DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and CG2111

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_572644.1	Gene:	CG2111 / 31995	FlyBaseID:	FBgn0030223	Length:	931	Species:	Drosophila melanogaster

Alignment Length:	940	Identity:	242/940 - (25%)
Similarity:	416/940 - (44%)	Gaps:	114/940 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAG 90
            ||...:||..|.:.| |.|.:.....|.|.|.|.||  .....::|:|:|..|.|.:...:..:.
  Fly    25 RLPKWLVPLSYRVDI-VTRINQPYQPFGGTVVIDLR--SERSTKRIVLNAHDLAIGKRRAVTLSD 86

  Fly    91 AQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVTR 155
            ....::.:|.:..:....::.|.|....:....|::...:|..:|.|..||:|::||:.:|.:|:
  Fly    87 KNGNSVPVSSIQMDIKLSRLTVSLKRPLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQ 151

  Fly   156 WLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKET--KALSQDRFVDHFKE 218
            |||.||.:..:||...||||:|..:..|::.:..|..|::::|..::.|  .|..:|.....|.|
  Fly   152 WLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQFVE 216

  Fly   219 TPVMSTYLLAFMVANY------SARGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPY 277
            :..|.|||:|||::.:      |:..::...:...||:....|||:..|...::|.|.:||.|.|
  Fly   217 SHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDLFNSTY 281

  Fly   278 AELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGD 342
            .:...|::   :.|.|.....|||||..::::.|:.:...| ...|::...|.:|....:.|||:
  Fly   282 RQKKIDLV---ALPDFTFKSKENWGLPAFAEESLLYDSQRS-SIDDQQGVARAVAMMVVNQWFGN 342

  Fly   343 SVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESEI 407
            .|:.:||...||...||.|...|..|.|.|::...|:..::....:...||...|..:|   :.:
  Fly   343 LVSVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTDLVT---ASV 404

  Fly   408 QTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFE---- 468
            ...|.|...::.|...|.|.:..|...:||.|.:.||:|.||..| ...|...:.|:.|.:
  Fly   405 PDESHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVY-ANRTATSSDFWDLLQLQVD 468

  Fly   469 -HWPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSN--------ATL 524
             :....:.:::...:..:..|.|||::.|.....::...|.|.||.:.....:.        ..|
  Fly   469 RNGRLGKGLNITRIMKCWLGQPGYPLVTVTRNYDHRTAIVSQQRFFITPQFRNRWARNPCWWVPL 533

  Fly   525 KYTVP-------ITFTTNLERDFYNLTPYKYLHKTVNVLWLD--FTSPIDWILFNLRQSNYQRVF 580
            .||.|       |:|:..|      ..|........|.:.|:  ...|.||||||::.:...||.
  Fly   534 SYTCPSCQHSEIISFSRWL------TCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPFRVN 592

  Fly   581 YDDTLREGLLLAISATNHSG---IPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVP 642
            ||  ||...||..:..:.:.   |...||||::||||:.|.:..::|......|.||..|.|:|.
  Fly   593 YD--LRNWQLLNKTLADPNKFRLIHRVNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHEDEFVV 655

  Fly   643 WYAV---YENLNTVAKRLTPEQLPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVANRNKLIKWLC 704
            |.|.   :|.:|.|||. .|..| .|:.|:..:....|::: :..:...:..::.:|..:|:..|
  Fly   656 WVATEISFERINNVAKS-NPNYL-IFKTYMRLLLERQFKRV-ISSDLTSSSGNMTHRPVIIRLAC 717

  Fly   705 RYQASNCRPKVNVQFVTGHEVPSPD--------YRETFYCAA--SGADYNSYTMLWGQYYLENRT 759
            .|:...|......:|:.|    :|:        .|||..|.|  .|.: ....|:...|...|..
  Fly   718 EYELPACVSLARREFMKG----TPEKGGWMTIRERETVVCTAVKFGTE-GDRDMVESMYKRSNFA 777

  Fly   760 SEKNMLWAAISCTRDYETHYHKMIISGTESVEQKKIGIARMYEENPDLVQAIFEMITENIM---- 820
            :||..|..|::|:|:... ..:::|...||...:|....|           .|:.:..|.|
  Fly   778 AEKESLLTALACSRNVFA-LQRVLIWTFESSGVRKQNARR-----------TFKAVVSNSMGYRL 830

  Fly   821 ---ELAYNFQS-----WSDTAEVINDMA---EYFTTREQQQLLKEFYYSNHQFFGE-------SE 867
               .::.|.|:     .:.|.:|:|.|.   |..:|  .::||   |:|  :||.|       ||
  Fly   831 AKKYVSVNMQNIRNYCSNSTDKVVNLMTPLIECLST--PKELL---YFS--KFFKEILRDMNGSE 888

  Fly   868 ELLSKSLVTVEKNLNWAETHLEGLVKYLAD 897
            .|:...|.....|::|..|....:::.:.|
  Fly   889 RLIKILLERGNDNIHWQRTKFRPMLQAIRD 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	110/406 (27%)
		M1_APN_2	34..492	CDD:189008	123/470 (26%)
		ERAP1_C	567..874	CDD:288671	90/344 (26%)
CG2111	NP_572644.1	Peptidase_M1	25..421	CDD:279741	110/405 (27%)
		M1_APN_2	33..493	CDD:189008	123/470 (26%)
		ERAP1_C	579..897	CDD:288671	91/346 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020