DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and Psa

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster

Alignment Length:	904	Identity:	236/904 - (26%)
Similarity:	407/904 - (45%)	Gaps:	80/904 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAG 90
            ||..:|||.||.|   :|:.:::...|.|:..:.:.|  .....||.|:|  |||    :||:..
  Fly   218 RLPTNVVPRHYEL---LLQPNLKEFTFTGKTVVQVNV--KEPTTQITLNA--LDI----VLDSVE 271

  Fly    91 AQVEAIDI--SRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNV 153
            ...|...:  .:::|.|..:...:...:.........|...:||.:...|.||:.:.|. .....
  Fly   272 LHFECSKLKPEKIVYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYF-GPNGE 335

  Fly   154 TRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVD---- 214
            .|:..:||.:..:||...||:||||:||.|.:.:|.|....:::|..:     :.:|...|
  Fly   336 ERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPV-----IKEDSLPDGLRR 395

  Fly   215 -HFKETPVMSTYLLAFMVANYSARGNESEFAVLTRPEF-----YDNTEFSYHVGQQVVSAYGELF 273
             .|..||:|||||:|.:|..|.....:|:..||.| .|     .:...|:..|..:|:..|.:.|
  Fly   396 VRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVR-VFTPVGKREQGTFALEVATKVLPYYKDYF 459

  Fly   274 QSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHM 338
            ...|.....|::..:.   |....||||||:.|.:..::.:|..:.....:..|: .:.||.:|.
  Fly   460 NIAYPLPKMDLIAISD---FSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIAL-TVGHEIAHQ 520

  Fly   339 WFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSP 403
            |||:.||..||::.||||.:|.:.|:...|.|:|:|.:..|||..........|:...:.|:..|
  Fly   521 WFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVP 585

  Fly   404 ESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFE 468
               :..||:|...|..|:|.|||.::||..:.:|.:.|...:..||.::...||...:|:..|.|
  Fly   586 ---VGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQE 647

  Fly   469 HWPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNK---VVTVEQSRFLLNKDDGSNA--TLKYTV 528
            ...||    :.|.:|.:|:..|:|::.|::.|.:|   ::.::|.:|..   |||.|  ...:.|
  Fly   648 ASSKN----VSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTA---DGSQADENCLWVV 705

  Fly   529 PITFTTN-----LERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTLREG 588
            ||:.:|:     :.:.|       .|.|:...:.||.....|||..|.....|.|..|...:.|.
  Fly   706 PISVSTSKNPTGIAKTF-------LLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQ 763

  Fly   589 LLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTV 653
            |:.|:....   :|..:|..:|||:|...||.:...|||...::....|..|..|.|:..:|..:
  Fly   764 LMPAVEKME---LPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNL 825

  Fly   654 AKRLT-PEQLPDFRIYLSSITAAVFEKLGVGWNAQD--TPLDVANRNKLIKWLCRYQASNCRPKV 715
            ...:: .:.:.||..:..::...|..:|  ||..:|  ..||...|:.::..|..:::|:...:.
  Fly   826 HILISHTDLMEDFHRFGRNLYEPVAYRL--GWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEA 888

  Fly   716 NVQF---VTGHEVPSPDYRETFYCAA-SGADYNSYTMLWGQYYLENRTSEKNMLWAAISCTRDYE 776
            .::|   |.|.|:...|.|.|.|.|. ...|...:..:...|...:...|::.:..|:.|..|.:
  Fly   889 KIRFRRHVNGTELLPADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLK 953

  Fly   777 THYHKMIISGTESVE---QKKIGIARMYEENPDLVQAIFEMITENIMELAYNFQSWSDTAEVIND 838
              ..:.:|....|.|   |..:.:......||......:|...||..:|...:|.....:.:|..
  Fly   954 --LLRRVIDFAMSSEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQGGFLLSRLIKY 1016

  Fly   839 MAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNWAETHLEGLVKYLAD 897
            :.|.|.:.|:.:.::||...| |..| .|..:|:::.|:..|..|.:...|.|..:|.|
  Fly  1017 LIENFASEERAKEVEEFLQVN-QIPG-CERTVSQAVETIRLNAAWLQRDREQLAIFLRD 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	115/410 (28%)
		M1_APN_2	34..492	CDD:189008	130/469 (28%)
		ERAP1_C	567..874	CDD:288671	73/316 (23%)
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	115/410 (28%)
		M1_APN_2	227..667	CDD:189008	130/468 (28%)
		ERAP1_C	742..1052	CDD:288671	73/318 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020