DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42335 and Lnpep

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001106874.1	Gene:	Lnpep / 171105	RGDID:	621752	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	932	Identity:	230/932 - (24%)
Similarity:	407/932 - (43%)	Gaps:	129/932 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ADYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLD 87
            |..||..:::|..|.|:   |..::....|.|.|:|:|:.:  .:.:.||||:...:|:....:.
  Rat   164 AQIRLPTAIIPQRYELS---LHPNLTSMTFRGSVTISLQAL--QDTRDIILHSTGHNISSVTFMS 223

  Fly    88 AAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTN 152
            |..:|.:.::|....|.   :|:.|...|:...|.||||..:|:.:|.....||:..:|.:: :|
  Rat   224 AVSSQEKQVEILEYPYH---EQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDK-SN 284

  Fly   153 VTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDHFK 217
            ..:..|.||.:.:.||...|||||||.||.|.::|.|...:.:::|...|.:....:....|.|.
  Rat   285 EKKNFAATQFEPLAARSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFS 349

  Fly   218 ETPVMSTYLLAFMVA---NYSARGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYAE 279
            |:..|||||:||:|.   |.|...|.:..:|...||..|..   ||.....|... |.:|: |.|
  Rat   350 ESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYAVPEKIDQV---YHALDTTVKLL-EFYQN-YFE 409

  Fly   280 LGNDV--LQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGD 342
            :...:  |...:.|.|....||||||:.:.::.|:.:...| ..:|::...:|||||.:|.|||:
  Rat   410 IQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATS-SVADRKLVTKIIAHELAHQWFGN 473

  Fly   343 SVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESEI 407
            .||..||:..||||.||.:.|||...:::.:.:..|.|:..:.:.: ..|:.|.:.|::   |.:
  Rat   474 LVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTM-RKDSLNSSHPIS---SSV 534

  Fly   408 QTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHWPK 472
            |:..||...|..::|.|||.::.|.::.:..:.|..||..||..:........:|:....|...|
  Rat   535 QSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGK 599

  Fly   473 NQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKD---DGSNATLKYTVPITFTT 534
            ..||.  ..:..:|.|.|:|::.|:. :|.::: ::|.||..:..   ..|:.:..:.:||::.|
  Rat   600 TLDVK--KMMKTWTLQKGFPLVTVQR-KGTELL-LQQERFFPSMQPEIQDSDTSHLWHIPISYVT 660

  Fly   535 NLERDFYNLTPYK---YLHKTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTLREGLLLAIS-- 594
                |..|.:.|:   .|.|..:|  ::.|..:.|:..|...:.|..|.|   ..:|....|:
  Rat   661 ----DGRNYSEYRSVSLLDKKSDV--INLTEQVQWVKVNTNMTGYYIVHY---AHDGWAALINQL 716

  Fly   595 ATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNTVAKRLTP 659
            ..|...:..::||.:|:::|..|....|.....|..::||..|....|
  Rat   717 KRNPYVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAP----------------- 764

  Fly   660 EQLPDFRIYLSSITAAVF---------EKLG----------------------VGWNAQDTPLDV 693
                        ||.|:|         ||||                      ..|..:.||...
  Rat   765 ------------ITEALFQTDLIYNLLEKLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMR 817

  Fly   694 ANRNKLIKWLCRYQASNCRPKVNVQF-----VTGHEVPSPDYRETFYCAASGADYNSYTMLWGQY 753
            ..|:.|:::.|.:...||.......|     ..|.:....|...|.:...:..: ..:..|:..|
  Rat   818 ELRSALLEFACAHSLENCTTMATKLFDGWMASNGTQSLPTDVMTTVFKVGARTE-KGWLFLFSMY 881

  Fly   754 YLENRTSEKNMLWAAISCTRDYETHY--HKMIISGTESVEQKKIG--IARMYEENPDLVQAIFEM 814
            ......:||:.:..|::.:.|....|  .|..:.| :.:..:|:.  |..:..:.|..:.| ::.
  Rat   882 SSMGSEAEKDKILEALASSADAHKLYWLMKSSLDG-DIIRTQKLSLIIRTVGRQFPGHLLA-WDF 944

  Fly   815 ITENIMELAYNFQSWSDTAE-VINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELL-----SKS 873
            :.||..:|.:.|...|.|.: ::......|:|:.....::||      |..:||..|     .::
  Rat   945 VKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQEF------FENQSEATLQLRCVQEA 1003

  Fly   874 LVTVEKNLNWAETHLEGLVKYL 895
            ...:|.|:.|...:|:.|..:|
  Rat  1004 FEVIELNIQWMARNLKTLTLWL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	123/403 (31%)
		M1_APN_2	34..492	CDD:189008	137/462 (30%)
		ERAP1_C	567..874	CDD:288671	65/354 (18%)
Lnpep	NP_001106874.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	123/403 (31%)
		M1_APN_2	176..617	CDD:189008	137/461 (30%)
		Substrate binding. /evidence=ECO:0000250	428..432		1/3 (33%)
		ERAP1_C	690..1005	CDD:288671	65/355 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020