DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and Trhde

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_666353.2	Gene:	Trhde / 237553	MGIID:	2384311	Length:	1066	Species:	Mus musculus

Alignment Length:	926	Identity:	254/926 - (27%)
Similarity:	439/926 - (47%)	Gaps:	103/926 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLD--A 88
            ||.|.:.|.||||   :|...:|...|.|||::.:.....  .:.::|||..:.:.:..:.:  |
Mouse   182 RLSGHLKPLHYNL---MLTAFMENFTFSGEVNVEIACRNA--TRYVVLHASRVAVEKVQVAEDRA 241

  Fly    89 AGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYV---ERD 150
            .|    |:.::.......||.:.|.|.......::|.|...|...|..::.|||.:|||   ||
Mouse   242 FG----AVPVAGFFLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYVIHGER- 301

  Fly   151 TNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFV-D 214
                |:|.:||....:||...||||||..||.|::.|.....|.|::|..: ||....:|.:| |
Mouse   302 ----RFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPV-ETSVFEEDGWVTD 361

  Fly   215 HFKETPVMSTYLLAFMVANYSARGNESEFAVL----TRPEFY--DNTEFSYHVGQQVVSAYGELF 273
            ||.:||:||||.||:.:.|::.|...::..|:    .||:..  .:.:::.|:.::::..|.:.|
Mouse   362 HFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYF 426

  Fly   274 QSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSD-----DWSDKEFAIRIIAH 333
            :.||:....|:|   :.|:.|:..||||||.|:.:..::.:|..|.     |      ...:|.|
Mouse   427 KVPYSLPKLDLL---AVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLD------VTMVIVH 482

  Fly   334 ETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQ-FVVRQMQLIFGTDAQNGT 397
            |..|.||||.||..||...||.|.||.|:|:.....|||.:::::| |:...:..:...|....:
Mouse   483 EICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPAWNMEKQRFLTDVLHEVMLLDGLASS 547

  Fly   398 QPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNL 462
            .|::   .|:...:.|...|..|||.|||.::||..|.||...|...::.||..:...|....:|
Mouse   548 HPVS---QEVLRATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDL 609

  Fly   463 FYHLFEHWPKN-QDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNK-----DDGS- 520
            :..|.|...:| :.|::.:.:..:|.|:|||:|   .:.||   |..::|.|:.:     |.|:
Mouse   610 WNTLSEALRRNGKYVNIQEVMDQWTLQMGYPVI---TILGN---TTAENRILITQQHFIYDIGAK 668

  Fly   521 -------NATLKYTVPITFT----TNLERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLRQS 574
                   |::..:.:|:|..    :::..:.......|..|.  .:.:||..|   |||.|:.|:
Mouse   669 TKALQLQNSSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHH--RIAYLDRGS---WILGNINQT 728

  Fly   575 NYQRVFYDDTLRE-GLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEV 638
            .|.||.||  ||. .||:.....||..:.|.|||.:|||.|:.|:|.|:........:.||::|.
Mouse   729 GYFRVNYD--LRNWRLLIDQLIRNHEVLSVSNRAALIDDAFSLARAGYLPQNIPLEIIRYLSEEK 791

  Fly   639 EYVPWYAVYENLNTVAKRLTPEQLPDFRI---YLSSITAAVFEKLGVGWNAQDTPLDVAN----- 695
            :::||:|....|..:.|.|  :::.::.|   |:....|..:.|||...|..:..|..|:
Mouse   792 DFLPWHAASRALYPLDKLL--DRMENYNIFNEYILKQVATTYIKLGWPRNNFNGSLVQASYQHEE 854

  Fly   696 -RNKLIKWLCRYQASNCRPKVNV---QFVTGHEVPSP-DYRETFYC-AASGADYNSYTMLWGQYY 754
             |.::|...|.:...:|..:.:.   .:::.:....| :.|:..|| ..|..|.:.:..:|.:::
Mouse   855 LRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFH 919

  Fly   755 LENRTSEKNMLWAAISCTRDYETHYHKMIISGTESV--EQKKIGIARMYEENP---DLVQAIFEM 814
            .....|||.:|..|::|:.|.......:.:|....|  :|..|.:......||   ||....|.
Mouse   920 STTAVSEKKILLEALTCSDDRNLLSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFR- 983

  Fly   815 ITENIMELAYNFQSWSDTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEK 879
            ....|:...|. ::....:::|:.:.|:..|..:.:.||.|..|   :.|.:....|:::.|||.
Mouse   984 DKWKILNTRYG-EALFMNSKLISGVTEFLNTEGELKELKNFMKS---YDGVASASFSRAVETVEA 1044

  Fly   880 NLNWAETHLEGLVKYL 895
            |:.|...:.:.|.::|
Mouse  1045 NVRWKRFYQDELFQWL 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	126/416 (30%)
		M1_APN_2	34..492	CDD:189008	142/476 (30%)
		ERAP1_C	567..874	CDD:288671	82/326 (25%)
Trhde	NP_666353.2	M1_APN-Q_like	190..635	CDD:341064	139/471 (30%)
Trhde	NP_666353.2	ERAP1_C	720..1044	CDD:378732	85/332 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020