Protein Alignment CG42335 and lta4h

DIOPT Version :9

• Sequence 1: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_998451.1
• Gene: lta4h / 406575
• ZFINID: ZDB-GENE-040426-2477
• Length: 611
• Species: Danio rerio
• Alignment Length: 666
• Identity: 138/666 - (20%)
• Similarity: 241/666 - (36%)
• Gaps: 176/666 - (26%)

  Fly    35 HYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAGAQVEAIDI- 98
            |.||...|   ..:..:..|:|::|:.|:.. :...:.|.:..|.|::.    :|..|....::
Zfish    20 HLNLIYHV---DFDRHVLKGKVALTVEVLED-KFSSLTLDSKDLKISKV----SANGQAAKFELG 76

  Fly    99 SRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVT----RWLA- 158
            ::..::.:..::.:|. |.:: |:          |:..:         :|.:|:.|    :||.
Zfish    77 AKHKFKGSPLEITLPF-ELSR-GQ----------HVIVE---------IEYETSPTATALQWLTP 120

  Fly   159 -----------LTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKL--KETKALSQD 210
                       .:|.|..:.|.::||.|.|::|..:..|:..|....::.:...  :|.......
Zfish   121 KQTAGKKHPYLFSQCQATHCRTMVPCQDTPSVKHTYYAQVSVPRELVALMSALRDGQEPDPSDSS 185

  Fly   211 RFVDHFKETPVMSTYLLAFMVANYSARGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQS 275
            |.:..|::...|.:||:|.:|....:|.......|.:..|:.|...:.:...:.::.. .|....
Zfish   186 RVIYRFRQPVPMPSYLIAIVVGALESREIGPRSRVWSEKEYVDEAAYEFAETETMLKT-AESLAG 249

  Fly   276 PYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWF 340
            ||.....|||  ...|.||:.||||..|...:..||.         .|:..| .:||||.||.|.
Zfish   250 PYVWGQYDVL--VLPPSFPYGGMENPCLTFVTPTVLA---------GDRSLA-GVIAHEISHSWT 302

  Fly   341 GDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLI------------FGTDA 393
            |:.||...|.:|||||....|.|..:|..:       |...:||.:.|            ||  |
Zfish   303 GNLVTNRTWEHFWLNEGHTVYIERMIARCM-------EGEQLRQFKGIGGWKELHESVKQFG--A 358

  Fly   394 QNGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGA-ENFDTAIRSYLQQY----- 452
            .|....:.....|:.|..    .||.:.|.||..::.....|||. |.|...::||:|.:
Zfish   359 NNVLTNLVPNLHEVDTDE----AFSSVPYEKGFALLYHLEELMGGPEVFMGFVKSYIQLFAYGSV 419

  Fly   453 -----------------HLTNTVPYNLFYH---------------------LFEHWPKNQDVDLV 479
                             .:.|.|.:|.:.|                     |.:.|.|.::.||.
Zfish   420 TTEEWKNYLFTYFKDKVDILNKVDWNAWMHTPGMAPVRPQYDTTMADACTSLCQKWVKAKEADLA 484

  Fly   480 DFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNATLKYTVPITFTTNLERDFYNLT 544
            .|.....:|:..|.:|            |....||.:|         .:|::....: .:.|.|.
Zfish   485 SFTEADVKQLNSPQLI------------EFMALLLQED---------PLPLSHVKKM-GEVYKLN 527

  Fly   545 PYKYLHKTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTLREGLLLAISATNHSGIPVENRAQI 609
            ..|  :..|...||.......|                   .|.:.||:......| .::....:
Zfish   528 NIK--NAEVRFRWLRICVKAQW-------------------EEAVPLALKMATEQG-RMKFTRPL 570

  Fly   610 IDDLFNFAQAQYVDYA 625
            ..:::||  ::|.|.|
Zfish   571 FTEVYNF--SKYSDEA 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	94/420 (22%)
		M1_APN_2	34..492	CDD:189008	115/531 (22%)
		ERAP1_C	567..874	CDD:288671	9/59 (15%)
lta4h	NP_998451.1	leuko_A4_hydro	18..607	CDD:274120	138/666 (21%)
		M1_LTA4H	18..449	CDD:189006	107/483 (22%)
		Leuk-A4-hydro_C	467..606	CDD:286244	30/164 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910