DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42335 and Anpep

DIOPT Version :10

Sequence 1:NP_732655.3 Gene:CG42335 / 42558 FlyBaseID:FBgn0259237 Length:924 Species:Drosophila melanogaster
Sequence 2:NP_032512.2 Gene:Anpep / 16790 MGIID:5000466 Length:966 Species:Mus musculus


Alignment Length:957 Identity:267/957 - (27%)
Similarity:424/957 - (44%) Gaps:147/957 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 YRLEGSVVPSHYNLTIGVLRNSVEPT-----IFDGEVSITLRVVGTLEVQQIILHADTLDIT--- 81
            |||..:::|..|.:   :||..:.|.     ||.|..::......|.:|  ||:|:..|:.|   
Mouse    74 YRLPKTLIPDSYRV---ILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDV--IIIHSKKLNYTLKG 133

  Fly    82 --ECWLLDAAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSA 144
              ...|....|.....||.:.|:  ..|:.:.|.|..:...|:.|.:..::.|.:..|:|||:.:
Mouse   134 NHRVVLRTLDGTPAPNIDKTELV--ERTEYLVVHLQGSLVEGRQYEMDSQFQGELADDLAGFYRS 196

  Fly   145 SYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQ 209
            .|:|.|  |.:.:|.||||..:||...|||||||:||.|.:.::.||...:::|...||:|...:
Mouse   197 EYMEGD--VKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNLIALSNMLPKESKPYPE 259

  Fly   210 DR--FVDHFKETPVMSTYLLAFMVANY----SARGNESEFAVLTRPEFYDNTEFSY--HVGQQVV 266
            |.  .:..|..||.|||||||::|:.:    |...|..:..:..||...|..:..|  :|...::
Mouse   260 DPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQIGIWARPSAIDEGQGDYALNVTGPIL 324

  Fly   267 SAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRII 331
            :.:.:.:.:.|....:|.:   :.|.|....||||||:.|.:..|:.: ..|...|:||..:.:|
Mouse   325 NFFAQHYNTSYPLPKSDQI---ALPDFNAGAMENWGLVTYRESSLVFD-SQSSSISNKERVVTVI 385

  Fly   332 AHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNG 396
            |||.:|.|||:.||.:||:..||||.||.|.||..|....|.::|.:..|:..:..:...||...
Mouse   386 AHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALAS 450

  Fly   397 TQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYN 461
            :.|::||..||:||.||...|..|.|:|||.::||..:.:..:.|...:.|||..|..:|||   
Mouse   451 SHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTV--- 512

  Fly   462 LFYHLFEHWPK--NQDVDL-----VDFLTD-YTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDD 518
             :..|:||..|  ||...:     |..:.| :..|:|:|:|.|....|.    :.|..|||  |.
Mouse   513 -YLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITVNTNTGE----ISQKHFLL--DS 570

  Fly   519 GSNATLK------YTVPITFTTNLERDFYNLTPYKYLHKTVNVLWLDF---------TSPIDWIL 568
            .||.|..      :..||.|..:.:.|.|               |||.         ||..:|||
Mouse   571 KSNVTRPSEFNYIWIAPIPFLKSGQEDHY---------------WLDVEKNQSAKFQTSSNEWIL 620

  Fly   569 FNLRQSNYQRVFYDDTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEY 633
            .|:..:.|..|.||:...:.|...:. |:.|.|||.||||||.|.||.|.|:.:..........:
Mouse   621 LNINVTGYYLVNYDENNWKKLQNQLQ-TDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLF 684

  Fly   634 LAKEVEYVPWYAVYENLNTVA------------KRLTPEQLPDFRIYLSSITAAVFEKLGVGW-N 685
            |.||.||:||.|...:||...            ||...:|:.....|        |:.....| |
Mouse   685 LVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFY--------FQNRTNNWVN 741

  Fly   686 AQDTPLDVANRNKLIKWLCRYQASNCRPKVNVQFVTGHEVPS-----PDYRETFYC--AASGADY 743
            ...|.::..|....|...|......||..|...:....:.|:     |:.|.|.||  .|.|.: 
Mouse   742 RPPTLMEQYNEINAISTACSSGLKECRDLVVELYSQWMKNPNNNTIHPNLRSTVYCNAIAFGGE- 805

  Fly   744 NSYTMLWGQYYLENRTSEKNMLWAAISCTRDYETHYHKMIISGTESVEQKKIGIARMYEENPDLV 808
            ..:...|.|:......:|.:.|.:|::|::|.      .|::...|           |..|||.:
Mouse   806 EEWNFAWEQFRNATLVNEADKLRSALACSKDV------WILNRYLS-----------YTLNPDYI 853

  Fly   809 Q-------------------AIFEMITENIMELAYNFQSWS-DTAEVINDMAEYFTTREQQQLLK 853
            :                   .:::.:..|..:|..|:...| ..|.:|..:...|::..:.|.|:
Mouse   854 RKQDTTSTIISIASNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLE 918

  Fly   854 EFYYSNHQF-FGESEELLSKSLVTVEKNLNWAETHLEGLVKYLADRN 899
            :|...|... ||.....|.::|.....|::|.:.:.:.:.|:..:.:
Mouse   919 QFKADNSATGFGTGTRALEQALEKTRANIDWVKENKDAVFKWFTENS 965

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42335NP_732655.3 M1_APN-Q_like 34..487 CDD:341064 151/478 (32%)
ERAP1_C 566..878 CDD:463368 85/352 (24%)
AnpepNP_032512.2 Cytosolic Ser/Thr-rich junction 33..68
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..64
Metalloprotease 69..966 267/957 (28%)
M1_APN-Q_like 84..545 CDD:341064 151/477 (32%)
ERAP1_C 618..945 CDD:463368 85/353 (24%)
Blue background indicates that the domain is not in the aligned region.

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