DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and LTA4H

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_000886.1	Gene:	LTA4H / 4048	HGNCID:	6710	Length:	611	Species:	Homo sapiens

Alignment Length:	638	Identity:	132/638 - (20%)
Similarity:	238/638 - (37%)	Gaps:	168/638 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LRNSVEPT--IFDGEVSITLRVVGTLEVQQIILHADTLDIT-ECWLLDAAGAQVEAIDISRLIYE 104
            ||.||:.|  ...|..::|::.... .::.::|  ||.|:| |..:::  |.:|:.....|..|:
Human    24 LRCSVDFTRRTLTGTAALTVQSQED-NLRSLVL--DTKDLTIEKVVIN--GQEVKYALGERQSYK 83

  Fly   105 AATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVTRWLA----------- 158
            .:..::.:|:..:    ||..:..:.:          |..|   ..::..:||.
Human    84 GSPMEISLPIALS----KNQEIVIEIS----------FETS---PKSSALQWLTPEQTSGKEHPY 131

  Fly   159 -LTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKAL-------------SQ 209
             .:|.|.|:.|.:|||.|.|::|..:..::..|           ||..||             ..
Human   132 LFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVP-----------KELVALMSAIRDGETPDPEDP 185

  Fly   210 DRFVDHFKETPVMSTYLLAFMVANYSARGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQ 274
            .|.:..|.:...:..||:|.:|....:|.......|.:..|..:.:.:.:...:.::....:| .
Human   186 SRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDL-G 249

  Fly   275 SPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMW 339
            .||.....|:|  ...|.||:.||||..|...:..:|..:...|:          :||||.||.|
Human   250 GPYVWGQYDLL--VLPPSFPYGGMENPCLTFVTPTLLAGDKSLSN----------VIAHEISHSW 302

  Fly   340 FGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFG-TDAQNG------T 397
            .|:.||...|.:|||||....|.|..:..:|:     .|:|  |....:.| .:.||.      |
Human   303 TGNLVTNKTWDHFWLNEGHTVYLERHICGRLF-----GEKF--RHFNALGGWGELQNSVKTFGET 360

  Fly   398 QPMTSPESEI-QTPSQIAYKFSGIAYAKGACIVRMWRNLMGA-ENFDTAIRSYLQQY---HLTNT 457
            .|.|....:: .....:||  |.:.|.||..::.....|:|. |.|...:::|::::   .:|..
Human   361 HPFTKLVVDLTDIDPDVAY--SSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTD 423

  Fly   458 VPYNLFYHLFEHWPKNQDVDLVDFLTD-------YTE-----QVGYPMIIVKALQGNKVVTVEQS 510
            ...:..|..|:        |.||.|..       |:.     :..|.|.:.     |..:.:.|
Human   424 DWKDFLYSYFK--------DKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLT-----NACIALSQ- 474

  Fly   511 RFLLNKDDGSNA--------------------TL-KYTVPITFTTNLERDFYNLTP-------YK 547
            |::..|:|..|:                    || :..:|:.....:: :.||...       ::
Human   475 RWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQ-EVYNFNAINNSEIRFR 538

  Fly   548 YLHKTVNVLWLD----------------FTSPI--DWILFNLRQSNYQRVFYD 582
            :|...:...|.|                ||.|:  |...|:.......|.:.:
Human   539 WLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQE 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	95/417 (23%)
		M1_APN_2	34..492	CDD:189008	110/500 (22%)
		ERAP1_C	567..874	CDD:288671	2/16 (13%)
LTA4H	NP_000886.1	leuko_A4_hydro	6..608	CDD:274120	132/638 (21%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	135..137		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	267..272		2/4 (50%)
		Inhibitor ARM1 binding. /evidence=ECO:0000269\|PubMed:24591641	362..365		1/2 (50%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18804029	564..566		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910