DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42335 and anpep

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_031755081.1	Gene:	anpep / 100492262	XenbaseID:	XB-GENE-981369	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	942	Identity:	264/942 - (28%)
Similarity:	441/942 - (46%)	Gaps:	120/942 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YRLEGSVVPSHYNLTIG--VLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITECWLLD 87
            |||..::.|.||::.:.  :::|:....:|.|:  .|...:.......||:|::.|:.|:....|
Frog    83 YRLPKTLSPVHYDVELQPFLVKNADGLYVFRGK--STAFFICNDATDLIIIHSNKLNHTKFNSFD 145

  Fly    88 AA---GAQVEAI-------DISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFF 142
            |.   ||...|:       |...|:.:||...|         |||.|.|..::.|.:..|:|||:
Frog   146 AKLQDGATDVALKSTFFQKDKQFLVVQAAANLV---------PGKQYGLYTEFVGELADDLAGFY 201

  Fly   143 SASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKAL 207
            .:.|:|  ..||:.:|.||||..:||...|||||||:||.|.:.:.....|::::|.:..:...:
Frog   202 RSEYLE--DGVTKIIATTQMQAPDARKAFPCFDEPAMKATFNITLKYRQPYKAMSNMREIDRSTV 264

  Fly   208 SQDR---FVDHFKETPVMSTYLLAFMVANYSARGNESEFAVLTRPEFY---------DNTEFSYH 260
            ::|.   .|..|.:||.||:||:||:|:.:.|.|:... |.:|..:.:         :..|::..
Frog   265 TEDGQQWTVSKFDKTPKMSSYLVAFIVSEFEAVGDPGN-ATVTGVQIWGRKKAIQDENQGEYALS 328

  Fly   261 VGQQVVSAYGELFQSPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWS--- 322
            |.:.::..:.|.:::||....:|   ..:.|.|....||||||:.|.:..|:    :.|..|
Frog   329 VTKPILDFFAEYYRTPYPLPKSD---QVALPDFSAGAMENWGLVTYRETALL----FDDQVSSIG 386

  Fly   323 DKEFAIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQL 387
            :||..:.:||||.:|.|||:.||..||:..||||.||.|.||..|.:..|::::.:..|:..:..
Frog   387 NKERVVTVIAHELAHQWFGNLVTIRWWNDLWLNEGFASYVEYLGADKAEPNWNIKDLIVLNDVHR 451

  Fly   388 IFGTDAQNGTQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQY 452
            :...||...:.|:||.|.|:.:||:|:..|..|||:|||.::||....:....|...:.|||:.:
Frog   452 VMAVDALASSHPLTSREDEVNSPSEISALFDSIAYSKGASVIRMLSEFLTEPLFVDGLASYLKGF 516

  Fly   453 HLTNTVPYNLFYHLFEHWPKNQD------VDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSR 511
            ..:|||..:|:.||  .|..|..      :.:.|.:..:..|:|:|::.:....|  |||  |..
Frog   517 EYSNTVYSDLWTHL--QWAVNNQTAVKLPLPIKDIMDTWVLQMGFPVVKIDTATG--VVT--QKH 575

  Fly   512 FLLNKDD----GSNATLKYTVPITFTTNLERDFYNLTPYKYLHKTVNVLWLDFTSPI-------- 564
            |||:.|.    .|....|:.|||:              ||...|..|: ||...|..
Frog   576 FLLDPDSVVTRPSPFDYKWKVPIS--------------YKISSKEDNI-WLQNESETVEDFKITG 625

  Fly   565 -DWILFNLRQSNYQRVFYDDTLREGLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVF 628
             ||:|.||..:.|.||.|||.....||..:. |:|..|||.||||||||.||.|:|:.:......
Frog   626 NDWLLVNLNVTGYYRVNYDDNNWSRLLNQLQ-TSHQAIPVINRAQIIDDAFNLARAKQITTIQAL 689

  Fly   629 RFLEYLAKEVEYVPWYAVYENLNTVAKRL-TPEQLPDFRIYLSSITAAVFE--KLGVGWNAQDTP 690
            ...:|::.:.||:||.|....|:...:.. ..|.....:.|:......:||  |...| |..:.|
Frog   690 DTTKYISADREYMPWQAALSGLSYFTQMFDRTEVFGPMKKYMKMQVNPLFEYFKQETG-NWTNRP 753

  Fly   691 LDVANRNKLIKWL---CRYQASNCRPKVNVQFVTGHEVPS-----PDYRETFYC--AASGADYNS 745
            :.:.::...|..|   |.|...:|....:..|......|.     |:.|...||  .|.|.: ..
Frog   754 VSLTDQYCEINTLSTACSYDIEDCLKFASELFSQWMATPQQNNIHPNLRTNVYCTAVAQGGE-QE 817

  Fly   746 YTMLWGQYYLENRTSEKNMLWAAISCTRD--YETHYHKMIISGTESVEQKKIGIARMYEENP--- 805
            :..:|.::.|.:...|::.|.||::|:::  ....:.:..:..|....|..:........||
Frog   818 WNFVWDRFQLTDIAQEQDKLRAALACSKEPWILNRFLEYSLDPTMIRRQDAVSTISSVVNNPIGQ 882

  Fly   806 ----DLVQAIFEMITENIMELAYNFQSWSDTAEVINDMAEYFTTR-EQQQLLKEFYYSNHQFFGE 865
                |.|:|.::.:.....|.:::|      ..:|..:...|:|. |.||||:....:.:..||.
Frog   883 SLAWDFVRAKWKTLYSMFGESSFSF------GNLIERVTRRFSTEFELQQLLQFKADNQNPGFGT 941

  Fly   866 SEELLSKSLVTVEKNLNWAETHLEGLVKYLAD 897
            :.:.|.:::...:.|:||...:...:.|:..|
Frog   942 ASQALEQAIEKTKANINWVNQNKAAVKKWFED 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	131/425 (31%)
		M1_APN_2	34..492	CDD:189008	148/490 (30%)
		ERAP1_C	567..874	CDD:288671	83/329 (25%)
anpep	XP_031755081.1	M1_APN-Q_like	92..555	CDD:341064	146/485 (30%)
anpep	XP_031755081.1	ERAP1_C	628..955	CDD:403137	84/335 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110