Protein Alignment CG42335 and npepps

DIOPT Version :10

• Sequence 1: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_001157499.1
• Gene: npepps / 407726
• ZFINID: ZDB-GENE-060524-3
• Length: 872
• Species: Danio rerio
• Alignment Length: 934
• Identity: 226/934 - (24%)
• Similarity: 400/934 - (42%)
• Gaps: 136/934 - (14%)

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAG 90
            ||...|.|.:|.|.   |:..:....|:|::...:.|  |....||:::...:||.....:...|
Zfish     9 RLPTDVYPVNYGLR---LKPDLVDFTFEGKLEAAVEV--TQGTNQIVMNCADIDIITASFVPDGG 68

  Fly    91 AQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVTR 155
            .::.|...:   |:...::|.:......|.|.. :|...:.|.:...|.||:.:.|  ..:...|
Zfish    69 EEINATGFN---YQNEDEKVTLCFPSTLQKGSG-SLKIDFVGELNDKMKGFYRSKY--SSSGEVR 127

  Fly   156 WLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDH--FKE 218
            :.|:||.:..:||...||:||||:||.|.:.::.|....:::|..:.:.|..::|:.:..  |..
Zfish   128 YAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSNMNVVDRKPYAEDQSLVEVKFAT 192

  Fly   219 TPVMSTYLLAFMVANYSARGNESEFAVLTRPEFY------DNTEFSYHVGQQVVSAYGELFQSPY 277
            ||:|||||:||::..|....::|...|..|  .|      :..:|:..|..:.:..|.:.|..||
Zfish   193 TPIMSTYLVAFVIGEYDFVESQSSDGVTVR--VYTPVGKAEQGKFALEVATKTLPFYKDYFSVPY 255

  Fly   278 AELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGD 342
            .....|::..|.   |....||||||:.|.:..|:.:|..|.. |.:::...::.||.:|.|||:
Zfish   256 PLPKIDLIAIAD---FAAGAMENWGLVTYRETALLIDPKNSCA-SSRQWVALVVGHELAHQWFGN 316

  Fly   343 SVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESEI 407
            .||..||::.||||.||.:.||......:|:|.:..|||..........||.:.:.|:   |.::
Zfish   317 LVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRALDLDALDNSHPI---EVDV 378

  Fly   408 QTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHWPK 472
            ..||::...|..|:|:|||.::||..|.:|.|:|...:.:||.::...|....:|:..|.:...|
Zfish   379 GHPSEVDEIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYLLKFQHKNASTEDLWECLEQASGK 443

  Fly   473 NQDVDLVDFLTDYTEQVGYPMIIVKALQ--GNKVVTVEQSRFLL----NKDDGSNATLKYTVPIT 531
                .:...:..:|:|:|:|:|:|...|  .::|:.:.|.:|..    |.:|..|    :.|||:
Zfish   444 ----PIAAVMNSWTKQMGFPIIVVDQEQHGSDRVLKISQKKFCASGPRNDEDCPN----WMVPIS 500

  Fly   532 FTTNLERDFYNLTPYKYL----HKTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTLREGLLLA 592
            ..|:.:.   :.|..|.|    ..|||:   ...:|..||..|.....:.|:.|...:.|.||..
Zfish   501 ICTSEDP---SCTKTKILLDQPETTVNI---TNVAPDHWIKINPGTVGFYRIQYSSAMLESLLPG 559

  Fly   593 ISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTVAKRL 657
            |  .:.:.:||: |..:.:|||:.|:|..:...:|.:.:|....|..|..|..:..||..::..|
Zfish   560 I--RDLTLLPVD-RLGLQNDLFSLARAGMISTVEVLKVMEAFVNEPNYTVWSDLSCNLGVLSSLL 621

  Fly   658 TPEQLPDFRIYLSSITAAVFEKLG--VGWNAQ--DTPLDVANRNKLIKWLCRYQASNCRPKVNVQ 718
            :.   .||...:......:|..:|  :||:::  :..||...|..::..|.:
Zfish   622 SH---TDFHEDIQEFIRDLFTPIGMKLGWDSRTGEGHLDALLRGLVLGKLGK------------- 670

  Fly   719 FVTGHEVPSPDYRETFYCAASG-----ADYNSYTMLWGQYYLENRTSEKNMLWAAISCTRDYETH 778
              .||:....:.|..|.....|     ||..|...|             .:|....|.|.|....
Zfish   671 --AGHKATLEEARRRFREHVEGKQILSADLRSPVYL-------------TVLKHGDSTTLDTMLK 720

  Fly   779 YHKMIISGTESVEQKKIGIARMYE--ENPDLVQ-------------------------------- 809
            .||.     ..::::|..|.|:..  ..|||:|
Zfish   721 LHKQ-----ADMQEEKNRIERVLGAIPAPDLIQRVLNFALSEEVRPQDTVSVIGGVAGSSKQGRK 780

  Fly   810 AIFEMITENIMELAYNFQSWSDTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSL 874
            |.::.:.:|..||...:|.....:.:|....:.|...:....:|.|:.|:|.  ..:|..:.:..
Zfish   781 AAWKFVKDNWEELHNRYQGGFLISRLIKLTVDGFAIDKMAAEVKSFFESHHA--PAAERTVQQCC 843

  Fly   875 VTVEKNLNWAETHLEGLVKYLADR 898
            ..:..|..|.:...:.:.:||..|
Zfish   844 ENILLNAAWLKRDADDIHQYLLQR 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	M1_APN-Q_like	34..487	CDD:341064	124/460 (27%)
		ERAP1_C	566..878	CDD:463368	69/354 (19%)
npepps	NP_001157499.1	M1_APN-Q_like	17..454	CDD:341064	124/460 (27%)
		ERAP1_C	533..846	CDD:463368	69/353 (20%)