Protein Alignment CG42335 and LNPEP

DIOPT Version :10

• Sequence 1: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_054208557.1
• Gene: LNPEP / 4012
• HGNCID: 6656
• Length: 1097
• Species: Homo sapiens
• Alignment Length: 908
• Identity: 237/908 - (26%)
• Similarity: 412/908 - (45%)
• Gaps: 81/908 - (8%)

  Fly    23 ADYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQ-QIILHADTLDITECWLL 86
            |..||..:|||..|.|:   |..::....|.|.|:|:   |..|:|. .||||:...:|:....:
Human   236 AQIRLPTAVVPLRYELS---LHPNLTSMTFRGSVTIS---VQALQVTWNIILHSTGHNISRVTFM 294

  Fly    87 DAAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDT 151
            .|..:|.:..:|....|..   |:.:...||...|.||||..:|:.:|.:...||:..||.: ::
Human   295 SAVSSQEKQAEILEYAYHG---QIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTD-ES 355

  Fly   152 NVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDHF 216
            |..::.|.||.:.:.||...|||||||.||.|.::|:|...|.:::|...|.:..|......|.|
Human   356 NEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEF 420

  Fly   217 KETPVMSTYLLAFMVA---NYSARGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYA 278
            .|:..|||||:||:|.   |.|...|.:..::...||......::.....:::    |.||: |.
Human   421 SESVKMSTYLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLL----EFFQN-YF 480

  Fly   279 ELGNDV--LQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFG 341
            |:...:  |...:.|.|....||||||:.:.::.|:.:...| ..:|::...:|||||.:|.|||
Human   481 EIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTS-SMADRKLVTKIIAHELAHQWFG 544

  Fly   342 DSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESE 406
            :.||..||:..||||.||.:.|||...:::.:....|.|:..:.:.: ..|:.|.:.|::   |.
Human   545 NLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTM-KKDSLNSSHPIS---SS 605

  Fly   407 IQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHWP 471
            :|:..||...|..::|.||:.::.|.:..:..:.|..|:..||..:...:....:|:....|  .
Human   606 VQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNE--V 668

  Fly   472 KNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLN---KDDGSNATLKYTVPITFT 533
            .||.:|:...:..:|.|.|:|::.|:  :..|.:.::|.||.||   :...|:.:..:.:|:::.
Human   669 TNQTLDVKRMMKTWTLQKGFPLVTVQ--KKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYV 731

  Fly   534 TNLERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTLREGLLLAISATNH 598
            |. .|::........|.|...|  ::.|..:.|:..|:..:.|..|.|.|...|.|:..:. .|.
Human   732 TE-GRNYSKYQSVSLLDKKSGV--INLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLK-INP 792

  Fly   599 SGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVP----------WYAVYENLN-- 651
            ..:..::||.:|:::|..|....|.....|..:.||..|....|          .|.:.|.|.
Human   793 YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYM 857

  Fly   652 TVAKRLTPEQLPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVANRNKLIKWLCRYQASNCRPKVN 716
            .:|.||....   |::..:.|....       |..:.||.....|:.|:::.|.:...||.....
Human   858 DLASRLVTRV---FKLLQNQIQQQT-------WTDEGTPSMRELRSALLEFACTHNLGNCSTTAM 912

  Fly   717 VQF-----VTGHEVPSPDYRETFYCAASGADYNSYTMLWGQYYLENRTSEKNMLWAAISCTRDYE 776
            ..|     ..|.:....|...|.:...:..| ..::.|.|:|......:|||.:..|::.:.|..
Human   913 KLFDDWMASNGTQSLPTDVMTTVFKVGAKTD-KGWSFLLGKYISIGSEAEKNKILEALASSEDVR 976

  Fly   777 THY--HKMIISGTESVEQKKIGIARMYEEN-PDLVQAIFEMITENIMELAYNFQSWSDTAEVIND 838
            ..|  .|..::|.....||...|.|....: |..:.| ::.:.||..:|...|...|.|.:.|..
Human   977 KLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLA-WDFVKENWNKLVQKFPLGSYTVQNIVA 1040

  Fly   839 MAEY-FTTREQQQLLKEFYYSNHQFFGESE-----ELLSKSLVTVEKNLNWAETHLEGLVKYL 895
            .:.| |:|:.....::.|      |..:||     ..:.::|..::.|:.|.|.:|:.|..:|
Human  1041 GSTYLFSTKTHLSEVQAF------FENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	M1_APN-Q_like	34..487	CDD:341064	133/458 (29%)
		ERAP1_C	566..878	CDD:463368	73/337 (22%)
LNPEP	XP_054208557.1	M1_APN-Q_like	247..684	CDD:341064	133/458 (29%)
		ERAP1_C	761..1081	CDD:463368	73/338 (22%)