Protein Alignment CG31233 and LNPEP

DIOPT Version :10

• Sequence 1: NP_732653.2
• Gene: CG31233 / 42557
• FlyBaseID: FBgn0051233
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: XP_054208557.1
• Gene: LNPEP / 4012
• HGNCID: 6656
• Length: 1097
• Species: Homo sapiens
• Alignment Length: 966
• Identity: 274/966 - (28%)
• Similarity: 444/966 - (45%)
• Gaps: 160/966 - (16%)

  Fly    38 HLENPMQRLVVPLADED------NYRLPYDTIPSHYAVSLSTNVHTGDTVFNGTVAITLSVLNTT 96
            |.:|....|:.|.|...      ..|||...:|..|.:||..|:.:  ..|.|:|.|::..|..|
Human   214 HKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTS--MTFRGSVTISVQALQVT 276

  Fly    97 TKIVVHAR----QLENFTASIIQQGVTEAVAQELVYEYEAEREFLTFSKTGLTFPE----DTTWI 153
            ..|::|:.    ....|.:::..|   |..|:.|.|.|..:        ..:..||    ...:.
Human   277 WNIILHSTGHNISRVTFMSAVSSQ---EKQAEILEYAYHGQ--------IAIVAPEALLAGHNYT 330

  Fly   154 LTINYQGHLRTDNGGFYLSTYTDEEGNTKYLATTQFESTDARHAFPCYDEPSKRAEFTITIKHDP 218
            |.|.|..::.:...|||..:||||....||.|.||||...||.||||:|||:.:|.|.|.|..|.
Human   331 LKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDE 395

  Fly   219 SYNAISNMPVDSSST--SGVT--VFQKTVNMPSYLVAFIVSEFVFSEGELNG-------LPQRVF 272
            .|.|:||||..||..  .|:.  .|.::|.|.:|||||||.|......::||       :|:::
Human   396 QYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLVSIYAVPEKI- 459

  Fly   273 SRNGTEHEQEWALTTGMLVEKRLSGYFDVPFALPKLDQAGIPDFAAGAMENWGLATYREEYLLYN 337
               |..|   :||.|.:.:.:....||::.:.|.|||...||||.|||||||||.|:|||.|||:
Human   460 ---GQVH---YALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYD 518

  Fly   338 TENSTTSTQTNIATIEAHEDAHMWFGDLVAIEWWSFLWLKEGFATLFENLAVDLAYPEWDIFQTF 402
            :..|:.:.:..:..|.|||.||.|||:||.::||:.|||.|||||..|..:::..:.|...::.|
Human   519 SNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDF 583

  Fly   403 HAGSYQSALVNDASANARPMSHFVQKPSEIALLYDSVSYAKAGSVLDMWRHALTNTVFQRGLHNY 467
            ....::: :..|:..::.|:|..||...:|..::||:||.|..|:|.|.:..|:..|||..:..|
Human   584 LDARFKT-MKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLY 647

  Fly   468 LVDNQFTAANPSKLFEAIAKAAVEENYEVKATVPDMMGSWTNQGGVPLLTVTR-------NYDNG 525
            |.::.:.:.....|:::. .....:..:||.    ||.:||.|.|.||:||.:       ..:..
Human   648 LHNHSYASIQSDDLWDSF-NEVTNQTLDVKR----MMKTWTLQKGFPLVTVQKKGKELFIQQERF 707

  Fly   526 SFTVKQSVYTNDKDYTNDKLWYVPINYAESKNPDFRNTEATHYLLNQSEITIYSDLDQTN----- 585
            ...:|..:..:|..|    ||::|::|.         ||..:|...||    .|.||:.:
Human   708 FLNMKPEIQPSDTSY----LWHIPLSYV---------TEGRNYSKYQS----VSLLDKKSGVINL 755

  Fly   586 -----WLILNKKSTGYYRVLYDAQNYQLITSALITRPHKIDPRNRAQLINDLYRFATSGRVPHAT 645
                 |:.:|....|||.|.|...:::.:...|...|:.:..::||.|||:::..|..|:||...
Human   756 TEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKVPLKR 820

  Fly   646 LLELLTYLPQEDQYSPWS----ATNTVITLLNRYLSGDADYGN------FQFYVRELVSLQFDKF 700
            ..:|:.||..|:..:|.:    .|:.:..||.:.  |..|..:      |:....::....:...
Human   821 AFDLINYLGNENHTAPITEALFQTDLIYNLLEKL--GYMDLASRLVTRVFKLLQNQIQQQTWTDE 883

  Fly   701 GVNDNKGDHHLVPFTRNVLINLACLAGLENCLTETTAKL--TALVEEGTKIEP-NLQSQVYCNGL 762
            |....:.       .|:.|:..||...|.||.| |..||  ..:...||:..| ::.:.|:..|.
Human   884 GTPSMRE-------LRSALLEFACTHNLGNCST-TAMKLFDDWMASNGTQSLPTDVMTTVFKVGA 940

  Fly   763 KQADDKTFDFVFNKLLNSTDQAERRLLISALGCSQNTAQLEKFVYSSIEPEGLRDQERITVLSPV 827
            |  .||.:.|:..|.::...:||:..::.||..|::..:|...:.||:..:..|.|:...::..|
Human   941 K--TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTV 1003

  Fly   828 YSRGEVGLLVAIEFLQKNWEKYGQLNSGFGGVNPLYSDIVGISAYTVNDKQKDALQELVDTVKGS 892
             .|...|.|:|.:|:::||.|..|.              ..:.:|||.           :.|.||
Human  1004 -GRHFPGHLLAWDFVKENWNKLVQK--------------FPLGSYTVQ-----------NIVAGS 1042

  Fly   893 EYVPST-----------------------LQDSVDSNVNANYAWLASNRDPLMTWV 925
            .|:.||                       :|::::. :..|..|:..|...|..|:
Human  1043 TYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEV-IQLNIQWMEKNLKSLTWWL 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31233	NP_732653.2	M1_APN-Q_like	65..509	CDD:341064	157/462 (34%)
		ERAP1_C	586..905	CDD:463368	81/354 (23%)
LNPEP	XP_054208557.1	M1_APN-Q_like	247..684	CDD:341064	157/462 (34%)
		ERAP1_C	761..1081	CDD:463368	81/358 (23%)