DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42335 and rnpepl1

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001335117.1	Gene:	rnpepl1 / 100535895	ZFINID:	ZDB-GENE-030131-5522	Length:	692	Species:	Danio rerio

Alignment Length:	703	Identity:	156/703 - (22%)
Similarity:	263/703 - (37%)	Gaps:	178/703 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSSIFRAFWLLCSLLICVTNAADYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTL 66
            |:|.|..|.|....|....|.|..|:.|..|     |.:..::..|:..|.|...|
Zfish    39 SASNFHCFKLRHFHLDLHLNFAVKRITGWQV-----LELTPVQPGVQSLILDTHPS--------- 89

  Fly    67 EVQQIILHADTLDITECWLLDAAGAQVEAIDISRLIYEAATQQVRVPLTE------------AAQ 119
                :::|:     .:|.:..|:||..        ::.:.|.:|. |.|:            ..:
Zfish    90 ----LLIHS-----VDCKVPGASGAPD--------VFLSLTYRVE-PFTDYGSSLNITLPAAVIR 136

  Fly   120 PGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQ 184
            |.:.:.:..:||   .||....:... .|.....||.|..||...:..|...||||.||:|:.:.
Zfish   137 PHRAFRVTVRYT---TTDGPAIWWLD-AELTCGQTRPLVFTQGHSVCNRSFFPCFDTPAVKSTYS 197

  Fly   185 LQIVRPNGYQSIANTKLKETKALSQDRFVDHFKETPVMSTYLLAFMV-----ANYSARGNE-SEF 243
            ..:..|.|...:.:.  ..:....|||......|.|| ..||:|.:.     |:...|... :|.
Zfish   198 ATVRVPEGVTVLMSA--SRSAYSKQDRVFQFSMEYPV-PAYLVALVAGDLQHADIGPRSRVWAEP 259

  Fly   244 AVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSD 308
            .:||...    ::....|.:.:..|.| || .||.....|::  ...|.||...|||..|.....
Zfish   260 CILTCAV----SKLGGSVERWLNVAEG-LF-GPYVWGRYDLV--FLPPSFPIVAMENPCLTFIIS 316

  Fly   309 DVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPD 373
            .:|          ..:||.:..:.||.:|.|||::||.:.|...||:|..|.|.:..:..:.|.:
Zfish   317 SIL----------ESQEFLLIDVIHEIAHGWFGNAVTNATWEEMWLSEGLATYAQRRITTEAYGE 371

  Fly   374 --------YHLDEQFVVRQMQLIFGTDAQNGTQPMTSPESEIQ---TPSQIAYKFSGIAYAKGAC 427
                    :.||.  :.|||:|:      ....|::..:::.:   .||.:...|:   |.||.|
Zfish   372 AFTCLETVFRLDA--LHRQMRLL------GDNNPVSKLQAKFEPGVNPSSLMNLFT---YEKGFC 425

  Fly   428 IVRMWRNLMG-AENFDTAIRSYLQQYHLTNTVPYNLFYHLFEHWPKNQDVDLVDFLTDYTEQVGY 491
            .|.....|.| .:.||:.:|:|::::..::.:..                ||:||...:     :
Zfish   426 FVSYLSQLCGDIKRFDSFLRAYIEKFRFSSVIAQ----------------DLLDFFLGF-----F 469

  Fly   492 PMI---IVKALQGNKVVTVEQSRF-------LLNKDDGSNATLKYTVPITFTTNLERDFYNLTPY 546
            |.:   .|...:|     :|..|:       |...|..:..||  |.|:....:|   :.|..|
Zfish   470 PELKEGCVAQREG-----LEFERWLNGCGPPLCEPDLSAGRTL--TGPVQHLCDL---WGNDAP- 523

  Fly   547 KYLHKTVNVLWLDFTSPIDWILFNLRQSNYQRVFYDDTL-------REGLLLAISATNHSGIPVE 604
                .|..:...|.:|   |       |.:|.|.:.|.|       :|.:.|..|.
Zfish   524 ----DTQVISTFDLSS---W-------STFQTVLFLDRLLDRSPLSQEVMSLLSSC--------- 565

  Fly   605 NRAQIIDDLFNFAQAQYVD-------YADVFRFLEYLAKEVEYVPWYAVYENL 650
             .|.::||:....|.:::.       |.|:.|...:|.|....:....:||:|
Zfish   566 -YAALLDDMNAEVQIRWLQIVVRNSFYPDLPRVRSFLHKHTSRMYTVPLYEDL 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	96/427 (22%)
		M1_APN_2	34..492	CDD:189008	107/487 (22%)
		ERAP1_C	567..874	CDD:288671	20/98 (20%)
rnpepl1	NP_001335117.1	M1_LTA4H	36..490	CDD:189006	123/544 (23%)
rnpepl1	NP_001335117.1	Leuk-A4-hydro_C	507..649	CDD:312599	30/141 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910