Protein Alignment CG31233 and ANPEP

DIOPT Version :10

• Sequence 1: NP_732653.2
• Gene: CG31233 / 42557
• FlyBaseID: FBgn0051233
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_001141.2
• Gene: ANPEP / 290
• HGNCID: 500
• Length: 967
• Species: Homo sapiens
• Alignment Length: 916
• Identity: 290/916 - (31%)
• Similarity: 470/916 - (51%)
• Gaps: 71/916 - (7%)

  Fly    54 DNYRLPYDTIPSHYAVSLSTNVHTGDT---VFNGTVAITLSVLNTTTKIVVHARQLENFTAS--- 112
            :.||||....|..|.|:|...:...|.   ||.|:..:..:....|..|::|:::| |:|.|
Human    72 NRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKL-NYTLSQGH 135

  Fly   113 -IIQQGVTEAVAQEL-VYEYEAEREFLTFSKTGLTFPEDTTWILTINYQGHLRTDNGGFYLSTYT 175
             ::.:||..:...:: ..|.....|:|.....| :..:|:.:.:...::|.|..|..|||.|.|.
Human   136 RVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKG-SLVKDSQYEMDSEFEGELADDLAGFYRSEYM 199

  Fly   176 DEEGNT-KYLATTQFESTDARHAFPCYDEPSKRAEFTITIKHDPSYNAISNM-------PVDSSS 232
              |||. |.:||||.::.|||.:|||:|||:.:|||.||:.|.....|:|||       |:....
Human   200 --EGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDP 262

  Fly   233 TSGVTVFQKTVNMPSYLVAFIVSEFVFSEGEL-NGLPQRVFSRNG--TEHEQEWALTTGMLVEKR 294
            ...||.|..|..|.:||:|||||||.:.|.:. ||:..|:::|..  .....::||.....:...
Human   263 NWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNF 327

  Fly   295 LSGYFDVPFALPKLDQAGIPDFAAGAMENWGLATYREEYLLYNTENSTTSTQTNIATIEAHEDAH 359
            .:|::|.|:.|||.||.|:|||.|||||||||.||||..||::..:|::|.:..:.|:.|||.||
Human   328 FAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAH 392

  Fly   360 MWFGDLVAIEWWSFLWLKEGFATLFENLAVDLAYPEWDIFQTFHAGSYQSALVNDASANARPMS- 423
            .|||:||.||||:.|||.||||:..|.|..|.|.|.|::............:..||.|::.|:|
Human   393 QWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLST 457

  Fly   424 --HFVQKPSEIALLYDSVSYAKAGSVLDMWRHALTNTVFQRGLHNYLVDNQFTAANP--SKLFEA 484
              ..:..|::|:.|:|::||:|..|||.|....|:..||::||.:||  :.|...|.  ..|::.
Human   458 PASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYL--HTFAYQNTIYLNLWDH 520

  Fly   485 IAKAAVEENYEVKATVPDMMGSWTNQGGVPLLTVTRNYDNGSFTVKQSVYTNDKDYTNDK----- 544
            :.:|....:.::..||.|:|..||.|.|.|::||    |..:.|:.|..:..|.|....:
Human   521 LQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITV----DTSTGTLSQEHFLLDPDSNVTRPSEFN 581

  Fly   545 -LWYVPINYAESKNPDFRNTEATHYLLNQSEITIYSDLDQTN---WLILNKKSTGYYRVLYDAQN 605
             :|.|||....    |.|. :..::|:   ::...:||..|:   |::||...||||||.||.:|
Human   582 YVWIVPITSIR----DGRQ-QQDYWLI---DVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEEN 638

  Fly   606 YQLITSALITRPHKIDP-RNRAQLINDLYRFATSGRVPHATLLELLTYLPQEDQYSPWSATNTVI 669
            ::.|.:.| .|.|...| .||||:|||.:..|::.:||....|....:|.:|.||.||.|..:.:
Human   639 WRKIQTQL-QRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSL 702

  Fly   670 TLLNRYLSGDADYGNFQFYVRELVSLQFDKFGVNDNK----GDHHLVPFTRNVLINLACLAGLEN 730
            :...........||..:.|:::.|:..|..|..|.|.    .::.:..::....|:.||..|:..
Human   703 SYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPE 767

  Fly   731 CLTETTAKLTALVE--EGTKIEPNLQSQVYCNGLKQADDKTFDFVFNKLLNSTDQAERRLLISAL 793
            |....:......:|  ....|.|||:|.||||.:.|..::.:||.:.:..|:|...|...|.:||
Human   768 CEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAAL 832

  Fly   794 GCSQNTAQLEKFVYSSIEPEGLRDQERITVLSPVYSRGEVGLLVAIEFLQKNWEKYGQLNSGFGG 858
            .||:....|.:::..::.|:.:|.|:..:.:..: :...:|..:..:|:|.||:|   |.:.:||
Human   833 ACSKELWILNRYLSYTLNPDLIRKQDATSTIISI-TNNVIGQGLVWDFVQSNWKK---LFNDYGG 893

  Fly   859 VNPLYSDIVGISAYTVNDKQKDALQELVDTVKGSEYV-----PSTLQDSVDSNVNANYAWLASNR 918
            .:..:|::  |.|.|.....:..||:|....|.:|..     ...|:.::: ...||..|:..|:
Human   894 GSFSFSNL--IQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALE-KTKANIKWVKENK 955

  Fly   919 DPLMTW 924
            :.::.|
Human   956 EVVLQW 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31233	NP_732653.2	M1_APN-Q_like	65..509	CDD:341064	167/467 (36%)
		ERAP1_C	586..905	CDD:463368	92/330 (28%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..62
		Metalloprotease	69..967		290/916 (32%)
		M1_APN-Q_like	84..545	CDD:341064	167/466 (36%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485	288..295		1/6 (17%)
		ERAP1_C	619..946	CDD:463368	92/334 (28%)