Protein Alignment CG31233 and LVRN

DIOPT Version :10

• Sequence 1: NP_732653.2
• Gene: CG31233 / 42557
• FlyBaseID: FBgn0051233
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_776161.3
• Gene: LVRN / 206338
• HGNCID: 26904
• Length: 990
• Species: Homo sapiens
• Alignment Length: 1018
• Identity: 278/1018 - (27%)
• Similarity: 454/1018 - (44%)
• Gaps: 153/1018 - (15%)

  Fly     6 VGGMSVFLVLLLAISAT-----QAAVVRQYPILDHLQHLENPMQR--------------LVV--- 48
            :.|:...|:|.||:.|.     :.....:.|.|..|:...:|..|              |.|
Human    19 LAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSPPLRQKPTPTPKPSSARELAVTTT 83

  Fly    49 -----PLADEDNYRLPYDTIPSHYAVSL-----STNVHTGDTVFNGTVAITLSVLNTTTKIVVHA 103
                 |....|..|||...:|.||.:.|     ...:..|...|.|.|.||:.....|:::::|:
Human    84 PSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHS 148

  Fly   104 RQLENFTASI---IQQGVTEAVAQELVYE---YEAEREFLTFSKTGLTFPEDTTWILTINYQGHL 162
            ...:...|.:   :..|...|....:..:   :..:.|::....:....| .:::.|.:::.|.:
Human   149 LFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKP-GSSYELQLSFSGLV 212

  Fly   163 RTD-NGGFYLSTYTDEEGNTKYLATTQFESTDARHAFPCYDEPSKRAEFTITIKHDPSYNAISNM 226
            :.| ..|.:|:.||| :|..:.|..:|.|.|.||:.|||:|||:.:|.|.||:.|.|||.|:|||
Human   213 KEDLREGLFLNVYTD-QGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVALSNM 276

  Fly   227 P----VDSSSTSG----VTVFQKTVNMPSYLVAFIVSEFVFSEGELNGLPQRVFSR-----NGTE 278
            |    .:....:|    ||.|..|.:||:|||||::.::........|...|:::|     ||:
Human   277 PKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTERGKEIRIWARKDAIANGS- 340

  Fly   279 HEQEWALTTGMLVEKRLSGYFDVPFALPKLDQAGIPDFAAGAMENWGLATYREEYLLYNTENSTT 343
              .::||.....:...|...|::.::|||.|...:|.|...|||||||..:.|..||...::..|
Human   341 --ADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLT 403

  Fly   344 STQTNIATIEAHEDAHMWFGDLVAIEWWSFLWLKEGFATLFENLAVDLAYPEWDIFQTFHAGSYQ 408
            ..:|.|:.:.:||..|.|||:||.:.||:.:||.||||:.||...::...|:....:.|.:....
Human   404 EKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILH 468

  Fly   409 SALVNDASANARPMSHFVQ--KPSEIALLYDSVSYAKAGSVLDMWRHALTNTVFQRGLHNYLVDN 471
            :.|..|.:...|.::..|:  |.|||..|:|..:|:|..|:..|....|...:|...|.:||...
Human   469 NILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTF 533

  Fly   472 QFTAANPSKLFEAIAKAAVEENYEV-KATVPDMMGSWTNQGGVPLLTVTRNYDNGSFTVKQSVYT 535
            .::.|....|:.....|..:::..: .||:.::|.|||:|.|.|::|:  |...|....:.....
Human   534 SYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITL--NVSTGVMKQEPFYLE 596

  Fly   536 NDKD---YTNDKLWYVPINYAESKNPDFRNTEATHYLLNQS-----EITIYSDLDQTNWLILNKK 592
            |.|:   .|::..|.|||.:.::      .|......|:||     |:.: ||.|. :|:|||..
Human   597 NIKNRTLLTSNDTWIVPILWIKN------GTTQPLVWLDQSSKVFPEMQV-SDSDH-DWVILNLN 653

  Fly   593 STGYYRVLYDAQNYQLITSALITRPHKIDPRNRAQLINDLYRFATSGRVPHATLLELLTYLPQED 657
            .||||||.||...::.:...|...|..|...:|.|||:|.:..:.:..:...|.|||..||.:||
Human   654 MTGYYRVNYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEED 718

  Fly   658 QYSPW-------------SATN--TVITLLNRYLSGDAD--YGNFQFYVRE-LVSLQFDKFGVND 704
            :...|             |..|  .:.:||.|||....:  :..:...:|| :::||
Human   719 EIIVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQ-------- 775

  Fly   705 NKGDHHLVPFTRNVLINLACLAGLENCL---TETTAKLTALVEEGTKIEPNLQSQVYCNGLKQAD 766
               |.:|...:...|...||..|||:||   .|..||.....|  .:|...::..|.|.|:....
Human   776 ---DDYLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPE--NEIPYPIKDVVLCYGIALGS 835

  Fly   767 DKTFDFVFNKLLNSTDQAERRLLISALGCSQNTAQLEKFVYSSIEPEGLRDQERITVLSPVYSRG 831
            ||.:|.:.|...|:|::.|:..|..|:.||::...|.:::..:|........|  |.:..|.:..
Human   836 DKEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNE--TNIIEVVASS 898

  Fly   832 EVGLLVAIEFLQKNWE----KYGQLNSGFGGVNPLYSDIVGISAYTVNDKQKDALQELVDTVKGS 892
            |||..||.:||..||:    :||..:.    :|.:|:    |......|.|...||
Human   899 EVGRYVAKDFLVNNWQAVSKRYGTQSL----INLIYT----IGRTVTTDLQIVELQ--------- 946

  Fly   893 EYVPSTLQDSVDSNVNANY------------------AWLASN 917
            ::..:.|::.....|:||.                  |||..|
Human   947 QFFSNMLEEHQRIRVHANLQTIKNENLKNKKLSARIAAWLRRN 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31233	NP_732653.2	M1_APN-Q_like	65..509	CDD:341064	137/471 (29%)
		ERAP1_C	586..905	CDD:463368	93/343 (27%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..91		8/42 (19%)
		M1_APN-Q_like	105..572	CDD:341064	137/471 (29%)
		ERAP1_C	647..970	CDD:463368	96/354 (27%)