKIG--IARMY-EENPDLV 808
            ||.::..::.|:::       .|.::..|       ..|..:::...::|  :|:.| .:|.|.:
  Fly   782 EKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSI 846

  Fly   809 QAIFEMITENIMELAYNFQSWSDTAEVINDMAE-YFTTREQQQLLKEFYYSNHQFFGESEELLSK 872
            ...:...:|::.||             :..::| .||.|:..:.: .|..|:.....:.|:.:|:
  Fly   847 SKFYHPQSESMSEL-------------LPPLSEQIFTQRDYDEFM-NFMASSKDQLKDIEQTISQ 897

  Fly   873 SLVTVEKNLNWAETHLEGLVKYLA 896
            ||.|:..|:.|.|.:.|...:.::
  Fly   898 SLETMLINVQWKERNYERFTRAIS 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	118/410 (29%)
		M1_APN_2	34..492	CDD:189008	136/473 (29%)
		ERAP1_C	567..874	CDD:288671	80/343 (23%)
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	133/467 (28%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	83/347 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020