DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and CG31198

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	924	Identity:	324/924 - (35%)
Similarity:	499/924 - (54%)	Gaps:	43/924 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TNAADYRLEGSVVPSHYNLTIGVLRNSVEPT------IFDGEVSITLRVVGTLEVQQIILHAD-- 76
            |...:|||...:.|.:||:|   ||..:..|      .|||||.|  .|:.......|.||:.
  Fly    36 TELNEYRLAEHITPVNYNIT---LRPYLLETDGNKRFTFDGEVWI--EVISNQTTNDIYLHSKNL 95

  Fly    77 TLDITECW------LLDAAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIR 135
            |..:.|.|      :.:....|:.|.:.:.  |:  |..|::..:.|......|.|.|.|||.:.
  Fly    96 TYSVREYWQKPTTEVANPTVIQISATNTTN--YD--TDIVKLTASTALTANTTYILHFVYTGLME 156

  Fly   136 TDMAGFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTK 200
            .||.||:.:|||: |.|||:||..||.|..:||...|.||||..||.|.:.:.|...:.|::||:
  Fly   157 DDMHGFYRSSYVD-DNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTR 220

  Fly   201 LKETKALSQDR-FVDHFKETPVMSTYLLAFMVANYSARGNESEFAVLTRPEFYDNTEFSYHVGQQ 264
            |..:...:::. |.|.:|.||.||||||||:::.:.|| .:.:|.|..|||:|..|::.|:||.|
  Fly   221 LISSYPSTEEGIFSDVYKTTPKMSTYLLAFIISEFVAR-KDDDFGVYARPEYYAQTQYPYNVGIQ 284

  Fly   265 VVSAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSD-DVLIQEPGYSDDWSDKEFAI 328
            ::...|:.....|..:|||.:..|:.|.|....||||||:.|.: .:|:.|.  :...:.::...
  Fly   285 ILEEMGQYLDKDYYSMGNDKMDMAAIPDFSAGAMENWGLLTYRERSLLVDES--ATTLASRQSIA 347

  Fly   329 RIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDA 393
            .::|||.:||||||.||..||||.||||.||||::||....:...:.|::||||.|:|.:...|:
  Fly   348 AVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDS 412

  Fly   394 QNGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTV 458
            .|.|.|::  :....||:.::..|:.|:|.|||..:||.::.||.:.|..:::.||::|...:::
  Fly   413 TNATNPLS--DENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSL 475

  Fly   459 PYNLFYHLFEHWPKNQ-DVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNA 522
            |..|......:||.:. :....|....:|||||||:|.|..  ||..|:..|.||||.:.|||::
  Fly   476 PEYLLGAWQANWPNSSYNESSKDIFKSFTEQVGYPLINVTV--GNSQVSFTQKRFLLKESDGSDS 538

  Fly   523 TLKYTVPITFTTNLERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTLRE 587
            :|||||||::||:...:|.|.|| |::.|......:.|.|.|.||:.|::|:.|.||.|.|....
  Fly   539 SLKYTVPISYTTSETNNFLNTTP-KFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWH 602

  Fly   588 GLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNT 652
            .:..|:...|..||...|||||:|||||.|:|.||.|......:|||..|..|:||.:.:...|.
  Fly   603 AIHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNY 667

  Fly   653 VAKRLTPEQLPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVANRNKLIKWLCRYQASNCRPKVNV 717
            :..|| .....||..|:.::|...:.:||....:.||.||:..|.|::.|.|||.:|:|..:...
  Fly   668 LTIRL-GNDTADFNYYIQTLTNKAYNQLGFNEASNDTALDIYLRTKILSWACRYGSSDCISQAQG 731

  Fly   718 QFVTGHEVPSPDYRETFYCAA--SGADYNSYTMLWGQYYLENRTSEKNMLWAAISC--TRDYETH 778
            .|.:...||. :.|.|.||..  .|.: ..:..|:.::..|...:|:.:|..:..|  |:.....
  Fly   732 YFQSLATVPK-NIRATVYCVGLREGGE-AEFQALYNKFKNETVATEETLLQNSFGCVKTQSLIEK 794

  Fly   779 YHKMIISGTESVEQKKIGIARMYEENPDLVQAIFEMITENIMELAYNFQSWSDTAEVINDMAEYF 843
            ...:|||.....:.|...:|.:|.||.:.|..:|.::|:...|||.....:|..|.||:::|..|
  Fly   795 VFDLIISDEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEAMGGYSAVATVISNIAARF 859

  Fly   844 TTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNWAETHLEGLVKYLAD-RNGSSCLGAT 907
            ||.:|...|:.|..:|...||.|:..|:.:..||::||.||...|.....|||: |:||:.:.|.
  Fly   860 TTNQQLTDLENFNKANGAKFGSSQATLTAAEATVKENLEWATAKLGVFRSYLANYRSGSAMVNAF 924

  Fly   908 SLVVVLLLAVGSML 921
            |.:.:|::|:.:||
  Fly   925 SAISLLMVALVTML 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	149/414 (36%)
		M1_APN_2	34..492	CDD:189008	167/474 (35%)
		ERAP1_C	567..874	CDD:288671	99/310 (32%)
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	149/414 (36%)
		M1_APN_2	50..510	CDD:189008	167/474 (35%)
		ERAP1_C	582..898	CDD:288671	102/318 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12102
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020