DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42335 and T12E12.6

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_500831.2	Gene:	T12E12.6 / 188454	WormBaseID:	WBGene00020465	Length:	641	Species:	Caenorhabditis elegans

Alignment Length:	678	Identity:	142/678 - (20%)
Similarity:	254/678 - (37%)	Gaps:	165/678 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSSIFRAFWLLCSLLICVTNAADYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGT 65
            |.||.|     |..||....|:..:    :::|..|:|...:..:.     |:|       ..|:
Worm     1 MKSSFF-----LVLLLFQTANSWPH----NIIPLSYDLLFKLPIHE-----FNG-------FTGS 44

  Fly    66 LEVQQIILHADTLDITECWLLDAAG-------AQVEAIDISRLIYEA---ATQQVRVPLTEAAQP 120
            :     :||.:...:::...|||..       :.:.:.|::....::   ..::|.:...::..|
Worm    45 M-----VLHFNLSSLSDNITLDAVDLHSFRNISLIRSADLTEPTLKSIKILKEKVELKFEKSLFP 104

  Fly   121 GKN-YTLGFKYTGHIRTDMAGFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQ 184
            |:. .|:| :|.|.|     |..|.:..||...:   |..|.:|..:||.:.||.|.||:||.|:
Worm   105 GQYLLTIG-EYNGRI-----GNSSEALFERRNPL---LYTTHLQPNHARRLFPCIDHPAVKALFR 160

  Fly   185 LQIVRPNGYQSIANTKLKETKALSQDRFVDH-------FKETPVMSTYLLAFMVANYS--ARGNE 240
            |.||.|....:.:||       ::.|..|::       |:.||::..||:||.|...|  ....:
Worm   161 LSIVHPTDTVAQSNT-------IAMDVHVENRKWQRTIFQATPLLPAYLVAFSVMPDSNLQLSRQ 218

  Fly   241 SEFAVLTRP---------EFYDNTEFSYHVGQQVVSAYGELFQSPYAELGNDVLQYASSPRFPHN 296
            :.|.|..|.         ...|....|:.:       ...|...|   |..:.:.:...|.: ..
Worm   219 TSFGVTVRVNGESRGLVLRVLDCALASFEI-------LAGLIDVP---LPLNKIDFILVPEY-DG 272

  Fly   297 GMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARY 361
            ||||||.|..|:.:...        .|....|.:||||.:|.|.|:..|...|::..|.|....:
Worm   273 GMENWGHITVSETLATS--------GDDAHLIYLIAHEIAHHWIGNRATIDSWNWICLQEDLTDW 329

  Fly   362 YEYFMAHQLYPDYHLDEQFVVRQ---MQLIFGTDAQNGTQPMTSPESEIQTPSQIAYK-FSGIAY 422
            ........|..|....::|.:.|   :||:         :...||...:..||:|..: .:...|
Worm   330 MALKAVKALLTDEIRLQRFQLAQYVEIQLV---------EDFLSPGHSLYMPSKINQELINRHCY 385

  Fly   423 AKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFY------------HLFEHWPKNQD 475
            .||..::....:::|.:...:.|:|.:..:...|...:..::            .::|:|
Worm   386 LKGVVLLDTLESVVGEQFMYSVIKSLVGSHSTYNLTTFTSYFDQIRVDRNATVGQIYEYW----- 445

  Fly   476 VDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNATLKYTV----PITFTTNL 536
                     ||.. |||.|:|                   :::|.::.|:...    |:..|:.|
Worm   446 ---------YTTG-GYPSILV-------------------ENNGPSSRLQQLSRPLWPLKMTSTL 481

  Fly   537 ERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTLREGLLLAISATNHSGI 601
            .     :..:.:....|      |.|....:|.||..:::.||.| |:|....:...........
Worm   482 A-----IPQFVFSESIV------FASENAPLLVNLNFTSFMRVNY-DSLTWTAIFKYMFEEPELF 534

  Fly   602 PVENRAQIIDDLFNFAQAQYVDYADVFR 629
            ....|||::.|...|.....||...:.:
Worm   535 SAVGRAQLVSDFCYFYANDKVDNGTILK 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	96/431 (22%)
		M1_APN_2	34..492	CDD:189008	106/502 (21%)
		ERAP1_C	567..874	CDD:288671	15/63 (24%)
T12E12.6	NP_500831.2	GluZincin	25..402	CDD:387391	98/437 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020