DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31233 and Lnpep

DIOPT Version :10

Sequence 1:NP_732653.2 Gene:CG31233 / 42557 FlyBaseID:FBgn0051233 Length:952 Species:Drosophila melanogaster
Sequence 2:NP_001106874.1 Gene:Lnpep / 171105 RGDID:621752 Length:1025 Species:Rattus norvegicus


Alignment Length:952 Identity:278/952 - (29%)
Similarity:455/952 - (47%) Gaps:75/952 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VFLVLLLAISATQAAVVRQYPILDHLQ---HLENPMQRLVVPLADED------NYRLPYDTIPSH 66
            |..|.::.::.:...|:...|.....:   |..|....|:.|:|...      ..|||...||..
  Rat   112 VICVFVIVVAVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQR 176

  Fly    67 YAVSLSTNVHTGDTVFNGTVAITLSVLNTTTKIVVHARQLENFTASIIQQGVTEAVAQELVYEYE 131
            |.:||..|:.:  ..|.|:|.|:|..|..|..|::|:.. .|.::......|:....|..:.||.
  Rat   177 YELSLHPNLTS--MTFRGSVTISLQALQDTRDIILHSTG-HNISSVTFMSAVSSQEKQVEILEYP 238

  Fly   132 AEREFLTFSKTGLTFPEDTTWILTINYQGHLRTDNGGFYLSTYTDEEGNTKYLATTQFESTDARH 196
            ...:....:...|....:.|  |.|.|..::.....|||..||||:....|..|.||||...||.
  Rat   239 YHEQIAVVAPESLLTGHNYT--LKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAARS 301

  Fly   197 AFPCYDEPSKRAEFTITIKHDPSYNAISNMPVDSS--STSGV--TVFQKTVNMPSYLVAFIVSEF 257
            ||||:|||:.:|.|.|.|..|..:.|:||||..||  :..|:  ..|.::|.|.:|||||||   
  Rat   302 AFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYLVAFIV--- 363

  Fly   258 VFSEGELNGLPQRVFSRNGT---------EHEQEW-ALTTGMLVEKRLSGYFDVPFALPKLDQAG 312
                ||:..|.|.|   |||         :.:|.: ||.|.:.:.:....||::.:.|.|||...
  Rat   364 ----GEMRNLSQDV---NGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLVA 421

  Fly   313 IPDFAAGAMENWGLATYREEYLLYNTENSTTSTQTNIATIEAHEDAHMWFGDLVAIEWWSFLWLK 377
            ||||.|||||||||.|:|||.|||:...|:.:.:..:..|.|||.||.|||:||.::||:.|||.
  Rat   422 IPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLN 486

  Fly   378 EGFATLFENLAVDLAYPEWDIFQTFHAGSYQSALVNDASANARPMSHFVQKPSEIALLYDSVSYA 442
            |||||..|..:|:..:.|.:.::.|....::: :..|:..::.|:|..||...:|..::||:||.
  Rat   487 EGFATFMEYFSVEKIFKELNSYEDFLDARFKT-MRKDSLNSSHPISSSVQSSEQIEEMFDSLSYF 550

  Fly   443 KAGSVLDMWRHALTNTVFQRGLHNYLVDNQFTAANPSKLFEAIAKAAVEENYEVKATVPDMMGSW 507
            |..|:|.|.:..|:..|||..:..||.::.:.|.....|:::. .....:..:||    .||.:|
  Rat   551 KGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSF-NEVTGKTLDVK----KMMKTW 610

  Fly   508 TNQGGVPLLTVTRNYDNGSFTVKQ------SVYTNDKDYTNDKLWYVPINYAESKNPDFRN-TEA 565
            |.|.|.||:||.|   .|:..:.|      |:....:|.....||::||:|.    .|.|| :|.
  Rat   611 TLQKGFPLVTVQR---KGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYV----TDGRNYSEY 668

  Fly   566 THYLLNQSEITIYSDLDQTNWLILNKKSTGYYRVLYDAQNYQLITSALITRPHKIDPRNRAQLIN 630
            ....|...:..:.:..:|..|:.:|...||||.|.|....:..:.:.|...|:.:..::||.|||
  Rat   669 RSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPYVLSDKDRANLIN 733

  Fly   631 DLYRFATSGRVPHATLLELLTYLPQEDQYSPWS----ATNTVITLLNRYLSGDADYGN-FQFYVR 690
            :::..|..|:||.....:|:.||..|...:|.:    .|:.:..||.:.  |..|..: ....|.
  Rat   734 NIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKL--GHMDLSSRLVTRVH 796

  Fly   691 ELVSLQFDKFGVNDNKGDHHLVPFTRNVLINLACLAGLENCLTETTAKLTA-LVEEGTKIEP-NL 753
            :|:..|..:....| :|...:... |:.|:..||...||||.|..|..... :...||:..| ::
  Rat   797 KLLQNQIQQQTWTD-EGTPSMREL-RSALLEFACAHSLENCTTMATKLFDGWMASNGTQSLPTDV 859

  Fly   754 QSQVYCNGLKQADDKTFDFVFNKLLNSTDQAERRLLISALGCSQNTAQLEKFVYSSIEPEGLRDQ 818
            .:.|:..|.:  .:|.:.|:|:...:...:||:..::.||..|.:..:|...:.||::.:.:|.|
  Rat   860 MTTVFKVGAR--TEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLYWLMKSSLDGDIIRTQ 922

  Fly   819 ERITVLSPVYSRGEVGLLVAIEFLQKNWEKYGQLNSGFGGVNPLYSDIVGISAYTVNDKQKDALQ 883
             :::::.....|...|.|:|.:|:::||.|.  ::....|...:.|.:.|.:...........:|
  Rat   923 -KLSLIIRTVGRQFPGHLLAWDFVKENWNKL--VHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQ 984

  Fly   884 ELVDTVKGSEYVPSTLQDSVDSNVNANYAWLASNRDPLMTWV 925
            |..:....:......:|::.:. :..|..|:|.|...|..|:
  Rat   985 EFFENQSEATLQLRCVQEAFEV-IELNIQWMARNLKTLTLWL 1025

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31233NP_732653.2 M1_APN-Q_like 65..509 CDD:341064 159/457 (35%)
ERAP1_C 586..905 CDD:463368 76/325 (23%)
LnpepNP_001106874.1 Dileucine internalization motif. /evidence=ECO:0000255 53..54
Dileucine internalization motif. /evidence=ECO:0000255 76..77
Tankyrase binding. /evidence=ECO:0000250 96..101
M1_APN-Q_like 176..612 CDD:341064 159/456 (35%)
ERAP1_C 689..1009 CDD:463368 76/329 (23%)
Blue background indicates that the domain is not in the aligned region.

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