DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and CG9806

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster

Alignment Length:	953	Identity:	244/953 - (25%)
Similarity:	414/953 - (43%)	Gaps:	115/953 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WLLCSLLICVTNAADYRLEGSVVPSHYNLTIGVLRNSVEPT----IFDGEVSITLRVVGTLEVQQ 70
            |.|..|.:|:..........::.|.||||:   |...|||.    .|.|||.|.|||  ..|.:.
  Fly     6 WYLIVLHLCLPIGGTGATASNLRPLHYNLS---LLTEVEPLKLSGNFSGEVIIRLRV--WRETRT 65

  Fly    71 IILHADTLDITECWLL---DAAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTG 132
            |||..:.|.:.|..||   :..|    .:.:.::...::..|:.:........|:.|||..:::|
  Fly    66 IILSNNGLQVGENVLLVRRNTGG----RVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSG 126

  Fly   133 HIRTDMAGFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIA 197
            .: :..:|:|...|:: ..:..:|:|:||:....|..|.|||:.....|.|.|.:..|.|..:::
  Fly   127 QL-SRASGYFVGGYMD-SKHHPQWIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAVS 189

  Fly   198 NTKLKETKALSQDRFV-DHFKETPVMSTYLLAFMVANYSARGNESEF----AVLT--RPEFYDNT 255
            |.::.:|....:|.:| ..|::||.||...|||.:..::.| ..:|.    |:.|  ||:..|..
  Fly   190 NMRVLKTSDHEKDDYVWTTFQQTPAMSVQKLAFSINRFTNR-TSAEIPKGPALTTWLRPKIADQG 253

  Fly   256 EFSYHVGQQVVSAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDD 320
            :::..:..|::..:..||..||..:..|.|..   |...:...|:.||:.|.:...:.....|..
  Fly   254 DYAISITPQIIVFFISLFGKPYPAMKIDQLVL---PDTAYQSHEHLGLVSYPEAAFLYSAQRSTT 315

  Fly   321 WSDKEFAIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQM 385
            .:.::.|.. :|.|.:|.|..|....   :.:||:...:.|...|....:.|.:...|..:|||.
  Fly   316 RAKQQVASH-VAQEFAHHWLSDLENA---ALYWLHNGLSDYVSGFAVDNVEPAWRFHELSMVRQA 376

  Fly   386 QLIFGTDAQNGTQPMT----SPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIR 446
            ..:...|:::...||:    |..|:.|            |..|.|.:.||..:|:|.:.|..|:|
  Fly   377 LAVLVEDSKSSAYPMSLAYASKSSDTQ------------ANQKSALLFRMLHSLIGTQAFLNALR 429

  Fly   447 SYLQQYHLTNTVPYNLFYHLFEHWPKN-----QDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVT 506
            .|||:.|..::......:|..:....|     ||:.:...:..:|.|.|||:|.|........||
  Fly   430 LYLQRSHKGSSSNQAFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVT 494

  Fly   507 VEQSRFLLNKDDGSNATLK-YTVPITFTTNLERDFYNLTPYKYL----HKTVNVLWL-DFTSPID 565
            |.|.|||.|.........: :.||:||.|.....|.:..|.::|    .:|.:.|.| :...|..
  Fly   495 VTQERFLRNPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDK 559

  Fly   566 WILFNLRQSNYQRVFYDDTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRF 630
            |::||||.:...|:.||:...:.:..|:|.||.|.|....|||:|.|:.|.|.|..|.|.....|
  Fly   560 WVVFNLRLATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNF 624

  Fly   631 LEYLAKEVEYVPWYAVYENLNTVAKRLTPEQ-LPDFRIYLSSITAAVFEKL-----GVGWNAQDT 689
            |.:|..|.|::.|.|....|..:.:.|.... :..|:.::..:....|::|     ....||..|
  Fly   625 LGHLRNEDEFIVWQAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGSAAENANIT 689

  Fly   690 PLDVANRNKLIKWLCRYQASNCRPKVNVQF----VTGHEVPSPDYRETFYCAA----SGADYNSY 746
            .|.|.    :::..||....:|......:|    :..:.:| .|..||.||.|    :.||   :
  Fly   690 ELMVI----VLQLSCRTDLESCADFALKEFAGLTLETNRIP-VDLSETIYCTAIQFGTEAD---W 746

  Fly   747 TMLWGQYYLENRTSEKNMLWAAISCTRD-----------YETHYHK-----MIISGTESVEQKKI 795
            |:|...|...|.:.|:.:|.:|::|:|:           :...|..     :|.|   :|.|..:
  Fly   747 TLLRRLYTRSNVSEERRILLSAMACSRENWALDKLLNLAFAGRYMPKDDVLLIFS---AVAQNPL 808

  Fly   796 G--IARMYEENPDLVQAIFEMITENIMELAYNFQSWSDTAEVINDMAEYFTTREQQQLLKEFYYS 858
            |  ||:.|  ..|.::||.::...|..||          |:::..:.:..||.|:...|:.|..:
  Fly   809 GYNIAKKY--LVDNIKAIIKLYGSNTDEL----------AQLVTVLMKEVTTEEELNALRMFMRT 861

  Fly   859 NHQFFGESEELLSKSLVTVEKNLNWAETHLEGLVKYLADRNGS 901
            :.|.....|....:.|...|.|::|.......|:..:.:..||
  Fly   862 DLQNLPGFEIAFRRILELGEDNISWHNRQYHNLLAAVCNITGS 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	103/416 (25%)
		M1_APN_2	34..492	CDD:189008	122/480 (25%)
		ERAP1_C	567..874	CDD:288671	85/338 (25%)
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	85/339 (25%)
		Peptidase_M1	25..392	CDD:279741	98/385 (25%)
		GluZincin	30..480	CDD:301352	122/480 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.020