Protein Alignment CG5849 and AAP1

DIOPT Version :10

• Sequence 1: NP_650979.1
• Gene: CG5849 / 42556
• FlyBaseID: FBgn0038897
• Length: 968
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 950
• Identity: 234/950 - (24%)
• Similarity: 422/950 - (44%)
• Gaps: 149/950 - (15%)

  Fly    31 LPNATYPLFYQLHISSDIHKGQLLFSGNATIDVAIRQSTNEIVLHAKNLTDIQITVHRLMAEGSE 95
            |||...||.|.:.:..:..  ...|.|:..||:.|    |:..:::..:..::|..|....||..
Yeast     6 LPNNVTPLHYDITLEPNFR--AFTFEGSLKIDLQI----NDHSINSVQINYLEIDFHSARIEGVN 64

  Fly    96 IVDDLTHTLHPTAALLIIHPIENYQ---------AFEE-GQQYRLEILYTAIMASRPAGLYYMDY 150
            .::              ::..||.|         .||. |...:|||:::.|:..:.||.|...|
Yeast    65 AIE--------------VNKNENQQKATLVFPNGTFENLGPSAKLEIIFSGILNDQMAGFYRAKY 115

  Fly   151 RDEENNHTVYVAATQCEPTYGRLIFPCYDEPGFKSNFSIKITHGSSHSAISNMPVK-EVLAHGDL 214
            .|:....|.|:|.||.|.|..|..|||:|||..|:.|::.:...|..:.:|||.|: |.:..|.
Yeast   116 TDKVTGETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNETIKEGK- 179

  Fly   215 KTTSFHTTPPISTYLVAFVISDFGSISETYRGITQSIYTSPTSKEKGQVALKNAVRTVAALEDYF 279
            |.|:|:|||.:|||||||:::|...:......|...:|::|..::.||.|...|.||:...||.|
Yeast   180 KYTTFNTTPKMSTYLVAFIVADLRYVESNNFRIPVRVYSTPGDEKFGQFAANLAARTLRFFEDTF 244

  Fly   280 GVSYPLPKLDHVALKKNYGAAMENWGLITYKDVNLL---KNISSDGQKRKLDLITQNHEIAHQWF 341
            .:.|||||:|.||:.:....|||||||:||:.::||   :|.|.|..:|..::|  .||:|||||
Yeast   245 NIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVI--QHELAHQWF 307

  Fly   342 GNLVSPEWWTYTWMNEGFATYFSYVITDLIYPNDKMMDMFMTHEADSAYSYNSFFDVHPMSHYVE 406
            ||||:.:||...|:||||||:.|:...:...|..|:.:.::|.....|.:.:|....||:...|.
Yeast   308 GNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVN 372

  Fly   407 GEKDIMGVFDIISYKRGACVIKMFHHAFRQKLFVRGISHFLEKYRYSVANELNLFDALHSELQDD 471
            ...:|..:||.|||.:|:.:::|......::.|::|:|.:|.|::|..|...:|:|||......|
Yeast   373 NADEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGKD 437

  Fly   472 EYFSHQPWASRIREIMLSWTHSEWLPILVVTRNYENNTITFTQR------SVHMKDELWWIPINF 530
                       :..:|..||.....|:|.|..:  .|.||.||.      .|..:::....||..
Yeast   438 -----------VCSVMNIWTKRVGFPVLSVKEH--KNKITLTQHRYLSTGDVKEEEDTTIYPILL 489

  Fly   531 ATTQSPNFEDTQVDMFMPPQPQYTVSLEDLNIHVSGRDWIMVNKQHTGFYLVRYDTDNLMAIARQ 595
            |...|...::|.|           ::.:.....:...::..:|...:|.::..|..:....:::|
Yeast   490 ALKDSTGIDNTLV-----------LNEKSATFELKNEEFFKINGDQSGIFITSYSDERWAKLSKQ 543

  Fly   596 LQTNHSVIHPINRLGLFRDLGPLIEHNEIEQVEVVFELLKYLELEEDVLTWNQLQDTIECLTRNL 660
            .    :::...:|:||..|...|...........: .|:...:.|:..:.|.|:.:::..| ::.
Yeast   544 A----NLLSVEDRVGLVADAKALSASGYTSTTNFL-NLISNWKNEDSFVVWEQIINSLSAL-KST 602

  Fly   661 HGTSSQSLFNEFVRRLVGPTFRRVYVEQGVNLAEDGMFR------GILEIACSADLPECLEYTRR 719
            .....:.:.|...:..:.....:: .|.|.|:.||..|.      .:...||::...:.......
Yeast   603 WVFEPEDILNALDKFTLDLVLNKL-SELGWNIGEDDSFAIQRLKVTLFSAACTSGNEKMQSIAVE 666

  Fly   720 LAKEHIIDKIYFKDGSD------YHAII-DSVLCMGVRYLSDQDFQRIIDMMQEIDRASVYYDDI 777
            :.:|       :.:|:.      :.|:: ::|..:|    .:.::::|.::.|.    .|..::.
Yeast   667 MFEE-------YANGNKQAIPALFKAVVFNTVARLG----GENNYEKIFNIYQN----PVSSEEK 716

  Fly   778 IYALRCTQS-------HRHLLYYLEGLMGENSTHMVLSEFEDLMYLLYIYKSNLASRPVIWQYIE 835
            |.|||....       .|.|.|.|:|.       ::..:|...|..:.::|..:..   :|.:::
Yeast   717 IIALRALGRFEDKELLERTLSYLLDGT-------VLNQDFYIPMQGIRVHKKGIER---LWAWMQ 771

  Fly   836 RNYKVLCRAPNFLEHFKQLAGFVPRHQRSHFERLR--QTIANHMMQEGLNTNQTLIE-VDSPLVG 897
                         ||:.::|           :||:  ..:...::..|| ||.|..| ::.....
Yeast   772 -------------EHWDEIA-----------KRLQPGSPVLGGVLTLGL-TNFTSFEALEKISAF 811

  Fly   898 KKMKITENFQDKFEQQIHKWLLNELPQATSRSDALLSASL 937
            ...|:|:.|.....|.:.  .:....|..||...:::..|
Yeast   812 YSRKVTKGFDQTLAQALD--TIRSKAQWVSRDREIVATYL 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5849	NP_650979.1	M1_APN-Q_like	38..492	CDD:341064	151/467 (32%)
		ERAP1_C	569..841	CDD:463368	44/291 (15%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	151/467 (32%)
		ERAP1_C	517..833	CDD:463368	59/374 (16%)