DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42335 and Enpep

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_031960.1	Gene:	Enpep / 13809	MGIID:	106645	Length:	945	Species:	Mus musculus

Alignment Length:	949	Identity:	237/949 - (24%)
Similarity:	411/949 - (43%)	Gaps:	164/949 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDA 88
            ::||...:.|.||:|.:..|   :|...:.|.|:|::.:  :...:.:.||.....||:  |.:.
Mouse    82 NFRLPDFINPVHYDLEVKAL---MEEDRYTGIVTISVNL--SKPTRDLWLHIRETKITK--LPEL 139

  Fly    89 AGAQVEAIDISRLIYEAATQQVRVPLTE--AAQPGKN-YTLGFKYTGHIRTDMAGFFSASYVERD 150
            .....|.:.|.|.......:.|.:...|  ||..|.: |.|..::.|.:...:.||:..:|:| |
Mouse   140 RRPSGEQVPIRRCFEYKKQEYVVIQAAEDLAATSGDSVYRLTMEFKGWLNGSLVGFYKTTYME-D 203

  Fly   151 TNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDH 215
            ..: |.:|.|..:..:||...||||||..|:.:.:.|:.|..|.:::|  :.|.|:...|   |:
Mouse   204 GQI-RSIAATDHEPTDARKSFPCFDEPNKKSTYSISIIHPKEYSALSN--MPEEKSEMVD---DN 262

  Fly   216 FKETPV-----MSTYLLAFMVANYSARGNESE----FAVLTRPEFYDNTEFSYHVGQQVVSAYGE 271
            :|:|..     |||||:.|.|..::|...:|.    ..|..:|...:..|::.::.|.|...:.:
Mouse   263 WKKTTFVKSVPMSTYLVCFAVHRFTAIERKSRSGKPLKVYVQPNQKETAEYAANITQAVFDYFED 327

  Fly   272 LFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETS 336
            .|...||   ...|...:.|.|....||||||:.|.:..|:.:|..|.. |:::....::|||..
Mouse   328 YFAMEYA---LPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSAS-SNQQRVASVVAHELV 388

  Fly   337 HMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMT 401
            |.|||::||..||...||||.||.::|:...:....|:.:..|.::..:..:...|:...:.|:.
Mouse   389 HQWFGNTVTMDWWDDLWLNEGFASFFEFLGVNHAEKDWQMLSQVLLEDVFPVQEDDSLMSSHPVV 453

  Fly   402 SPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHL 466
               ..:.||::|...|.||:|:|||.|:||.::.:..|.|....:.||:::...|.       ..
Mouse   454 ---VTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLKKFQFANA-------KT 508

  Fly   467 FEHWPKNQD---VDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLL-NKDDGSN--ATLK 525
            .:.|...|:   :.:.:.:..:|.|:|||::.|...|     .:.|.|||| :|.|.|.  :.|.
Mouse   509 SDFWDSLQEASNLPVKEVMDTWTSQMGYPVVTVSGRQ-----NITQKRFLLDSKADPSQPPSELG 568

  Fly   526 YT--VPITFTTNLERDFYNLTPYKYLHK---TVNVLWLDFTSPIDWILFNLRQSNYQRVFYD--- 582
            ||  :|:.:..|   |...:|.|..|.|   |:|.    ..|...::..|.....:.||.|:
Mouse   569 YTWNIPVRWADN---DNSRITVYNRLDKGGITLNA----NLSGDAFLKINPDHIGFYRVNYEGGT 626

  Fly   583 -DTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAV 646
             |.:.|.|     ::||:.....:|:..|||.|..|:||.::|........||..|.:::||..|
Mouse   627 WDWIAEAL-----SSNHTRFSAADRSSFIDDAFALARAQLLNYKIALNLTMYLKSEEDFLPWERV 686

  Fly   647 YENLNTVAKRLTP--EQLPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVAN--RNKLIKWLCR-- 705
            ..:::.:......  |..|....|.......|.:.|  ||  |||...:..  |..::.:.|:
Mouse   687 ISSVSYIISMFEDDRELYPMIETYFQGQVKPVADLL--GW--QDTGSHITKLLRASILGFACKMG 747

  Fly   706 --------------YQASNCRPKVNVQFVTGHEVPSPDYRETFYCAASGADYNSYTMLWGQYYLE 756
                          :...:....||::.:.        ||.....:.:.|.:| ||:  .||...
Mouse   748 DREALGNASQLFDSWLKGSASIPVNLRLLV--------YRYGMQNSGNEAAWN-YTL--EQYQKT 801

  Fly   757 NRTSEKNMLWAAISCTRDYETHYHKMIISGTESVEQKKIGIARMYE--ENPDLV--QAIFEMITE 817
            :...||..|                  :.|..||:..|: :||..|  ::|:::  |.:|.:
Mouse   802 SLAQEKEKL------------------LYGLASVKDVKL-LARYLEMLKDPNIIKTQDVFTV--- 844

  Fly   818 NIMELAYNFQSWSDTAE---------------VIND--------MAEYFTTREQQQLLKEFY--Y 857
             |..::||  |:..|..               .|||        :||.|.|..|...::.|:  |
Mouse   845 -IRYISYN--SYGKTMAWNWIQLNWDYLVSRFTINDRYLGRIVTIAEPFNTELQLWQMQSFFAKY 906

  Fly   858 SNHQFFGESEELLSKSLVTVEKNLNWAETHLEGLVKYLA 896
            .|   .|...:...:.|.||:.|:.|...:.:.:.::.|
Mouse   907 PN---AGAGAKPREQVLETVKNNIEWLNVNRQSIREWFA 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	114/410 (28%)
		M1_APN_2	34..492	CDD:189008	127/472 (27%)
		ERAP1_C	567..874	CDD:288671	76/359 (21%)
Enpep	NP_031960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..77
		Peptidase_M1	84..474	CDD:279741	114/410 (28%)
		M1_APN_2	92..537	CDD:189008	127/472 (27%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		1/3 (33%)
		ERAP1_C	608..922	CDD:288671	77/361 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010