DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and CG8773

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_650273.2	Gene:	CG8773 / 41634	FlyBaseID:	FBgn0038135	Length:	994	Species:	Drosophila melanogaster

Alignment Length:	925	Identity:	241/925 - (26%)
Similarity:	421/925 - (45%)	Gaps:	108/925 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDA 88
            ||||.|::.|:||:|   .|..::|...|.|:.:||:.|....:  ||:||:..|:|:...:::.
  Fly   120 DYRLPGTLKPTHYDL---YLFPNIETGEFSGQETITITVEEATD--QIVLHSLNLNISSVSIMNT 179

  Fly    89 AGAQVEAIDIS-RLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTN 152
            ....:|.::.: ..:.|....|:..|||:    |:...|...:.|.:...:.|.:|:|||:.| .
  Fly   180 GSDTLEILETTVDAVREFLIFQLNEPLTK----GRTVRLHIGFEGSMANKIVGLYSSSYVKED-E 239

  Fly   153 VTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNG--YQSIANTKLKETKALSQDRF--V 213
            ..:|:|.::.:...||...||||||||||:|.:.:|.|:|  |.:::|  :....::||..|  |
  Fly   240 TRKWIATSKFEPTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSN--MNVDSSVSQGAFQEV 302

  Fly   214 DHFKETPVMSTYLLAFMVANYSAR---------GNESEFAVLTRPEFYDNTEFSYHVGQQVVSAY 269
            ...|..| |||||..|:|::::.:         |.....:|...||..|..:.:..:|:.|:..|
  Fly   303 TFAKSVP-MSTYLACFIVSDFAYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYY 366

  Fly   270 GELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHE 334
            .:.||..|.   ...|..|:.|.|....||:|||:.|.:..|:.:...|.. ::|:....:||||
  Fly   367 IDYFQIAYP---LPKLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSA-TNKQRIASVIAHE 427

  Fly   335 TSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQP 399
            .:|||||:.||.:||:..||||.||.:.||.....:||::.:.:||.|..:..:...|...|:.|
  Fly   428 FAHMWFGNLVTMNWWNDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHP 492

  Fly   400 MTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFY 464
            :.   ..::.|.||...|..|.|:||:.:|||..:.:|...|..|:.:||.:|..:.....|.|
  Fly   493 II---QTVENPDQITEIFDTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFF- 553

  Fly   465 HLFEHWPKNQDVD-------LVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDD---- 518
                     .::|       :.:.:..:|.|:|.|::.::.:...: ..:.|.|||.|.:|
  Fly   554 ---------TEIDKLELGYNVTEIMLTWTVQMGLPVVTIEKVSDTE-YKLTQKRFLSNPNDYDAD 608

  Fly   519 --GSNATLKYTVPITFTTNLERDFYNLTPYKYLHKTVNVLW-------LDFTSP--IDWILFNLR 572
              .|....::::|||:.|:.:             ..|..||       :..|.|  ::||.||..
  Fly   609 HEPSEFNYRWSIPITYFTSSD-------------SVVQRLWFYHDQSEITVTVPAAVEWIKFNAD 660

  Fly   573 QSNYQRVFYDDTLREGLL--LAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLA 635
            |..|.||.||..|...|.  |.:..:....:   :||.:::|.|..|.:..:.||..|....||.
  Fly   661 QVGYYRVNYDTDLWNDLADQLVVQPSAFGSV---DRAHLLNDAFALADSTQLPYATAFELTRYLD 722

  Fly   636 KEVEYVPWYAVYENLNTVAKRL-TPEQLPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVANRNKL 699
            ||.:||||......|.::.:.| .......::.|.:::...::..|  .|...:..||...|...
  Fly   723 KETDYVPWSVAASRLTSLKRTLYYTSTYAKYKKYATALIEPIYTAL--TWTVGEDHLDNRLRVTA 785

  Fly   700 IKWLCRYQASNCRPKVNVQF----VTGHEVPSPDYRET--FYCAASGADYNSYTMLWGQYYLENR 758
            :...|.....:|..:...||    ....:.|..|.|||  :|...|......:..:|..:..|:.
  Fly   786 LSAACSLGLESCLTEAGEQFNAWLAKPEDRPKADVRETVYYYGIQSVGSQEDWDAVWELFVNESD 850

  Fly   759 TSEKNMLWAAISC-------TRDYETHYHKMIISGTESVEQKKIGIARMYEENPDLVQAIFEMIT 816
            .|||:.|...:|.       .|..:..:::..:.|     |...........||.....:::.:.
  Fly   851 ASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVRG-----QDYFTCLTYISANPVGESLVWDYVR 910

  Fly   817 ENIMELAYNF-QSWSDTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKN 880
            ||...|...| .:......:|..:...|:|:.:.:.:::| ::.:...|.......::|.||:.|
  Fly   911 ENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQF-FAKYPEAGAGTAARVRALETVKNN 974

  Fly   881 LNWAETHLEGLVKYL 895
            :.|...:|||:..:|
  Fly   975 IVWLAENLEGVDAWL 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	127/412 (31%)
		M1_APN_2	34..492	CDD:189008	140/478 (29%)
		ERAP1_C	567..874	CDD:288671	68/323 (21%)
CG8773	NP_650273.2	Peptidase_M1	122..515	CDD:279741	127/412 (31%)
		M1_APN_2	130..579	CDD:189008	140/478 (29%)
		ERAP1_C	655..969	CDD:288671	68/324 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020