Protein Alignment CG5849 and Npepps

DIOPT Version :10

• Sequence 1: NP_650979.1
• Gene: CG5849 / 42556
• FlyBaseID: FBgn0038897
• Length: 968
• Species: Drosophila melanogaster
• Sequence 2: NP_536320.1
• Gene: Npepps / 50558
• RGDID: 619962
• Length: 920
• Species: Rattus norvegicus
• Alignment Length: 1005
• Identity: 268/1005 - (26%)
• Similarity: 422/1005 - (41%)
• Gaps: 200/1005 - (19%)

  Fly     3 TPPSGVVVLV-----------TLGLLVSGSMGERERSLRLPNATYPLFYQLHISSDIHKGQLLFS 56
            :||..:::|:           :|||   .:|.|:....|||....|:.|.|.:..|:.  ...|.
  Rat    19 SPPPPLLLLLSRSSSRRRRLHSLGL---AAMPEKRPFERLPTEVSPINYSLCLKPDLL--DFTFE 78

  Fly    57 GNATIDVAIRQSTNEIVLHAKNLTDIQITVHRLMAEGSEIVDDLTHTLHPTAALLIIHPIENYQA 121
            |.......:||:||:||:   |..||.|.......||.|       .:|.|..        |||.
  Rat    79 GKLEAAAQVRQATNQIVM---NCADIDIITASYAPEGDE-------EIHATGF--------NYQN 125

  Fly   122 FEEGQQY-----------RLEILYTAIMASRPAGLYYMDYRDEENNHTVYVAATQCEPTYGRLIF 175
            .:|....           .|:|.:...:..:..|.|...|.... ....|.|.||.|.|..|..|
  Rat   126 EDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSRYTTPA-GEVRYAAVTQFEATDARRAF 189

  Fly   176 PCYDEPGFKSNFSIKITHGSSHSAISNMPVKEVLAHGD---LKTTSFHTTPPISTYLVAFVISDF 237
            ||:|||..|:.|.|.:.......|:|||.|.:...:.|   |....|..||.:||||||||:.::
  Rat   190 PCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEY 254

  Fly   238 GSI-SETYRGITQSIYTSPTSKEKGQVALKNAVRTVAALEDYFGVSYPLPKLDHVALKKNYGAAM 301
            ..: :.:..|:...:||.....|:|:.||:.|.:|:...:|||.|.|||||:|.:|:......||
  Rat   255 DFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAM 319

  Fly   302 ENWGLITYKDVNLL---KNISSDGQKRKLDLITQNHEIAHQWFGNLVSPEWWTYTWMNEGFATYF 363
            |||||:||::..||   ||  |....|:...:...||:|||||||||:.||||:.|:|||||::.
  Rat   320 ENWGLVTYRETALLIDPKN--SCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWI 382

  Fly   364 SYVITDLIYPNDKMMDMFMTHEADSAYSYNSFFDVHPMSHYVEGEKDIMGVFDIISYKRGACVIK 428
            .|:..|..:|...:...|::.:...|...::..:.||:...|....::..:||.|||.:||.||:
  Rat   383 EYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIR 447

  Fly   429 MFHHAFRQKLFVRGISHFLEKYRYSVANELNLFDALHSELQDDEYFSHQPWASRIREIMLSWTHS 493
            |.|.....|.|.:|::.:|.|::...|...:|:::|.|.       |.:|    |..:|.:||..
  Rat   448 MLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLESA-------SGKP----IAAVMNTWTKQ 501

  Fly   494 EWLPILVV-TRNYENNTI------TFTQRSVHMKDEL--WWIPINFATTQSPNFEDTQVDMFMPP 549
            ...|::.| ....|::.:      .|.....::.::.  |.:||..:|::.||....::.|   .
  Rat   502 MGFPLIYVEAEQVEDDRVLKLSQKKFCASGPYVGEDCPQWMVPITISTSEDPNQAKLKILM---D 563

  Fly   550 QPQYTVSLEDLNIHVSGRDWIMVNKQHTGFYLVRYDT---DNLMAIARQLQTNHSVIHPINRLGL 611
            :|:.:|.|:    :|....|:.:|....|||..:|.:   ::|:...|.|.     :.|::||||
  Rat   564 KPEMSVVLK----NVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLS-----LPPVDRLGL 619

  Fly   612 FRDLGPLIEHNEIEQVEVVFELLKYLEL---EEDVLTWNQLQDTIECLTRNLHGTSSQSLFNEFV 673
            ..||..|.....|..|||    ||.:|.   |.:...|:.|...:..|:..|..|.......|||
  Rat   620 QNDLFSLARAGIISTVEV----LKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFV 680

  Fly   674 RRLVGPTFRRVYVEQGVNLAE-DGMFRG-ILEIACSADLPECLEYTRRLAKEHIIDK-------- 728
            :.:..|...|:..:....... |.:.|| :|.....|.....||..||..|||:..|
  Rat   681 KDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKEHVEGKQILSADLR 745

  Fly   729 --IYFK-----DGSDYHAIIDSVLCMGVRYLSDQDFQRIIDMMQEIDR-----ASVYYDDII--- 778
              :|..     ||:    .:|.:|          ...:..||.:|.:|     .:....::|
  Rat   746 SPVYLTVLKHGDGT----TLDIML----------KLHKQADMQEEKNRIERVLGATLSPELIQKV 796

  Fly   779 --YALRCTQSHRHLLYYLEGLMGENSTHMVLSEFEDLMYLLYIYKSNLASRPVIWQYIERNYKVL 841
              :||......:..:..:.|:.| .|.|                     .|...|::|:.|::.|
  Rat   797 LTFALSEEVRPQDTVSVIGGVAG-GSKH---------------------GRKAAWKFIKDNWEEL 839

  Fly   842 CR--APNFL---------EHF--KQLAG----FVPRHQRSHFERLRQTIANHMMQEGLNTNQTLI 889
            ..  ...||         |.|  .::||    |...|.....||..|....:::   ||......
  Rat   840 YNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENIL---LNAAWLKR 901

  Fly   890 EVDSPLVGKKMKITENFQDKFEQQIHKWLL 919
            :.||                    ||::||
  Rat   902 DADS--------------------IHQYLL 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5849	NP_650979.1	M1_APN-Q_like	38..492	CDD:341064	152/471 (32%)
		ERAP1_C	569..841	CDD:463368	68/304 (22%)
Npepps	NP_536320.1	M1_APN-Q_like	62..500	CDD:341064	152/471 (32%)
		ERAP1_C	579..892	CDD:463368	80/357 (22%)