DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and anp-1

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001041160.1	Gene:	anp-1 / 179763	WormBaseID:	WBGene00011587	Length:	988	Species:	Caenorhabditis elegans

Alignment Length:	980	Identity:	242/980 - (24%)
Similarity:	421/980 - (42%)	Gaps:	179/980 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NAADYRLEGSVVPSHYNLTIGVL---------RNSVEPTIFDGEVSITLRVVGTLEVQQIILHAD 76
            :|::.||..||.|..|.||:...         :|::   .|:|:|.|.|.:  |..::::.|::.
Worm    80 SASELRLPTSVSPISYQLTVKTYLPGYGYTADKNNL---TFEGQVLIELNI--TKSIKKVSLNSK 139

  Fly    77 TLDITECWLLDAA----GAQVE-AIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRT 136
            .|:.||.::..::    |..:. .:|..:..:|    ::...|.|..:|..:.||...:...:||
Worm   140 DLNYTEEFIKKSSILVNGKSIAFTLDDKQSTHE----KIFFNLDETVEPTTSATLKVAFGAPLRT 200

  Fly   137 DMAGFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIAN--- 198
            ||:|.:..:|. .....::..|:|||:.:.||.::|||||||.||.:.:.::.||...:::|
Worm   201 DMSGLYQTTYT-NSKGESKMAAVTQMEPVYARRMVPCFDEPAYKATWTVTVIHPNKTVAVSNGIE 264

  Fly   199 TKLKETKALSQDRF-VDHFKETPVMSTYLLAFMVANYSARGNES------EFAVLTRPEFYDNTE 256
            .|:::    .|..| :..||.||.||:||||..::.:..  ||:      .|.|.:|||..::|.
Worm   265 DKVED----GQPGFIISTFKPTPRMSSYLLAIFISEFEY--NEATTKSGVRFRVWSRPEEKNSTM 323

  Fly   257 FSYHVGQQVVSAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPG-YSDD 320
            ::...|.:.:..|.:.:...:.....|::   :.|.|....|||||||.|.:..|:.:|. ||.
Worm   324 YAVEAGVKCLEYYEKYYNISFPLPKQDMV---ALPDFSAGAMENWGLITYRESALLYDPRIYSG- 384

  Fly   321 WSDKEFAIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYP-DYHLDEQFVVRQ 384
             |.|.....:||||.:|.|||:.||..||:..||||.||...||....::.. :..:.|.|.:..
Worm   385 -SQKRRVAVVIAHELAHQWFGNLVTLKWWNDLWLNEGFATLVEYLGTDEISDGNMRMREWFTMDA 448

  Fly   385 MQLIFGTDAQNGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYL 449
            :......|:...|.|:|   .:|....::...|..:.|.||..::.|.|..:|.|||:|.|..||
Worm   449 LWSALAADSVASTHPLT---FKIDKAMEVLDSFDSVTYDKGGAVLAMVRKTIGEENFNTGINHYL 510

  Fly   450 QQYHLTNTVPYNLFYHLFEH------WPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVE 508
            .::...|....||...|.|.      .||...:::.:|:..:|:|:|||::....:....:: ||
Worm   511 TRHQFDNADAGNLLTALGEKIPDSVMGPKGVKLNISEFMDPWTKQLGYPLLNASRINNTHII-VE 574

  Fly   509 QSRFLL-----NKDDGSNAT--LKYTVPITF----TTNLERDFYNLTPYKYLHKTVNVLWLDFTS 562
            ||||.|     .::..||..  .|:.||:.:    ::.||                 :.|:....
Worm   575 QSRFKLLATGKEEEKYSNPVWGFKWDVPVWYQVVGSSELE-----------------MKWMKRNE 622

  Fly   563 PI-----DWILFNLRQSNYQRVFYDDTLREGLLLAIS---ATNHSGIPVENRAQIIDDLFNFAQA 619
            |:     ..::.|...:.:.|..|.    .||...||   ..||.....:.|.::|||.|..|:|
Worm   623 PLIIKSDKNVIINAESNGFYRAGYS----SGLWKEISEMLKENHEQFSPQTRVRLIDDSFALARA 683

  Fly   620 QYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTVAKRLTPEQLPDFRIYLSSITAAVFEKLGVGW 684
            ..:.|:.....:.||..|.||:||......:         .:|.|  :|.|:....:..|..:..
Worm   684 GLLSYSIPLNLITYLKNEKEYLPWSGAIAKI---------RELID--MYGSNPEKDIVNKFMIAL 737

  Fly   685 NAQDTP----LDVANRN--------------KLIKWLCRYQASNCRPKVNVQFVTG--------- 722
             |::.|    :|..::|              ::|...|.:..|.|:..:...|...
Worm   738 -AENAPARRSIDFVSKNYLDEKKFYEVGAAQQIILNSCGFGDSVCQADMVKMFTEEVLAKCDATR 801

  Fly   723 -----HEVPSPDYRETFYC-AASGADYNSYTMLWGQYYLENRTSEKNMLWAAISCTRDYETHYHK 781
                 .::|:| :|...|| |....:.:::..::..|..|....||..|..|::|::|..|
Worm   802 ILSECSQIPAP-FRAESYCEAVRNGNSDTFEKVFHWYKTERNQVEKLNLMTALTCSKDILT---- 861

  Fly   782 MIISGTESVEQKKIGIARMYEENPDL----VQAIFEMITEN--IMELAYNF--QSWSDT------ 832
                      .||:.:..|..|....    ..|:|..|:.|  ..:...||  ..|.|.
Worm   862 ----------LKKLLLDAMKPEGSSFRLQDCAALFAKISSNDATTDAMLNFLIDRWEDMQKRLAT 916

  Fly   833 -----AEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNWAETHLEGLV 892
                 :.|::.:.....||.....|::|.....:   .||..|.|...:.|..:.|.||:|:.:.
Worm   917 DHSGFSRVLSSIVNTLKTRGGLDQLRKFRKKAPK---ASEFGLDKMEESAEVTVTWRETNLKFVT 978

  Fly   893 KYLAD 897
            |.:.:
Worm   979 KIIEE 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	120/424 (28%)
		M1_APN_2	34..492	CDD:189008	138/489 (28%)
		ERAP1_C	567..874	CDD:288671	74/361 (20%)
anp-1	NP_001041160.1	Peptidase_M1	85..486	CDD:279741	120/424 (28%)
		M1_APN_2	93..559	CDD:189008	138/489 (28%)
		ERAP1_C	632..964	CDD:288671	74/365 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020