DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and Y42A5A.1

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_505820.1	Gene:	Y42A5A.1 / 179536	WormBaseID:	WBGene00012776	Length:	1045	Species:	Caenorhabditis elegans

Alignment Length:	942	Identity:	240/942 - (25%)
Similarity:	379/942 - (40%)	Gaps:	167/942 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NAADYRLEGSVVPS-HYNLTIGV-LRNSV--EPTIFDGEVSITLRVVGTLEV-------QQIILH 74
            |..::||:   :|. |..|...| |:..|  .|||..|  |....|.|.:.|       .:|:||
Worm   145 NNTNHRLQ---IPQIHIPLLYEVELKLFVPWRPTISFG--SDNFSVKGHVRVHFTSGGGSRILLH 204

  Fly    75 ADTLD-ITECWLLDAAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDM 138
            :|:.. |.:|.:.|.....:..    :|:....:|.:.:.|......|.||||...:...|..::
Worm   205 SDSKQHIGDCVVRDELNRNITV----KLVGRQYSQILDLNLETDMIHGMNYTLDVAFKSAINLNL 265

  Fly   139 A-GFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLK 202
            | |.|:|.|...  |.||::..||:|...||.|.||.|.|.:||||...|:.|.|..||||....
Worm   266 AYGLFAAPYTFE--NETRYVVATQLQISEARTVFPCIDVPDMKAQFDTVIIHPTGTTSIANMMEN 328

  Fly   203 ETKALSQDRFVDHFKETPVMSTYLLAFMVANY------SARGNESEFAVLTRP-EFYDNTEFSYH 260
            .|| :..:.....|..||.|||||.||.|::|      |.||..|.  |...| :..|....:..
Worm   329 STK-VDGEWTTTTFHRTPPMSTYLFAFSVSDYPYLETFSGRGVRSR--VYCDPTKLVDAQLITKS 390

  Fly   261 VGQQVVSAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKE 325
            :| .|:..|.:.|..||.   .:.|.....|......|||||||     .:.|..|.   :::..
Worm   391 IG-PVLDFYEDYFGIPYP---LEKLDVVIVPALSVTAMENWGLI-----TIRQTNGL---YTEGR 443

  Fly   326 FAI-------RIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEY----FMAHQL--YPDYHLD 377
            |||       .|:|||.:|.|||:.||..||:..||||.||.....    |:.:..  |.|...:
Worm   444 FAISQKHDVQEIVAHELAHQWFGNLVTMKWWNDLWLNEGFATLISVRAVDFLENTTWRYEDSSAE 508

  Fly   378 EQFVVRQMQLIFGTDAQNGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFD 442
            .|.|..:      .|..:...|::..::. ...|.:..:...|.|.|.|.|:||...|:..:.|.
Worm   509 SQCVALR------ADQIDSISPVSGKKNS-NFDSYMEIQGKAIIYKKSAIIIRMIERLVEEDIFR 566

  Fly   443 TAIRSYLQQYHLTNTVPYNLFY------------HLFEHWPKNQDVDLVDFLTDYTEQVGYPMII 495
            ..::.:|..:...|....:||.            ||     :.|:..|.|.:..:..|..:|:|.
Worm   567 QGLKRFLNTFLYKNADHEDLFNVLVYVHDSSAGGHL-----RGQNFSLSDVMDTWIRQAHFPVIH 626

  Fly   496 VKALQGNKVVTVEQSRF-LLNKDDGSNATLKYTVPITFTTNLERDFYNLTPYKYLHKTVNVLWLD 559
            |...:|: :||:.|.:: .:.:|:......|  :||         ||: .|....||   |.||.
Worm   627 VNRKEGS-LVTLRQEKYEHVPRDEPEKQVWK--IPI---------FYD-DPVSGKHK---VFWLT 675

  Fly   560 FTSP--IDW---ILFNLRQSNYQRVFYDDTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQA 619
            .|.|  .|.   ::.:..|..|.|:.||..:...:.:|: ..:.:.||..:|:::|||....|:.
Worm   676 DTQPKVFDMGGLLVVDPHQLTYMRLRYDMEMYSDITMAL-MDDFTMIPTNSRSRLIDDTLAMAEN 739

  Fly   620 QYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTVAKRL-TPEQLPDFRIYLSSITAAVFEKLGVG 683
            ..:.|...|....|:::|:.|.|:......|:....|: ..|....::.||..:....|:|
Worm   740 GQLTYKVPFNLTMYMSREIAYRPFQTFSAYLDFFLPRMYIHEGWSIYKKYLELVVGIPFDK---- 800

  Fly   684 WNAQDTPLDVANRNKLIKWLCRYQASNCRPKVNVQFVTGHEVPSPDYRETFYCAASGADYNSYTM 748
            :||:.  |||:                          ..|.......|:.....|.|.:|.....
Worm   801 FNAEG--LDVS--------------------------FDHNTDLFHTRQIVVFRACGIEYEPCVR 837

  Fly   749 LWGQYYLENRT--SEKNMLWAAISCTR-DY--ETH-YHKMIISGTE---SVEQKKIGIARMYEEN 804
            :..|.:.|.|.  |.:|.|.:.:.|.: .|  ..| |...|..||:   ....||..|.....|:
Worm   838 MAKQRFAELRVNCSGENQLLSGMECNKIPYYLRPHVYSAAINDGTQEDFDFLYKKWMIEHYMMEH 902

  Fly   805 PDLVQAIFEMITENIMELAYNFQSWSDTAEVINDMAEYFTTREQ--------QQLLKEFYYSNHQ 861
            .::...   :.|.||.|  .:.::|...  :.|...|....|.|        ...:.:..|.:..
Worm   903 DNIFTG---LCTTNIRE--NSDRAWRQV--IKNGARENVMVRAQLCSKKLSKNNFILDLLYEDKV 960

  Fly   862 FFGESEELLSKSLVTVE----KNLNWAETHLE 889
            :..|..:...|||..::    :.:|:.|..|:
Worm   961 YLKEFVDKDRKSLFALQQLLYRKINYEEEVLK 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	130/431 (30%)
		M1_APN_2	34..492	CDD:189008	144/502 (29%)
		ERAP1_C	567..874	CDD:288671	65/324 (20%)
Y42A5A.1	NP_505820.1	Peptidase_M1	159..549	CDD:279741	126/419 (30%)
		M1_APN_2	181..623	CDD:189008	134/474 (28%)
		ERAP1_C	688..998	CDD:288671	70/345 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020