Protein Alignment CG31233 and ERAP2

DIOPT Version :10

• Sequence 1: NP_732653.2
• Gene: CG31233 / 42557
• FlyBaseID: FBgn0051233
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_071745.1
• Gene: ERAP2 / 64167
• HGNCID: 29499
• Length: 960
• Species: Homo sapiens
• Alignment Length: 983
• Identity: 285/983 - (28%)
• Similarity: 456/983 - (46%)
• Gaps: 137/983 - (13%)

  Fly    23 QAAVVRQYPILDHLQHLENPMQRLVVPLADE------DNYRLPYDTIPSHYAVSLSTNVHTGDTV 81
            |..:..|:.:.......|:|.   ..|:|..      ...|||...||.||.:.:..|:.:.|.|
Human    31 QICICSQFSVPSSYHFTEDPG---AFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFV 92

  Fly    82 FNGTVAITLSVLNTTTKIVVHARQLENFTASIIQQGVTEAV--AQEL-VYEYEAEREFLTFSKTG 143
            .:..:.:.:|  |.|..|::|::.||...|::..:..:..:  .:|| |..|.|..:.      .
Human    93 ASEKIEVLVS--NATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQI------A 149

  Fly   144 LTFPEDTT----WILTINYQGHLRTDNGGFYLSTYTDEEGNTKYLATTQFESTDARHAFPCYDEP 204
            |..||..|    :.:.:::|..|.....|||.|||....|.|:.||.|.||.|.||.||||:|||
Human   150 LLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEP 214

  Fly   205 SKRAEFTITIKHDPSYNAISNMP-VDSSSTSGVTV---FQKTVNMPSYLVAFIVSEFVFSEG-EL 264
            ..:|.|:|.|:.:..:.|:|||| |.:....|..:   |:.||.|.:||||:||.:|....| ..
Human   215 LFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTS 279

  Fly   265 NGLPQRVFSRNGTEHEQEWALTTGMLVEKRLSGYFDVPFALPKLDQAGIPDFAAGAMENWGLATY 329
            :|:...:::.....::..:||...:.:......|||:.:.|.|||...|||||.||||||||.||
Human   280 SGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITY 344

  Fly   330 REEYLLYNTENSTTSTQTNIATIEAHEDAHMWFGDLVAIEWWSFLWLKEGFATLFENLAVDLAYP 394
            ||..||::.:.|:.|.:..:..:.|||.||.|||:||.:|||:.:|||||||...|.:||:..||
Human   345 RETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYP 409

  Fly   395 EWDIFQTFHAGSYQSALVNDASANARPMSHFVQKPSEIALLYDSVSYAKAGSVLDMWRHALTNTV 459
            |.. |..:........:..|:..::||:|...:.|::|..::|.|||.|...:|:|.:..|....
Human   410 ELQ-FDDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEK 473

  Fly   460 FQRGLHNYLVDNQFTAANPSKLFEAIAKAAVE------------------------ENYEVKATV 500
            ||:|:..||....:..|....|:.:::.:.:|                        ||.|||
Human   474 FQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVK--- 535

  Fly   501 PDMMGSWTNQGGVPLLTVTRNYDNGSFTVK-----QSVYTNDKDY---TNDKLWYVPINYAESKN 557
             :||.:||.|.|:|||.|.:  |..|..::     |.|:..|.::   ....||::|:.|:.|.:
Human   536 -EMMTTWTLQKGIPLLVVKQ--DGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSS 597

  Fly   558 PDFRNTEATHYLLNQSEITIYSDL-DQTNWLILNKKSTGYYRVLYDAQNY-QLITSALITRPHK- 619
                |....|.|.::::..   || ::|:|:..|..|.|||.|.|:...: ||||.  :.:.|.
Human   598 ----NVIHRHILKSKTDTL---DLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQ--LNQNHTL 653

  Fly   620 IDPRNRAQLINDLYRFATSGR------------VPHAT----LLELLTYLPQEDQYSPWSATN-- 666
            :.|::|..||:|:::...:||            :.|.|    |||.|:||  |..|......|
Human   654 LRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYL--ESFYHMMDRRNIS 716

  Fly   667 TVITLLNRYLSGDADYGNFQFYVRELVSLQ--FDKFGVNDNKGDHHLVPFTRNVLINLACLAGLE 729
            .:...|.|||..         |.:.::..|  .||..|.|.        ..|:.|:.|||.....
Human   717 DISENLKRYLLQ---------YFKPVIDRQSWSDKGSVWDR--------MLRSALLKLACDLNHA 764

  Fly   730 NCLTETTAKLTALVEEGTK--IEPNLQSQVYCNGLKQADDKTFDFVFNKLLNSTDQAERRLLISA 792
            .|:.:.....:..:|...|  |..::...||..|.:..  ..::::..:...|...||:..::.|
Human   765 PCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTT--AGWNYLLEQYELSMSSAEQNKILYA 827

  Fly   793 LGCSQNTAQLEKFVYSSIEPEGLRDQERITVLSPVYSRGEVGLLVAIEFLQKNWE---KYGQLNS 854
            |..|::..:|.|.:...:|.:.::.|....:|..: :|...|..:|.:|:::||.   |...|.|
Human   828 LSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAI-ARRPKGQQLAWDFVRENWTHLLKKFDLGS 891

  Fly   855 GFGGVNPLYSDIVGISAYTVNDKQKDALQELVDTVKGSEYVPSTLQ--DSVDSNVNANYAWLASN 917
                    |...:.||..|.:...||.|||:....:..|...|.|.  .:|...:..|..||..|
Human   892 --------YDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKN 948

  Fly   918 RDPLMTWV 925
            ...|.||:
Human   949 LPTLRTWL 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31233	NP_732653.2	M1_APN-Q_like	65..509	CDD:341064	158/479 (33%)
		ERAP1_C	586..905	CDD:463368	86/347 (25%)
ERAP2	NP_071745.1	M1_APN-Q_like	76..543	CDD:341064	158/479 (33%)
		ERAP1_C	620..938	CDD:463368	86/349 (25%)