DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and ape2

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_595998.1	Gene:	ape2 / 2540648	PomBaseID:	SPBC1921.05	Length:	882	Species:	Schizosaccharomyces pombe

Alignment Length:	942	Identity:	239/942 - (25%)
Similarity:	396/942 - (42%)	Gaps:	154/942 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAA-- 89
            |..:|.|.||:|:   |...:|...:.|:|.:||.|:.  :...|.||...|.|     |.||
pombe    20 LPKNVKPIHYDLS---LYPDLETFTYGGKVVVTLDVLE--DSNSITLHGINLRI-----LTAALE 74

  Fly    90 -GAQ-VEAIDIS----RLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVE 148
             |:| |.|.::|    |::.:..:   .||....|      .|...:|..|.:.|.||:.:|||:
pombe    75 WGSQTVWASEVSYGDERIVLQFPS---TVPANSVA------VLTLPFTARISSGMEGFYRSSYVD 130

  Fly   149 RDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFV 213
            .|.| |::||.|||:..:||...||:|||||||.|.:.|.....|..::|....| :.:......
pombe   131 SDGN-TKYLATTQMEPTSARRAFPCWDEPALKATFTIDITAKENYTILSNMNAVE-ETVKDGLKT 193

  Fly   214 DHFKETPVMSTYLLAFMVA-----NYSARGNES---EFAVLTRPEFYDNTEFSYHVGQQVVSAYG 270
            ..|.||..|||||||::||     .|...|...   ...|.|.|.|.:..:|:..:|.:.:..:.
pombe   194 ARFAETCRMSTYLLAWIVAELEYVEYFTPGKHCPRLPVRVYTTPGFSEQGKFAAELGAKTLDFFS 258

  Fly   271 ELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYS-DDVLIQEPGYSDDWSDKEFAIRIIAHE 334
            .:|..||.....|::   :.|.|....||||||:.|. ..:|:.|...:   :..|....::.||
pombe   259 GVFGEPYPLPKCDMV---AIPDFEAGAMENWGLVTYRLAAILVSEDSAA---TVIERVAEVVQHE 317

  Fly   335 TSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQP 399
            .:|.|||:.||..:|...||||.||.:..:|..:..||::.:.|.:|...:|.....||...:.|
pombe   318 LAHQWFGNLVTMQFWDGLWLNEGFATWMSWFSCNHFYPEWKVWESYVTDNLQSALSLDALRSSHP 382

  Fly   400 MTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFY 464
            :..|   |....:|...|..|:|:||:|::||....:|.:.|...|:.|:.::...|||..:|:.
pombe   383 IEVP---IMHDYEINQIFDAISYSKGSCVIRMVSKYVGEDTFIKGIQKYISKHRYGNTVTEDLWA 444

  Fly   465 HLFEHWPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKD-DGSNATLKYTV 528
            .|...  ..||:.  ..:.::|::.|||::.|......::: :||.|||...| .....|:.|..
pombe   445 ALSAE--SGQDIS--STMHNWTKKTGYPVLSVSETNDGELL-IEQHRFLSTGDVKPEEDTVIYWA 504

  Fly   529 PITFTT-------------------NLERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLRQS 574
            |:...|                   .::.|...|..||                     .|..||
pombe   505 PLKLKTMKDGKAVVDEKAVLSDRSKKIKVDKEALESYK---------------------LNSEQS 548

  Fly   575 NYQRVFYD-DTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEV 638
            ...||.|. |.|::...:|:...::  :.||:||.:|.|:.:.::|.|...:.....::....|.
pombe   549 GIYRVNYSADHLKKLSQIAVEKPDY--LSVEDRAGLIADVASLSRAGYGKVSSTLDLIKTWKDEP 611

  Fly   639 EYVPWYAVYENLNTVAKRLTPEQLPDFRIYLSSITAAVFEKL----------GVGWNAQDTPLDV 693
            .:|.:..:...||.:...|        |...|.|.||: :||          .:||..:
pombe   612 NFVVFAEMLARLNGIKSTL--------RFESSDIIAAM-KKLVLEVSATKAHSLGWEFK------ 661

  Fly   694 ANRNKLIKWLCRYQASNCRPKVNVQFVTGHEVPSPDYRETFYCAASG-----------ADYN--- 744
            ||.:.:|:   :::::    ..|...:.|.:....|....|...|||           |.:|
pombe   662 ANDDHIIR---QFKST----VYNYAGLFGDDKVVKDALSKFDAYASGNKSAINDNLRSAVFNIAI 719

  Fly   745 ------SYTMLWGQYYLENRTSEKNMLWAAISCTRDYETHYHKMIISGTESV--EQKKIGIARMY 801
                  |:..|...|...|....:|....|...|.| |.:..|.:....:.:  ||....|....
pombe   720 RYGGAKSWDQLLEIYTKTNDPYVRNSCLRAFGVTED-EKYIQKTLDLTLDPIVKEQDIYLILVTL 783

  Fly   802 EENPDLVQAIFEMITENIMELAYNFQ-SWSDTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGE 865
            ..:.:.|.|:::..|.|..:|..... :.:....|:..:...||.......:|||:.......
pombe   784 STHKNGVLAMWKFATSNWDKLLSRLPVAGTMRGYVVRFVTSGFTHASAIDKIKEFFADKDTKL-- 846

  Fly   866 SEELLSKSLVTVEKNLNWAETHLEGLVKYLAD 897
            .|..|.:||.|:..|.::.:..|:.:.::|.:
pombe   847 YERALQQSLDTISANSSFIDKSLDDITRWLKE 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	129/414 (31%)
		M1_APN_2	34..492	CDD:189008	144/474 (30%)
		ERAP1_C	567..874	CDD:288671	69/340 (20%)
ape2	NP_595998.1	PepN	24..871	CDD:223385	237/929 (26%)
		M1_APN_2	27..468	CDD:189008	144/474 (30%)
		ERAP1_C	541..857	CDD:288671	73/363 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	4	4.010