DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and TRHDE

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_037513.2	Gene:	TRHDE / 29953	HGNCID:	30748	Length:	1069	Species:	Homo sapiens

Alignment Length:	922	Identity:	252/922 - (27%)
Similarity:	436/922 - (47%)	Gaps:	95/922 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLD--A 88
            ||.|.:.|.||||   :|...:|...|.|||::.:.....  .:.::|||..:.:.:..|.:  |
Human   185 RLSGHLKPLHYNL---MLTAFMENFTFSGEVNVEIACRNA--TRYVVLHASRVAVEKVQLAEDRA 244

  Fly    89 AGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYV---ERD 150
            .|    |:.::.......||.:.|.|.......:||.|...|...|..::.|||.:|||   ||
Human   245 FG----AVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYVLHGER- 304

  Fly   151 TNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFV-D 214
                |:|.:||....:||...||||||..||.|::.|.....|.|::|..: ||....:|.:| |
Human   305 ----RFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPV-ETSVFEEDGWVTD 364

  Fly   215 HFKETPVMSTYLLAFMVANYSARGNESEFAVL----TRPEFY--DNTEFSYHVGQQVVSAYGELF 273
            ||.:||:||||.||:.:.|::.|...::..|:    .||:..  .:.:::.|:.::::..|.:.|
Human   365 HFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYF 429

  Fly   274 QSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSD-----DWSDKEFAIRIIAH 333
            :.||:....|:|   :.|:.|:..||||||.|:.:..::.:|..|.     |      ...:|.|
Human   430 KVPYSLPKLDLL---AVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLD------VTMVIVH 485

  Fly   334 ETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQ-FVVRQMQLIFGTDAQNGT 397
            |..|.||||.||..||...||.|.||.|:|:.....|||.:::::| |:...:..:...|....:
Human   486 EICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASS 550

  Fly   398 QPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNL 462
            .|::   .|:...:.|...|..|||.|||.::||..|.||...|...::.||..:...|....:|
Human   551 HPVS---QEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDL 612

  Fly   463 FYHLFEHWPKN-QDVDLVDFLTDYTEQVGYPMIIV--KALQGNKVVTVEQSRFLLNKDDGSNATL 524
            :..|.|...:| :.|::.:.:..:|.|:|||:|.:  .....|::: :.|..|:.:....:.| |
Human   613 WNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRII-ITQQHFIYDISAKTKA-L 675

  Fly   525 K-------YTVPITFT----TNLERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLRQSNYQR 578
            |       :.:|:|..    :::..:.......|..|.  .:.:||..|   |:|.|:.|:.|.|
Human   676 KLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHH--RITYLDKGS---WLLGNINQTGYFR 735

  Fly   579 VFYDDTLRE-GLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVP 642
            |.||  ||. .||:.....||..:.|.|||.:|||.|:.|:|.|:........:.||::|.:::|
Human   736 VNYD--LRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLP 798

  Fly   643 WYAVYENLNTVAKRLTPEQLPDFRI---YLSSITAAVFEKLGVGWNAQDTPLDVAN------RNK 698
            |:|....|..:.|.|  :::.::.|   |:....|..:.|||...|..:..|..|:      |.:
Human   799 WHAASRALYPLDKLL--DRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRRE 861

  Fly   699 LIKWLCRYQASNCRPKVNV---QFVTGHEVPSP-DYRETFYC-AASGADYNSYTMLWGQYYLENR 758
            :|...|.:...:|..:.:.   .:::.:....| :.|:..|| ..|..|.:.:..:|.:::....
Human   862 VIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTA 926

  Fly   759 TSEKNMLWAAISCTRDYETHYHKMIISGTESV--EQKKIGIARMYEENP---DLVQAIFEMITEN 818
            .|||.:|..|::|:.|.......:.:|....|  :|..|.:......||   ||....|. ....
Human   927 VSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFR-DKWK 990

  Fly   819 IMELAYNFQSWSDTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNW 883
            |:...|. ::....:::|:.:.|:..|..:.:.||.|.   ..:.|.:....|:::.|||.|:.|
Human   991 ILNTRYG-EALFMNSKLISGVTEFLNTEGELKELKNFM---KNYDGVAAASFSRAVETVEANVRW 1051

  Fly   884 AETHLEGLVKYL 895
            ...:.:.|.::|
Human  1052 KMLYQDELFQWL 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	128/416 (31%)
		M1_APN_2	34..492	CDD:189008	144/476 (30%)
		ERAP1_C	567..874	CDD:288671	80/326 (25%)
TRHDE	NP_037513.2	M1_APN-Q_like	193..638	CDD:341064	141/471 (30%)
TRHDE	NP_037513.2	ERAP1_C	723..1047	CDD:403137	83/332 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020