DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and anpepb

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001082794.1	Gene:	anpepb / 322533	ZFINID:	ZDB-GENE-030131-1253	Length:	965	Species:	Danio rerio

Alignment Length:	943	Identity:	261/943 - (27%)
Similarity:	442/943 - (46%)	Gaps:	124/943 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YRLEGSVVPSHYNLTI--GVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLD 87
            :||..::.|..|.:|:  .:.:|:....||.|:.|:..|.|...::  |::|::.|.|.:...|.
Zfish    77 WRLPQTLSPETYKVTLWPRLQKNAEGLYIFTGDSSVVFRCVENTDL--ILIHSNKLTIKDSTTLK 139

  Fly    88 AAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTN 152
            |.|.......:|..:| ..||.:.:.|......|::|.|..::.|.:..|:.||:.:.|.: :..
Zfish   140 ALGGNPAPNIVSTKMY-PKTQYMAIWLDRELTAGESYELYTEFVGELSDDLGGFYRSEYYD-ENG 202

  Fly   153 VTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRF---VD 214
            |.:.:|.||||..:||...|||||||:||.|.:.::...|..:::|..:.|...::.|..   ..
Zfish   203 VLKVVATTQMQATDARKAFPCFDEPAMKAVFNIVLLHDPGTVALSNGVVIEEIPVTVDGISLTKT 267

  Fly   215 HFKETPVMSTYLLAFMVANYS---ARGNESEFAVLTRPEFYD--NTEFSYHVGQQVVSAYGELFQ 274
            .|..|..||||||||:|:.::   .:.::.:..:..|.|..|  ..|::..|..:::..:.|.:.
Zfish   268 TFAPTEKMSTYLLAFIVSEFTYIEQKLDDLQIRIFARKEAIDANQGEYALSVTGKILRFFEEYYN 332

  Fly   275 SPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMW 339
            |.|....:|.:   :.|.|....|||||||.|.:..|:.:...|.: .:||..:.:||||.:|.|
Zfish   333 SSYPLPKSDQI---ALPDFNAGAMENWGLITYRETALLYDEEMSSN-GNKERVVTVIAHELAHQW 393

  Fly   340 FGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPE 404
            ||:.||..||:..||||.||.|.||..|.:..|.:::.:..|:..:..:|..||...:.|::|.|
Zfish   394 FGNLVTIRWWNDLWLNEGFASYVEYLGADEAEPLWNIKDLIVLNDVHRVFAIDALASSHPLSSKE 458

  Fly   405 SEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEH 469
            .::|.|.||:..|..|:|:|||.::||..|.:..:.|...:|:||:.:...|||..:|:.||
Zfish   459 EDVQRPEQISEVFDTISYSKGASVLRMLSNFLSEDVFTQGLRTYLEHFKFNNTVYTDLWDHL--- 520

  Fly   470 WPKNQDVD---------LVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLN---KDDGSNA 522
               ...||         :.|.:..:..|:|:|::.:..:.|.    :.|..|||:   |.:.|..
Zfish   521 ---QMAVDETGTELPRSVKDIMDRWVLQMGFPVVTINTVTGQ----ISQEHFLLDPETKPEPSEF 578

  Fly   523 TLKYTVPITFTTNLERDFYNLTP-YKYLHKTVNVLWLDF-TSPIDWILFNLRQSNYQRVFYDDTL 585
            ..::.||||:|.|     ..:.| |..|.|  |..:.|. |:..:|:|.|:....|.||.||:..
Zfish   579 NYEWFVPITWTKN-----EAIKPQYWLLQK--NTQFDDMKTNANEWVLANINTVGYYRVNYDEQN 636

  Fly   586 REGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENL 650
            .|.||.|:. |:...|||.||||:|||.||.|:|..:......|..|:|..|.||:||.:...||
Zfish   637 WERLLNALQ-TSRESIPVINRAQLIDDAFNLAKAGIIKTTLALRTTEFLDVETEYMPWQSALNNL 700

  Fly   651 N-----------------TVAKRLTPEQLPDFRIYLSSITAAVFEKLGVGW-NAQDTPLDVANRN 697
            :                 .:.|::||     ...|.:.:|         .| ...|...:..|:.
Zfish   701 DYFYLMFDRSEVYGHMQAYIRKQVTP-----LFEYFTELT---------DWQGVPDNHTEQYNQV 751

  Fly   698 KLIKWLCRYQASNCRPKVNVQF--VTGHEVPSP---DYRETFYC---AASGADYNSYTMLWGQYY 754
            ..::..|.....||...|...|  ...:|..:|   :.|.|.||   ||.||:  .:...|..:.
Zfish   752 NALRVACSIGLKNCTDLVTSWFGEWMNNEDVNPIHANLRSTVYCSAIAAGGAE--EWEFAWKMFE 814

  Fly   755 LENRTSEKNMLWAAISCTR---------DYETHYHKM--------IISGTESVEQKKIGIARMYE 802
            ..:..|||:.|.||::|..         :|....:|:        |:|...:|..:.:..
Zfish   815 KTSVASEKDKLRAAMACATQPWLLNRYLEYTLDANKIRKQDATSTIVSIASNVGGQSLAW----- 874

  Fly   803 ENPDLVQAIFEMITENIMELAYNFQSWSDTAEVINDMAEYFTTREQQQLLKEFYYSN-HQFFGES 866
               |.|:|.:|.|.......:::|      :.:||.:.:.|:|..:.:.|.:|...| |..||..
Zfish   875 ---DFVRANWEYIFNQYGGGSFSF------SNLINGVTKRFSTEFELKQLMQFKEDNEHIGFGSG 930

  Fly   867 EELLSKSLVTVEKNLNWAETHLEGLVKYLADRN 899
            ...:.:|:...:.|:.|.|.:...::::..|::
Zfish   931 SLAIQQSIERTKANIKWVEQNKADVLQWFKDQS 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	125/408 (31%)
		M1_APN_2	34..492	CDD:189008	143/476 (30%)
		ERAP1_C	567..874	CDD:288671	88/350 (25%)
anpepb	NP_001082794.1	Peptidase_M1	78..479	CDD:279741	125/408 (31%)
		M1_APN_2	88..549	CDD:189008	143/474 (30%)
		ERAP1_C	618..940	CDD:288671	89/352 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.110