DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42335 and ENPEP

DIOPT Version :9

Sequence 1:NP_732655.3 Gene:CG42335 / 42558 FlyBaseID:FBgn0259237 Length:924 Species:Drosophila melanogaster
Sequence 2:NP_001968.3 Gene:ENPEP / 2028 HGNCID:3355 Length:957 Species:Homo sapiens


Alignment Length:923 Identity:226/923 - (24%)
Similarity:393/923 - (42%) Gaps:129/923 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 DYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITEC-WLLD 87
            ::||...|.|.||:|.:..|   :|...:.|.|||::.:  :...:.:.||.....||.. .|..
Human    90 NFRLPDFVNPVHYDLHVKPL---LEEDTYTGTVSISINL--SAPTRYLWLHLRETRITRLPELKR 149

  Fly    88 AAGAQVEAIDISRLIYEAATQQ-VRVPLTEAAQPGKN---YTLGFKYTGHIRTDMAGFFSASYVE 148
            .:|.||:.    |..:|...|: |.|...|...|...   |.|..::.|.:...:.||:..:|.|
Human   150 PSGDQVQV----RRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTE 210

  Fly   149 RDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFV 213
              ....:.:..|..:..:||...||||||..||.:.:.|..|..|.:::|..:.:.:::......
Human   211 --NGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTR 273

  Fly   214 DHFKETPVMSTYLLAFMVANYSA----RGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQ 274
            ..|:::..|||||:.|.|..:.:    ..:.....:..:||.....|::.::.:.|...:.|.|.
Human   274 TTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFA 338

  Fly   275 SPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMW 339
            ..|:   ...|...:.|.|....|||||||.|.:..|:.:|..|.. |:::....::|||..|.|
Human   339 MNYS---LPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESAS-SNQQRVATVVAHELVHQW 399

  Fly   340 FGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPE 404
            ||:.||..||...||||.||.::|:...:....|:.:.:|.::..:..:...|:...:.|:.   
Human   400 FGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPII--- 461

  Fly   405 SEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFE- 468
            ..:.||.:|...|.||:|:||:.|:||..:.:..|||....:.||::|...|....:.:..|.| 
Human   462 VTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEA 526

  Fly   469 -HWPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSN-----ATLKYT 527
             ..|..:.:|      .:|.|:|||::.|     |.|..:.|.||||  |..:|     :.|.||
Human   527 SRLPVKEVMD------TWTRQMGYPVLNV-----NGVKNITQKRFLL--DPRANPSQPPSDLGYT 578

  Fly   528 --VPITFTTNLERDFYNLTPYKYLHKTVNV-LWLDFTSPID--WILFNLRQSNYQRVFYDDTLRE 587
              :|:.:|.:      |:|.....:::... :.|:.::|..  ::..|.....:.||.|:....:
Human   579 WNIPVKWTED------NITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWD 637

  Fly   588 GLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNT 652
            .:..|:| .||......:||.:|||.|..|:||.:||.......:||.:|..::||..|...:..
Human   638 SIATALS-LNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTY 701

  Fly   653 VAKRL--TPEQLPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVANRNKLIKWLCRY---QASNCR 712
            :....  ..|..|....|.......:.:.|  |||.....:....|:.::.:.|:.   :|.|..
Human   702 IISMFEDDKELYPMIEEYFQGQVKPIADSL--GWNDAGDHVTKLLRSSVLGFACKMGDREALNNA 764

  Fly   713 PKVNVQFVTGHEVPSP------DYRETFYCAASGADYNSYTMLWGQYYLENRTSEKNMLWAAISC 771
            ..:..|::.| .|..|      .||.....:.:...:| ||:  .||...:...||..|      
Human   765 SSLFEQWLNG-TVSLPVNLRLLVYRYGMQNSGNEISWN-YTL--EQYQKTSLAQEKEKL------ 819

  Fly   772 TRDYETHYHKMIISGTESVEQKKIGIARMY-----EENPDLVQAIFEMITENIMELAYNF----Q 827
                        :.|..||  |.:.:...|     :.|....|.:|.:    |..::||.    .
Human   820 ------------LYGLASV--KNVTLLSRYLDLLKDTNLIKTQDVFTV----IRYISYNSYGKNM 866

  Fly   828 SWS------------------DTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSL 874
            :|:                  :...::. :||.|.| |.|....|.:::.:...|..|:...:.|
Human   867 AWNWIQLNWDYLVNRYTLNNRNLGRIVT-IAEPFNT-ELQLWQMESFFAKYPQAGAGEKPREQVL 929

  Fly   875 VTVEKNLNWAETH 887
            .||:.|:.|.:.|
Human   930 ETVKNNIEWLKQH 942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42335NP_732655.3 Peptidase_M1 26..425 CDD:279741 109/407 (27%)
M1_APN_2 34..492 CDD:189008 124/468 (26%)
ERAP1_C 567..874 CDD:288671 71/344 (21%)
ENPEPNP_001968.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 44..83
Peptidase_M1 92..482 CDD:279741 109/407 (27%)
M1_APN_2 100..545 CDD:189008 124/468 (26%)
Substrate binding. /evidence=ECO:0000269|PubMed:23888046, ECO:0007744|PDB:4KXA, ECO:0007744|PDB:4KXB, ECO:0007744|PDB:4KXC, ECO:0007744|PDB:4KXD 357..361 1/3 (33%)
ERAP1_C 617..931 CDD:288671 72/346 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
55.020

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