DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42335 and pam-1

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001023210.1	Gene:	pam-1 / 177528	WormBaseID:	WBGene00003914	Length:	948	Species:	Caenorhabditis elegans

Alignment Length:	673	Identity:	186/673 - (27%)
Similarity:	319/673 - (47%)	Gaps:	55/673 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAG 90
            ||.....|:|||:.:....|...   |||..:|.:.:....:|.::  ||.:|.|....|:...|
Worm    79 RLPTFAEPTHYNVRLSPCLNQFS---FDGHATIDVTIKEATDVLKV--HAQSLLIQSVSLITQPG 138

  Fly    91 AQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVT- 154
            ...::::.|   |:.....:.:.|....||.| ..|.||:.|.:...|.||:.:.|  :|.|.|
Worm   139 DASKSLETS---YDDKLNILTIKLPTTMQPQK-VQLDFKFVGELNDKMRGFYRSQY--KDKNGTE 197

  Fly   155 RWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTK-LKETKALSQDRFVDHFKE 218
            ::||.||.:...||...||||||..||.|.:.:...|...:::|.. :.||......|....|..
Worm   198 KFLASTQFESTYARYAFPCFDEPIYKATFDVTLEVENHLTALSNMNVISETPTADGKRKAVTFAT 262

  Fly   219 TPVMSTYLLAFMVA--NYSARGNES--EFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYAE 279
            :|.||:||:||.|.  .|.:...:|  |..|.|.|...:..::|..:..:.:..|.|.|...|..
Worm   263 SPKMSSYLVAFAVGELEYISAQTKSGVEMRVYTVPGKKEQGQYSLDLSVKCIDWYNEWFDIKYPL 327

  Fly   280 LGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDSV 344
            ...|::   :.|.|....||||||:.|.:..|:.:||.:........|: ::|||.:|:|||:.|
Worm   328 PKCDLI---AIPDFSMGAMENWGLVTYREIALLVDPGVTSTRQKSRVAL-VVAHELAHLWFGNLV 388

  Fly   345 TFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESEIQT 409
            |..||:..||.|.||.:.||.......|::.:...|:..::....|.||...:.|:   |.||..
Worm   389 TMKWWTDLWLKEGFASFMEYMFVGANCPEFKIWLHFLNDELASGMGLDALRNSHPI---EVEIDN 450

  Fly   410 PSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHWPKNQ 474
            |:::...:..|.|||...:.||....:....|...:|.||:::..:|.|..:|:..|.|  ...|
Worm   451 PNELDEIYDSITYAKSNSVNRMLCYYLSEPVFQKGLRLYLKRFQYSNAVTQDLWTALSE--ASGQ 513

  Fly   475 DVDLVDFLTDYTEQVGYPMIIVKALQ--GNKVVTVEQSRFLLN-KDDGSNATLKYTVPITFT--- 533
            :|:  :.::.:|:|:|:|::.|...|  .|:::||||.||:.: .:|..|:  ::.||||..
Worm   514 NVN--ELMSGWTQQMGFPVLKVSQRQDGNNRILTVEQRRFISDGGEDPKNS--QWQVPITVAVGS 574

  Fly   534 --TNLERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTLREGLLLAISAT 596
              ::::..|       .|.:......::..:|.:|:..|...:.:.||.|.|.:...:|..|::.
Worm   575 SPSDVKARF-------LLKEKQQEFTIEGVAPGEWVKLNSGTTGFYRVEYSDEMLTAMLPDIASR 632

  Fly   597 NHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTV---AKRLT 658
            .   :||.:|..:|:||........|..|...:.....|||.|||.|.|:.|.::.:   |:.::
Worm   633 R---MPVLDRFGLINDLSALLNTGRVSIAQFVQVAASSAKEDEYVVWGAIDEGMSKLLACAREMS 694

  Fly   659 PEQLPDFRIYLSSITAAVFEKLG 681
            .:.|...:    .:...:||:.|
Worm   695 EDTLKSAK----QLVVKMFEQTG 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	120/404 (30%)
		M1_APN_2	34..492	CDD:189008	134/463 (29%)
		ERAP1_C	567..874	CDD:288671	29/118 (25%)
pam-1	NP_001023210.1	M1_APN_2	87..529	CDD:189008	134/463 (29%)
pam-1	NP_001023210.1	ERAP1_C	602..927	CDD:314669	30/119 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020