DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42335 and erap2

DIOPT Version :9

Sequence 1:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_005165525.1	Gene:	erap2 / 100144556	ZFINID:	ZDB-GENE-080402-6	Length:	935	Species:	Danio rerio

Alignment Length:	948	Identity:	249/948 - (26%)
Similarity:	427/948 - (45%)	Gaps:	133/948 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLEGSVVPSHYNLTIGVLRNSVEPTI----FDGEVSITLRVVGTLEVQQIILHADTLDITECWLL 86
            ||...:||.||:|.|       .|.:    |.|.|.|.:.|..  ....::||:..|.|....:|
Zfish    44 RLPNYIVPVHYHLLI-------HPNLTTLSFTGSVKIEIDVKN--NTNWVVLHSKNLKIYTATVL 99

  Fly    87 DAAGAQVEAIDISRLIYEAATQQVRVPLTEAAQPGKNYTLGFKYTGHIRTDMAGFFSASYVERDT 151
            |...|.:....:|.|.| ...:|:.:...:....|:.|.|..::...:.....||:.::| ...:
Zfish   100 DEHEAHLSEKTLSVLEY-PLHEQIAIFSPKILTSGEKYFLYLEFGAPLSDGFHGFYKSTY-RTKS 162

  Fly   152 NVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFVDHF 216
            ..||.||.|..:..:||:.|||||||..||.:.::|.|...:.:::|..|::|..:|...|.|||
Zfish   163 GETRVLASTHFEPTSARMALPCFDEPVFKANYTVRIRRGPSHIALSNMPLEQTVEISNGLFEDHF 227

  Fly   217 KETPVMSTYLLAFMVANY------SARG-NESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQ 274
            :.:..||:|||||::.::      :|.| |.|.:||   ||.:..|:::.....:::..|.:.|.
Zfish   228 EASVKMSSYLLAFIICDFKSVSGLTATGINISIYAV---PEKWHQTQYALEAALRLLEFYEQYFN 289

  Fly   275 SPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMW 339
            ..|.....|::   :.|.|....||||||..|.:..|:.:|..|.. |||.:...:|.||.:|.|
Zfish   290 ILYPLPKLDLI---AIPDFESGAMENWGLTTYRETSLLYDPDISSA-SDKLWVTMVIGHELAHQW 350

  Fly   340 FGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPE 404
            ||:.||..||:..||||.||||.|......:||:..:::.|:......| |.|:.|.::|::
Zfish   351 FGNLVTMDWWNDIWLNEGFARYMESVSVEAVYPELKVEDHFLDTCFGAI-GRDSLNSSRPIS--- 411

  Fly   405 SEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFE- 468
            |..::|:||...|..::|.|||||:.|.|:.:..|.|.:.|..||:::...|....:|:..|.:
Zfish   412 SLAESPTQIKEMFDTVSYEKGACILHMLRHFLTDEGFQSGIIRYLRRFSYCNARNEDLWDSLIKT 476

  Fly   469 ----------------HWPKN------QDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSR 511
                            ...||      :.|||...:..:|.|.|.|::.||. ||.| :.:.|.|
Zfish   477 CSEEDFAAGEYCYSSAQATKNAYRFAGEHVDLKKMMNTWTLQKGIPLVTVKR-QGRK-LHIGQER 539

  Fly   512 FL--LNKDDGSNATLK----YTVPITF-TTNLERDFYNLTPYKYLHKTVNVLWLDFTSPIDWILF 569
            ||  :..||.|..:|:    :.:|:|: |::.:.:..::     |.|..:||.||  ..:||:..
Zfish   540 FLKIVLPDDPSWHSLQDGYLWHIPLTYKTSHSDHEVKHI-----LDKKSDVLLLD--EHVDWVKL 597

  Fly   570 NLRQSNYQRVFYDDTLREG--LLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLE 632
            |...:.|..|.||:   ||  .|..:...||:.:..::||.:|.:.|....|..:........:.
Zfish   598 NTDMNGYYIVHYDE---EGWNALTELLKVNHTALSFKDRASLIHNAFQLVTAGRLSLDRALDLIA 659

  Fly   633 YLAKEVEYVPWYAVYENLNTVAKRLTPEQLPD----FRIYLSSITAAVFEKLGVGWNAQDTPLDV 693
            ||..|...||.......|.:..|.:...::.|    .:.|:......|.:|  ..|:......|.
Zfish   660 YLKSETHNVPLLQGLGYLQSFYKLIEKRKIADVTHNLKTYILQYFKDVIDK--QSWSDDGMVSDR 722

  Fly   694 ANRNKLIKWLCRYQASNCRPKVNVQFVTGHE------VPSPDYRETFYCAASGADYNSYTMLWGQ 752
            ..|..::...|......|..|....||:..:      :|: |..||.|...: .|.:.:..|..|
Zfish   723 RLREDVLSLACDLDYPPCLEKAERLFVSWVKSNGTISLPT-DVSETVYMVGA-QDDSGWVYLLRQ 785

  Fly   753 YYLENRTSEKNMLWAAISCTRDYETHYHKMIISGTESVEQKKIGIARMYEENPDLVQAIFEMITE 817
            |.:....:||:...:|::.::|.| ...:::..|.|       |.....:..|.|:.    |:..
Zfish   786 YGVSMCETEKSKFLSALTSSKDSE-KLSRLLQLGME-------GTVIKTQNLPSLIY----MVAR 838

  Fly   818 NIME--LAYNF--QSWSDTAE------------VINDMAEYFTTREQQQLLKEFYYSNHQFFGES 866
            |.:.  ||::|  :.|::..|            ::..:.::.:|.|.:::        ..||...
Zfish   839 NPVGHFLAWDFVKKHWNELVEKFPLGSFGIREIIVGTVTQFSSTEELREV--------ESFFKSI 895

  Fly   867 EELLSKSLV------TVEKNLNWAETHLEGLVKYLADR 898
            :|.:|:..:      .||||:.|.:.:||.:..:|..|
Zfish   896 QEQVSQLRIIQVATENVEKNIVWLKRNLETMRTWLQRR 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	126/409 (31%)
		M1_APN_2	34..492	CDD:189008	145/491 (30%)
		ERAP1_C	567..874	CDD:288671	66/334 (20%)
erap2	XP_005165525.1	Peptidase_M1	44..432	CDD:279741	126/409 (31%)
		M1_APN_2	52..522	CDD:189008	145/491 (30%)
		ERAP1_C	595..911	CDD:288671	66/342 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12102
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020