DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and CG31445

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001263064.1	Gene:	CG31445 / 326140	FlyBaseID:	FBgn0051445	Length:	927	Species:	Drosophila melanogaster

Alignment Length:	959	Identity:	245/959 - (25%)
Similarity:	422/959 - (44%)	Gaps:	128/959 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FRAFWLLCSLLICVTNAAD----YRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTL 66
            |..|.|...|.:.|.|:..    |||..::.|..|.|.|..|..|.:...|.|.|.|.::.:  .
  Fly     4 FLLFVLAIGLDLSVANSISRYNHYRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKAL--Q 66

  Fly    67 EVQQIILHADTLDITECWL----LDAAGAQVEAIDISRL-------IYEAATQQVRVPLTEAAQP 120
            ..:.|.||:..|.|.|..:    :..||.....:..:.:       |:....:.:         .
  Fly    67 NTRNITLHSKNLTIDESRITLRQISGAGNMDNCVSSTSVNPTHDYYIFHTCKELL---------A 122

  Fly   121 GKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQL 185
            |..|.|...::..:...:.|::.:||.:..||.||||:.||.:..:||...||||||..||.|.:
  Fly   123 GNVYKLFLPFSADLTPQLFGYYRSSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVV 187

  Fly   186 QIVRPNGYQSIANTKLKETKALSQDRFVDH----FKETPVMSTYLLAFMVANYSAR----GNESE 242
            .:.....:.:::|..::|.:  ..:...::    |:|:..|||||:|:.|.::|.:    .|.:.
  Fly   188 TLGYHKQFNALSNMPVREIR--PHESLANYIWCEFQESVPMSTYLVAYSVNDFSFKPSTLPNGAL 250

  Fly   243 FAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYS 307
            |....||...|..:::...|.:|:..|.|.|...|.....|.:   :.|.|....||||||:.|.
  Fly   251 FRTWARPNAIDQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQM---AVPDFSAGAMENWGLVKYR 312

  Fly   308 DDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYP 372
            :..|:..|.:| ..:||:....:||||.:|.|||:.||..||:..||||.||.|.......::||
  Fly   313 ESTLLYSPTHS-SLADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYP 376

  Fly   373 DYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMG 437
            ::|..::..:..:...|..|:...:.|::.|   ||..::|...|..|:|.||:.::||....||
  Fly   377 EWHSRDKGSLTALMTAFRLDSLVSSHPISRP---IQMVTEIEESFDAISYQKGSAVLRMMHLFMG 438

  Fly   438 AENFDTAIRSYLQQYHLTNTVPYNLF------YHLFEHWPKNQDVDLVDFLTDYTEQVGYPMIIV 496
            .|:|.|.:|.||:.|...|....||:      .|.....|.:.|::.:  :..:|.|.|:|::.:
  Fly   439 EESFRTGLREYLKLYAYKNAEQNNLWESLTTAAHQNGALPGHYDINTI--MDSWTLQTGFPVLNI 501

  Fly   497 KALQGNKVVTVEQSRFLLNKD-DGSNATLKYTVPITFTTNLERDFYNLTPYKYLHKTVNVLWLDF 560
            ..........:.|.|:|.|.. ..::....:.||:::||..|.||.|.:|         ..|::.
  Fly   502 TRDYSTGTAEITQERYLRNSQIPQADRVGCWWVPLSYTTQDENDFNNTSP---------KAWMEC 557

  Fly   561 TS--------------PIDWILFNLRQSNYQRVFYDDTLREGLLLAISATNHSGIPVENRAQIID 611
            :|              |.:|::.|::.|...:..||....:.|:..:::.:...|.|.||||:||
  Fly   558 SSTDEGVPTTIDHSAGPEEWLILNIQLSTPYKANYDARNWKLLIDTLNSKDFQSIHVINRAQLID 622

  Fly   612 DLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTVAK--RLTPEQLPDFRIYLSSITA 674
            |:..||.....||....:...||.:|.:.:||.:..:||..:.:  |.|| ....|:.|:..:..
  Fly   623 DVLYFAWTGEQDYETALQVTNYLRRERDLIPWKSALDNLKLLNRILRQTP-NFGSFKRYMQKLLT 686

  Fly   675 AVFEKLGVGWN-------AQDTPLDVANRNKLIKWLCRYQASNCRPKVNVQFVTGHEVPSPD--- 729
            .::|.|. |.|       .||   :|..:..::...|:|..|:|..:....|.......:||
  Fly   687 PIYEHLH-GMNDTFSLMTQQD---EVLLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENH 747

  Fly   730 -----YRETFYCAA-SGADYNSYTMLWGQYYLENRTSEKNMLWAAISCTRD-------YETHYH- 780
                 .|.|.||.| |......:..||.:|...|..||:..:.:.:.|:::       .|..:|
  Fly   748 PVPLNLRSTVYCTAISQGTEEDWNFLWSRYRKSNVASERQTILSTLGCSKEVWILQRYMEKSFHP 812

  Fly   781 KMIISGTES------VEQKKIG--IARMY-EENPDLVQAIFEMITENIMELAYNFQSWSDTAEVI 836
            |..|...:|      |..:::|  :|:.| .||.:|:...:...|..:..|   ....|:....|
  Fly   813 KSAIRKQDSSLCFQAVASREVGFLLAKQYFIENVELIHKYYYPQTRVMSRL---LTPLSEQVSTI 874

  Fly   837 NDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNWAE 885
            ||:.::          :.|...:..|.....:.:.:||.|:..|:.|.:
  Fly   875 NDLNKF----------RSFANDSRHFLKGIRQAMQQSLETMLTNVQWMD 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	116/417 (28%)
		M1_APN_2	34..492	CDD:189008	135/482 (28%)
		ERAP1_C	567..874	CDD:288671	77/341 (23%)
CG31445	NP_001263064.1	Peptidase_M1	28..426	CDD:279741	116/417 (28%)
		M1_APN_2	43..497	CDD:189008	132/475 (28%)
		ERAP1_C	578..904	CDD:288671	79/343 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020