DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and enpep

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_002934295.1	Gene:	enpep / 100494326	XenbaseID:	XB-GENE-977050	Length:	965	Species:	Xenopus tropicalis

Alignment Length:	925	Identity:	242/925 - (26%)
Similarity:	402/925 - (43%)	Gaps:	112/925 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLDA 88
            ::||...:.|.|||:.   |...:|...::|.|||.||:..|  .:.:.||.....|.....|..
Frog    97 EFRLPTYINPVHYNVE---LHPVMEQDTYNGTVSIWLRLSKT--SKHLWLHLRETKIIGQLTLTR 156

  Fly    89 AGAQV------EAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYV 147
            ...|:      :.|....|:.||  |||..| .........|.|..::.|.:...:.||:..:|
Frog   157 GSQQIPIQQCFQYIPNEYLVLEA--QQVLDP-NSPTDENDTYCLTLQFAGRLDGSLVGFYRTTY- 217

  Fly   148 ERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRF 212
             ::..||:.:|....:..:||...||||||..||.:.:.|:....|.:|:|..::|:.||.....
Frog   218 -QENGVTKSIAAADHEPTDARKSFPCFDEPNKKATYTISIIHREEYDAISNMPVQESVALGNGWK 281

  Fly   213 VDHFKETPVMSTYLLAFMVANY------SARGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGE 271
            ...|:::..|||||:.|.|..:      |.||  ....:..:|......|::.:..:.|...:.|
Frog   282 RTLFEKSVPMSTYLVCFAVHQFKYVERLSKRG--VPLRIYVQPLQNATAEYAANTTKIVFDFFEE 344

  Fly   272 LFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETS 336
            .|..||:   ...|...:.|.|....|||||||.|.:..|:.:|..|.. .:|:....:||||..
Frog   345 YFNMPYS---LPKLDQIAIPDFGTGAMENWGLITYRETNLLYDPNESAT-VNKQRVAAVIAHELV 405

  Fly   337 HMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMT 401
            |.|||:.||..||...||||.||.::||.......|.:::.:|.::..:..:...||...:.|:.
Frog   406 HQWFGNIVTMDWWDDLWLNEGFASFFEYSGVDAAEPLWNMLDQILIDDLLPVMRDDALLSSHPII 470

  Fly   402 SPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHL 466
               ..:.||::|...|..|:|.|||.|:||..:.:..|||....:.||:.|...|....:.:..|
Frog   471 ---VTVSTPAEITSVFDAISYNKGASILRMLEDWISPENFKKGCQDYLKDYVFKNAKTDDFWNSL 532

  Fly   467 FEHWPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNA-------TL 524
                .|.....:.:.:..:|.|:|||::.|::|.     ||:|:||||  |..:||       ..
Frog   533 ----AKASGKPVKEVMDTWTRQMGYPVLNVESLN-----TVKQTRFLL--DPNANALEPPSEFNY 586

  Fly   525 KYTVPITF-TTNLERDF---YN--------LTPYKYLHKTVNVLWLDFTSPIDWILFNLRQSNYQ 577
            .:.:|:|| .||...|:   ||        |||:.           |.|.  .::..|.|...:.
Frog   587 MWNIPVTFYATNNSVDYNLLYNKSIPAGLSLTPFN-----------DATD--GFLKINTRHLGFF 638

  Fly   578 RVFYD-DTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYV 641
            ||.|: .|..:  |.|:...||......:||.:|||.|..|:|:.:||.......:||.||..|:
Frog   639 RVNYELSTWNQ--LSALLEANHETFTDADRAGLIDDAFALARAEKLDYNISLDITKYLEKETNYL 701

  Fly   642 PWYAVYENLNTVAKRLTPEQ--LPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVANRNKLIKWLC 704
            .|.....:|..::..|..:.  .|.|:.||......:.:|  .||....:.:|...|..::...|
Frog   702 TWTRAISSLAYLSDMLEDDNTIYPKFQEYLRKQVKPITQK--HGWEDTGSDIDKLLRASVLALSC 764

  Fly   705 RY---QASNCRPKVNVQFVTGHEVPSPDYRETFY---CAASGADYNSYTMLWGQYYLENRTSEKN 763
            :.   .|.|...::...::.|..:| .:.|:..|   ...|| :..|:..::.||...:...||.
Frog   765 KMGDPDALNEASRLFRDWIGGKSIP-VNLRQLVYRYGMQQSG-NQESWNYMFQQYLTTSLAQEKE 827

  Fly   764 MLWAAISCTRDYE--THYHKMIISGTESVEQKK-------IGIARMYEENP--DLVQAIFEMITE 817
            .|...::...:.|  ..|.|:|.: |..::.:.       |.:...|.:..  |.|:..::.:.:
Frog   828 KLLQGLASANNIELIDRYLKLIYN-TSLIKSQDALNVIYYISVYSQYGKQMAWDWVRINWDYLVD 891

  Fly   818 NIMELAYNFQSWSDTAEVINDMAEYFTTREQQQLLKEFY--YSNHQFFGESEELLSKSLVTVEKN 880
            .     ||... .:...::..::..|.|..|...::.|:  |.|   .|..|....::|.||..|
Frog   892 R-----YNIND-RNLGRIVTRISGTFNTATQLWQMENFFEKYPN---AGAGEIPRKQALETVRNN 947

  Fly   881 LNWAETHLEGLVKYL 895
            :.|...:.||:..:|
Frog   948 IEWVAANKEGIKSWL 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	118/410 (29%)
		M1_APN_2	34..492	CDD:189008	133/469 (28%)
		ERAP1_C	567..874	CDD:288671	71/328 (22%)
enpep	XP_002934295.1	M1_APN-Q_like	107..549	CDD:341064	130/464 (28%)
enpep	XP_002934295.1	ERAP1_C	627..946	CDD:378732	74/334 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920