DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and Trhde

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001102461.1	Gene:	Trhde / 366894	RGDID:	728895	Length:	1066	Species:	Rattus norvegicus

Alignment Length:	924	Identity:	251/924 - (27%)
Similarity:	435/924 - (47%)	Gaps:	99/924 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLD--A 88
            ||.|.:.|.||||   :|...:|...|.|||::.:.....  .:.::|||..:.:.:..:.:  |
  Rat   182 RLSGHLKPLHYNL---MLTAFMENFTFSGEVNVEIACQNA--TRYVVLHASRVAVEKVQVAEDRA 241

  Fly    89 AGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYV---ERD 150
            .|    |:.::.......||.:.|.|.......::|.|...|...|..::.|||.:|||   ||
  Rat   242 FG----AVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYVIHGER- 301

  Fly   151 TNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFV-D 214
                |:|.:||....:||...||||||..||.|::.|.....|.|::|..: ||....:|.:| |
  Rat   302 ----RFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPV-ETSVFEEDGWVTD 361

  Fly   215 HFKETPVMSTYLLAFMVANYSARGNESEFAVL----TRPEFY--DNTEFSYHVGQQVVSAYGELF 273
            ||.:||:||||.||:.:.|::.|...::..|:    .||:..  .:.:::.|:.::::..|.:.|
  Rat   362 HFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYF 426

  Fly   274 QSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSD-----DWSDKEFAIRIIAH 333
            :.||:....|:|   :.|:.|:..||||||.|:.:..::.:|..|.     |      ...:|.|
  Rat   427 KVPYSLPKLDLL---AVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLD------VTMVIVH 482

  Fly   334 ETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQ-FVVRQMQLIFGTDAQNGT 397
            |..|.||||.||..||...||.|.||.|:|:.....|||.:::::| |:...:..:...|....:
  Rat   483 EICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPSWNMEKQRFLTDVLHEVMLLDGLASS 547

  Fly   398 QPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNL 462
            .|::   .|:...:.|...|..|||.|||.::||..|.||...|...::.||..:...|....:|
  Rat   548 HPVS---QEVLRATDIDKVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDL 609

  Fly   463 FYHLFEHWPKN-QDVDLVDFLTDYTEQVGYPMI-IVKALQGNKVVTVEQSRFLLNKDDGS----- 520
            :..|.|...:| :.|::.:.:..:|.|:|||:| |:..:.....:.:.|..|:.  |.|:
  Rat   610 WNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNMTAENRILITQQHFIY--DIGAKTKAL 672

  Fly   521 ---NATLKYTVPITFT----TNLERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLRQSNYQR 578
               |::..:.:|:|..    :::..:.......|..|.  .:.:||..|   |||.|:.|:.|.|
  Rat   673 QLQNSSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHH--RITYLDKGS---WILGNINQTGYFR 732

  Fly   579 VFYDDTLRE-GLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVP 642
            |.||  ||. .||:.....||..:.|.|||.:|||.|:.|:|.|:........:.||::|.:::|
  Rat   733 VNYD--LRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLP 795

  Fly   643 WYAVYENLNTVAKRLTPEQLPDFRI---YLSSITAAVFEKLGVGWNAQDTPLDVAN--------R 696
            |:|....|..:.|.|  :::.::.|   |:....|..:.||  ||...:....|..        |
  Rat   796 WHAASRALYPLDKLL--DRMENYNIFNEYILKQVATTYSKL--GWPKNNFNGSVVQASYQHEELR 856

  Fly   697 NKLIKWLCRYQASNCRPKVNV---QFVTGHEVPSP-DYRETFYC-AASGADYNSYTMLWGQYYLE 756
            .::|...|.:...:|..:.:.   .:::.:....| :.|:..|| ..|..|.:.:..:|.:::..
  Rat   857 REVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHST 921

  Fly   757 NRTSEKNMLWAAISCTRDYETHYHKMIISGTESV--EQKKIGIARMYEENP---DLVQAIFEMIT 816
            ...|||.:|..|::|:.|.......:.:|....|  :|..|.:......||   ||....|. ..
  Rat   922 TAVSEKKILLEALTCSDDRNLLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFR-DK 985

  Fly   817 ENIMELAYNFQSWSDTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNL 881
            ..|:...|. ::....:::|:.:.|:..|..:.:.||.|..|   :.|.:....|:::.|||.|:
  Rat   986 WKILNTRYG-EALFMNSKLISGVTEFLNTEGELKELKNFMKS---YDGVASASFSRAVETVEANV 1046

  Fly   882 NWAETHLEGLVKYL 895
            .|...:.:.|.::|
  Rat  1047 RWKRLYQDELFQWL 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	126/416 (30%)
		M1_APN_2	34..492	CDD:189008	142/476 (30%)
		ERAP1_C	567..874	CDD:288671	81/328 (25%)
Trhde	NP_001102461.1	M1_APN-Q_like	190..635	CDD:341064	139/471 (30%)
Trhde	NP_001102461.1	ERAP1_C	720..1044	CDD:403137	84/334 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020