DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and lnpep

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_021331684.1	Gene:	lnpep / 322814	ZFINID:	ZDB-GENE-030131-1534	Length:	1026	Species:	Danio rerio

Alignment Length:	914	Identity:	238/914 - (26%)
Similarity:	420/914 - (45%)	Gaps:	104/914 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDA 88
            |.||..||.|.|||:::....||:   .|.|.|||.:.|:.  |.:.||||:..::|.:....|.
Zfish   175 DLRLPVSVHPVHYNISLHPDLNSM---TFQGNVSIVVLVMH--ETKNIILHSSDMNIIKVTFDDK 234

  Fly    89 AGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNV 153
            .         .|.:.....||:.:...|..:.|: |.|.|.|..::.....||:::|||  ||..
Zfish   235 E---------YRFLEYKPWQQIAIKFPEDLKKGQ-YVLKFSYKANLSNSYDGFYNSSYV--DTAG 287

  Fly   154 T-RWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIAN-TKLKETKALSQDRFVDHF 216
            | |.||.||.:.:.||...|||||||.|:.|.:::.|...|.|::| .|:|.|.........|.|
Zfish   288 TKRVLAATQFEPLAARKAFPCFDEPAFKSTFVVKMTREAKYISLSNMPKIKTTDLNENGLQEDEF 352

  Fly   217 KETPVMSTYLLAFMVANYSARG---NESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYA 278
            :.:..|||||:||:||.:|:..   :::..:|...|:..|...::.....:::..|...|:..|.
Zfish   353 ESSVKMSTYLVAFIVAEFSSHSKNVSKTTVSVYAVPDKKDQVHYALETACKLLKFYNTFFEIEYP 417

  Fly   279 ELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDS 343
               ...|...:.|.|....|||||||.:.:..|:  .|......||:....:||||.:|.|||:.
Zfish   418 ---LSKLDLVAIPDFLAGAMENWGLITFRETTLL--VGNQSSRFDKQLVTSVIAHELAHQWFGNL 477

  Fly   344 VTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFV-VRQMQLIFGTDAQNGTQPMTSPESEI 407
            ||..||:..||||.||.|.:|.....::||..:|.:|: ||...|  ..||.|.:.|::   :.:
Zfish   478 VTMRWWNDLWLNEGFATYMQYMSIENVFPDLDIDIEFLNVRFKAL--AKDALNSSHPVS---TFV 537

  Fly   408 QTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHWPK 472
            .||.|:...|..::|.|||.|:.|....:....|...:..|||.|:|:||...:|:..|.:  ..
Zfish   538 STPEQVEEMFDSVSYEKGASILLMLNATLRDGEFHKGVIEYLQNYNLSNTESKDLWNSLSQ--VS 600

  Fly   473 NQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNATLKYTVPITFTTNLE 537
            .|.:::.:.:..:|...|:|::.||  :....||:.|..||||.::|::.:..:.:|:|
Zfish   601 KQSLNVSEMMNTWTVHKGFPLVTVK--RNGPQVTLSQEHFLLNAENGTDDSSLWHIPLT------ 657

  Fly   538 RDFYNLTPYKYLHKTVNVL--------------WLDFTSPIDWILFNLRQSNYQRVFYDDTLREG 588
                      |::.:.:||              .|.....:.|:.||.|...:..|.||:.....
Zfish   658 ----------YVNDSCSVLRSCKQVFHLKDKEATLQLPGQVKWLKFNFRSDGFYIVHYDEQGWSD 712

  Fly   589 LLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTV 653
            |:.|:. .:.:.:|.|::|.:|:::|..::...|.:..|...::|:..|.|..|.......|..:
Zfish   713 LISALK-VDVNVLPSEDKAALINNIFALSRLGKVSFRQVLNLMDYIRNETETAPLTEALSQLGQI 776

  Fly   654 AKRLTPEQLPDFRIYLSSITAAVFEKLG-----VGWNAQDTPLDVANRNKLIKWLCRYQASNCRP 713
            .:.|  ::..|..: .||:|..:....|     ..|..:.:...:..|:.|::..|.....||..
Zfish   777 YRLL--DKRSDLNL-ASSMTTYIESHFGSLMESQSWEVETSVSKMTLRSALLETACALNRPNCTT 838

  Fly   714 KVN---VQFVTGH---EVPSPDYRETFYCAASGADYNSYTMLWGQYYLENRTSEKNMLWAAISCT 772
            :..   .|::..:   ::|| |...|.:..|:..| ..::.|.|.|......:||..:..|::.|
Zfish   839 QARRLFDQWLASNKTLQIPS-DLMRTVFKVAAKTD-EGWSKLLGSYKHSIYDTEKRKMLEALAST 901

  Fly   773 RDYETHYHKMIISGTESVEQKKIGIARMYEENPDLVQAI----------FEMITENIMELAYNFQ 827
            :|    ..|:|....:|::..:|    ..:|.|.::..:          ::.:.||..::...|.
Zfish   902 QD----VRKIIWVLQKSLDGSEI----QNQEFPLVIHTVCRDFAGYLYAWDFMKENWEKITQKFP 958

  Fly   828 SWSDTAE-VINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNWAETHLEGL 891
            ..|...: :|......|:|:.....::.| :|:....|....::.:::.|::.|:.|.|.:|..|
Zfish   959 IGSFAIQSIITSTTSQFSTKTHLAEVQNF-FSSLGAKGSQMRIVQEAIETIKHNMRWMEKNLNTL 1022

  Fly   892 VKYL 895
            ..:|
Zfish  1023 QSWL 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	131/404 (32%)
		M1_APN_2	34..492	CDD:189008	144/463 (31%)
		ERAP1_C	567..874	CDD:288671	63/328 (19%)
lnpep	XP_021331684.1	M1_APN_2	185..620	CDD:189008	144/463 (31%)
lnpep	XP_021331684.1	ERAP1_C	690..1009	CDD:314669	65/333 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020