DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42335 and Npepps

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_032968.2	Gene:	Npepps / 19155	MGIID:	1101358	Length:	920	Species:	Mus musculus

Alignment Length:	923	Identity:	233/923 - (25%)
Similarity:	395/923 - (42%)	Gaps:	107/923 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAG 90
            ||...|.|.:|:|   .|:..:....|:|::....:|  .....||:::...:||..........
Mouse    54 RLPAEVSPINYSL---CLKPDLLDFTFEGKLEAAAQV--RQATNQIVMNCADIDIITASYAPEGD 113

  Fly    91 AQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVTR 155
            .::.|...:   |:...::|.:......|.|.. ||...:.|.:...|.||:.:.|......| |
Mouse   114 EEIHATGFN---YQNEDEKVTLSFPSTLQTGTG-TLKIDFVGELNDKMKGFYRSRYTTPAGEV-R 173

  Fly   156 WLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQD-RFVD-HFKE 218
            :.|:||.:..:||...||:||||:||.|.:.:|.|....:::|..:.:.|....| ..|: .|..
Mouse   174 YAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFAR 238

  Fly   219 TPVMSTYLLAFMVANYSARGNESEFAVLTRPEFY------DNTEFSYHVGQQVVSAYGELFQSPY 277
            ||||||||:||:|..|......|:..|..|  .|      :..:|:..|..:.:..|.:.|..||
Mouse   239 TPVMSTYLVAFVVGEYDFVETRSKDGVCVR--VYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPY 301

  Fly   278 AELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGD 342
            .....|::..|.   |....||||||:.|.:..|:.:|..|.. |.:::...::.||.:|.|||:
Mouse   302 PLPKIDLIAIAD---FAAGAMENWGLVTYRETALLIDPKNSCS-SSRQWVALVVGHELAHQWFGN 362

  Fly   343 SVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFV----VRQMQLIFGTDAQNGTQPMTSP 403
            .||..||::.||||.||.:.||......:|:|.:..|||    .|..:|    ||.:.:.|:
Mouse   363 LVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQEL----DALDNSHPI--- 420

  Fly   404 ESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFE 468
            |..:..||::...|..|:|:|||.::||..:.:|.::|...:..||.::...|....:|
Mouse   421 EVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDL------ 479

  Fly   469 HWPKNQDVD---LVDFLTDYTEQVGYPMIIVKA--LQGNKVVTVEQSRFLLNKDDGSNATLKYTV 528
             |...:...   :...:..:|:|:|:|:|.|:|  ::.::|:.:.|.:|..:...|.....::.|
Mouse   480 -WESLESASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCASGPYGGEDCPQWMV 543

  Fly   529 PITFTTNLERDFYNLTPYKYL-HKTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTLREGLLLA 592
            |||.:|:.:.   |....|.| .|....:.|....|..|:..||....:.|..|...:.|.||..
Mouse   544 PITISTSEDP---NQAKLKILMDKPEMSVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPG 605

  Fly   593 ISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTVAKRL 657
            |   ....:|..:|..:.:|||:.|:|..:...:|.:.:|....|..|..|..:..||..::..|
Mouse   606 I---RDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLL 667

  Fly   658 TPEQLPDFRIYLSSITAAVFEKLG--VGWNAQ--DTPLDVANR----NKLIKWLCRYQASNCRPK 714
            :.   .||...:......||..:|  :||:.:  :..||...|    .||.|...:......|.:
Mouse   668 SH---TDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRR 729

  Fly   715 VNVQFVTGHEVPSPDYRETFYCA----ASGADYNSYTMLWGQYYLENRTSEKNMLWAAISCTRDY 775
            .. :.|.|.::.|.|.|...|..    ..||..:....|..|..::   .|||.:
Mouse   730 FK-EHVEGKQILSADLRSPVYLTVLKHGDGATLDIMLKLHKQADMQ---EEKNRI---------- 780

  Fly   776 ETHYHKMIISGTESVE--QKKIGIARMYEENP-DLV--------------QAIFEMITENIMELA 823
                 :.::..|.|.|  ||.:..|...|..| |.|              :|.::.|.:|..||.
Mouse   781 -----ERVLGATLSPELIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELH 840

  Fly   824 YNFQSWSDTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNWAETHL 888
            ..:|.....:.:|....|.|...:....:|.|:.|:..  ..:|..:.:....:..|..|.:...
Mouse   841 NRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPA--PSAERTIQQCCENILLNAAWLKRDA 903

  Fly   889 EGLVKYLADRNGS 901
            :.:.:||..|..|
Mouse   904 DSIHQYLLQRKTS 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	119/410 (29%)
		M1_APN_2	34..492	CDD:189008	130/472 (28%)
		ERAP1_C	567..874	CDD:288671	73/335 (22%)
Npepps	NP_032968.2	Peptidase_M1	54..442	CDD:279741	119/410 (29%)
		M1_APN_2	62..505	CDD:189008	130/472 (28%)
		Substrate binding. /evidence=ECO:0000250	317..321		1/3 (33%)
		ERAP1_C	580..891	CDD:288671	73/337 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920