Protein Alignment CG42335 and erap1

DIOPT Version :10

• Sequence 1: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_002933475.2
• Gene: erap1 / 100496768
• XenbaseID: XB-GENE-983344
• Length: 932
• Species: Xenopus tropicalis
• Alignment Length: 920
• Identity: 240/920 - (26%)
• Similarity: 414/920 - (45%)
• Gaps: 86/920 - (9%)

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDAAG 90
            ||.....|.||:|   ::..::....|.|...:|:.|  |.:...::||:..|:||:..:....|
 Frog    52 RLPTFAAPLHYDL---LIHPNLTTLTFSGLTKVTVTV--TQKTSFLVLHSKHLEITKTTIKRKLG 111

  Fly    91 AQVEAIDISRLIYE-AATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDTNVT 154
            ......|:  |:.| ...:|:.:...:...||:|||:..:|..::..:..||:.::|..:|..|
 Frog   112 KDPVLQDL--LLREHPVNEQIALLAADPLIPGENYTIYIEYNANLSKNFRGFYKSTYKTKDGEV- 173

  Fly   155 RWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDHFKET 219
            |.||.||.:...||...|||||||.||.|.:||.|...:.:::|..:.:|..:......|||..:
 Frog   174 RVLASTQFEPTAARTAFPCFDEPAFKASFSIQIRREPKHHAVSNMPVVKTVNIGGGLLEDHFAAS 238

  Fly   220 PVMSTYLLAFMVANYSA----RGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQSPYAEL 280
            ..|||||:||:|:::.:    ..:....:|...||..|..|::.....:::..|.:.|...|...
 Frog   239 VKMSTYLVAFIVSDFKSISQVTNHGVRISVYATPEKIDQAEYALKAAVKLLDFYEDYFNISYPLP 303

  Fly   281 GNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDSVT 345
            ..|:   |:.|.|....||||||..|.:..|:.:|..|.. |.|.:...|||||.:|.|||:.||
 Frog   304 KQDL---AAIPDFQSGAMENWGLTTYRESALLHDPKTSTA-SHKLWVTMIIAHELAHQWFGNLVT 364

  Fly   346 FSWWSYFWLNEAFARYYEYFMAHQLYP-----DYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPES 405
            ..||:..||||.||::.||......||     ||.||:.|  |.|.:    |:.|.:..:::|
 Frog   365 MEWWNDLWLNEGFAKFMEYVSVRVTYPELQVEDYFLDKCF--RAMDV----DSLNSSHAVSTP-- 421

  Fly   406 EIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFE-- 468
             ::.|.:|...|..::|.|||||:.|..:.||||:|:..|..||::|...|....:|:..:.:
 Frog   422 -VENPEEIQEMFDEVSYDKGACILNMLMDYMGAESFEAGIVDYLRRYSYRNARNEDLWNSMTDVC 485

  Fly   469 -----------------HWPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNK 516
                             ||.:.:.:|:...:..:|.|.|:|::.| .::| |.|.:.|..:|...
 Frog   486 PSDETNSGYCTKTRQTSHWSEGEIIDVKSMMNTWTLQKGFPLVTV-TVKG-KYVYLHQEHYLKGS 548

  Fly   517 DDGSNATLKYTVPITFTTNLERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILFNLRQSNYQRVFY 581
            .|...:.|.:.:|:|:.|:...   .:..:..:.|| :||.|  ...::||.||:..:.|..|.|
 Frog   549 TDTEASGLLWHIPLTYITSKSN---TVQRFLLMSKT-DVLVL--AEEVEWIKFNVGMNGYYIVHY 607

  Fly   582 DDTLREG--LLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWY 644
            :.   ||  .|:.:...||:.|...:||.:|:..|.......:..........||..|.:.:|.:
 Frog   608 EG---EGWDALIKLLQENHTAISSNDRANLINSAFQLVSIGRLPIDKALSLSLYLKNEDKIMPVF 669

  Fly   645 AVYENLNTVAKRLTPEQLPDFRIYLSSITAAVFEKL--GVGWNAQDTPLDVANRNKLIKWLCRYQ 707
            ...:.|..:.|.:....:.:....:......:..||  ...|..:.:..:...|:.|:.:.|..|
 Frog   670 QGMDELIPIYKLMEKRDMQEVESQMKKYILNLLRKLIDAQSWTDEGSVSERMLRSSLLLFACVRQ 734

  Fly   708 ASNCRPKVNVQFVTGHE----VPSP-DYRETFYCAASGADY-NSYTMLWGQYYLENRTSEKNMLW 766
            ...|..:....|....|    :..| |.....|  |.||.. ..:..|:.:|......||||.:.
 Frog   735 YQPCVQRAEQYFKRWQESNGTISLPRDVASAVY--AVGAQTPEGWDFLFEKYKTTLSGSEKNQIE 797

  Fly   767 AAISCTRDYETHYHKMI------ISGTESVEQKKIGIARMYEENPDLVQAIFEMITENIMELAYN 825
            .|::.|    :..||:.      :.|.....|....|......||......:|.:..|...|...
 Frog   798 LALAIT----SLKHKLQWLMEEGMKGDHVRTQDLPHIVLYVSRNPVGYPLSWEFLKNNWGNLVQK 858

  Fly   826 FQSWSDT-AEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSLVTVEKNLNWAETHLE 889
            |:..|.| .:::..:.:.::|:|..:.:..|:.|..: .|.....:.::..|:|:|:.|.:.:|:
 Frog   859 FELGSRTVGDMVVGITKQYSTKEWLEEVTGFFDSLKE-MGSQLRCVQQARETIEENIRWMDKNLD 922

  Fly   890 GLVKYLADRN 899
             |||...:.|
 Frog   923 -LVKSWLENN 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	M1_APN-Q_like	34..487	CDD:341064	143/481 (30%)
		ERAP1_C	566..878	CDD:463368	66/328 (20%)
erap1	XP_002933475.2	M1_APN-Q_like	60..521	CDD:341064	143/481 (30%)
		ERAP1_C	592..911	CDD:463368	66/328 (20%)