DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42335 and Lnpep

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_766415.1	Gene:	Lnpep / 240028	MGIID:	2387123	Length:	1025	Species:	Mus musculus

Alignment Length:	904	Identity:	230/904 - (25%)
Similarity:	408/904 - (45%)	Gaps:	73/904 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ADYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLD 87
            |..||..:::|..|.|:   |..::....|.|.|:|:|:.:  .:.:.||||:...:|:....:.
Mouse   164 AQIRLPTAIIPLCYELS---LHPNLTSMTFRGSVTISLQAL--QDTRDIILHSTGHNISRVTFMS 223

  Fly    88 AAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTN 152
            |..:|.:.::|....|.   :|:.|...|....|.||||..:|:.:|.....||:..:|.:: :|
Mouse   224 AVSSQEKQVEILEYPYH---EQIAVVAPEPLLTGHNYTLKIEYSANISNSYYGFYGITYTDK-SN 284

  Fly   153 VTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDHFK 217
            ..::.|.||.:.:.||...|||||||.||.|.::|.|...:.:::|...|.:....:....|.|.
Mouse   285 EKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKITRNEHHTALSNMPKKSSVPAEEGLIQDEFS 349

  Fly   218 ETPVMSTYLLAFMVA---NYSARGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYAE 279
            |:..|||||:||:|.   |.|...|.:..:|...||.......:.....:::..|...|:..|..
Mouse   350 ESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYAVPEKIGQVHHALDTTIKLLEFYQTYFEIQYPL 414

  Fly   280 LGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDSV 344
            ...|::   :.|.|....||||||:.:.::.|:.:...| ..:|::...:|||||.:|.|||:.|
Mouse   415 KKLDLV---AIPDFEAGAMENWGLLTFREETLLYDNATS-SVADRKLVTKIIAHELAHQWFGNLV 475

  Fly   345 TFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESEIQT 409
            |..||:..||||.||.:.|||...:::.:.:..|.|:..:.:.: ..|:.|.:.|::   |.:|:
Mouse   476 TMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTM-RKDSLNSSHPIS---SSVQS 536

  Fly   410 PSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHWPKNQ 474
            ..||...|..::|.|||.::.|.::.:..:.|..|:..||..:........:|:....|...|..
Mouse   537 SEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFRHAVILYLHNHSYAAIQSDDLWDSFNEVTDKTL 601

  Fly   475 DVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLN---KDDGSNATLKYTVPITFTTNL 536
            ||.  ..:..:|.|.|:|::.|:. :|.::: ::|.||.|.   :...|:.:..:.:||::.|
Mouse   602 DVK--KMMKTWTLQKGFPLVTVQR-KGTELL-LQQERFFLRMQPESQPSDTSHLWHIPISYVT-- 660

  Fly   537 ERDFYNLTPYK---YLHKTVNVLWLDFTSPIDWILFNLRQSNYQRVFY--DDTLREGLLLAISAT 596
              |..|.:.|:   .|.|..:|  ::.|..:.|:..|...:.|..|.|  ||..   .|:.....
Mouse   661 --DGRNYSEYRSVSLLDKKSDV--INLTEQVQWVKVNSNMTGYYIVHYAHDDWT---ALINQLKR 718

  Fly   597 NHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTVAKRLTPEQ 661
            |...:..::||.:|:::|..|....|.....|..::||..|....|........|.:...|  |:
Mouse   719 NPYVLSDKDRANLINNIFELAGLGKVPLRMAFDLIDYLKNETHTAPITEALFQTNLIYNLL--EK 781

  Fly   662 LPDFRIYLSSITAAVFEKL------GVGWNAQDTPLDVANRNKLIKWLCRYQASNCRPKVNVQF- 719
            |.  .:.|||...|...||      ...|..:.||.....|:.|:::.|.:...||.......|
Mouse   782 LG--HMDLSSRLVARVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATNLFD 844

  Fly   720 ----VTGHEVPSPDYRETFYCAASGADYNSYTMLWGQYYLENRTSEKNMLWAAISCTRDYETHY- 779
                ..|.:....|...|.:...:..: ..:..|:..|......:|||.:..|::.:.|....|
Mouse   845 SWMASNGTQSLPTDVMVTVFKVGARTE-KGWLFLFSMYSSMGSEAEKNKILEALASSEDVHKLYW 908

  Fly   780 -HKMIISGTESVEQKKIGIARMYEEN-PDLVQAIFEMITENIMELAYNFQSWSDTAE-VINDMAE 841
             .|..:.|.....||...|.|....: |..:.| ::.:.||..:|.:.|...|.|.: ::.....
Mouse   909 LMKSSLDGDIIRTQKLSLIIRTVGRHFPGHLLA-WDFVKENWNKLVHKFHLGSYTIQSIVAGSTH 972

  Fly   842 YFTTREQQQLLKEFYYSNHQFFGESEELL-----SKSLVTVEKNLNWAETHLEGLVKYL 895
            .|:|:.....::.|      |..:||..|     .::|..::.|:.|...:|:.|.::|
Mouse   973 LFSTKTHLSEVQAF------FENQSEATLKLRCVQEALEVIQLNIQWMVRNLKTLSQWL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	118/401 (29%)
		M1_APN_2	34..492	CDD:189008	131/460 (28%)
		ERAP1_C	567..874	CDD:288671	70/328 (21%)
Lnpep	NP_766415.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	118/401 (29%)
		M1_APN_2	177..617	CDD:189008	131/458 (29%)
		Substrate binding. /evidence=ECO:0000250	428..432		1/3 (33%)
		ERAP1_C	690..1005	CDD:288671	70/329 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020