DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-alpha180 and POL3

DIOPT Version :9

Sequence 1:NP_536736.2 Gene:DNApol-alpha180 / 42553 FlyBaseID:FBgn0259113 Length:1488 Species:Drosophila melanogaster
Sequence 2:NP_010181.2 Gene:POL3 / 851456 SGDID:S000002260 Length:1097 Species:Saccharomyces cerevisiae


Alignment Length:1339 Identity:309/1339 - (23%)
Similarity:512/1339 - (38%) Gaps:373/1339 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   199 NIKVQEQERKKAEASSDNEMLERILKPKA------AVPNTKVAFFSSPTIKKEPMPEKTPAKKAT 257
            ::|:.::         |...||:.:|.::      :.|.:.:....|.:.:|.            
Yeast    11 DVKIDDE---------DTPQLEKKIKRQSIDHGVGSEPVSTIEIIPSDSFRKY------------ 54

  Fly   258 EDPFSDNEMDFSCLDDD------ENQFDVEKTQQTEKVSQTKTAAEKTSQSKVAEKSAPKKETTG 316
                  |...|...|.|      |:.|:.|.:|....::.    .|:...|....|..|   |..
Yeast    55 ------NSQGFKAKDTDLMGTQLESTFEQELSQMEHDMAD----QEEHDLSSFERKKLP---TDF 106

  Fly   317 SPKESESEDISRLLNNWESICQMDDDFEKSVLTTEQDSTISSDQQLRFWYWEAYEDPVKMPGEVF 381
            .|   ...|||     ::.|     |.|:|||...:|...|:  .:||                 
Yeast   107 DP---SLYDIS-----FQQI-----DAEQSVLNGIKDENTST--VVRF----------------- 139

  Fly   382 LFGRTADGKSVCLRVQNINRVLYLLPRQFLLDPISKEPTKQKVTVADIYKEFDSEVANQLKLEFF 446
             ||.|::|.||...|......|| :|.     |.|.:..             |.|..|:      
Yeast   140 -FGVTSEGHSVLCNVTGFKNYLY-VPA-----PNSSDAN-------------DQEQINK------ 178

  Fly   447 RSRKVTKSFAH-------HAIGIEVPQSCDYLEV-------HYDGKKPLPNLSADKKYNSIAHIF 497
                    |.|       |||        |.:||       .|.|...||..   |.|.:..|:.
Yeast   179 --------FVHYLNETFDHAI--------DSIEVVSKQSIWGYSGDTKLPFW---KIYVTYPHMV 224

  Fly   498 GATTNALE------------------------RFLLDRKIKGPCWLQVTGFKVS----PTPMSWC 534
            .....|.|                        |.::|..|.|..|:.:...|.|    ...:|.|
Yeast   225 NKLRTAFERGHLSFNSWFSNGTTTYDNIAYTLRLMVDCGIVGMSWITLPKGKYSMIEPNNRVSSC 289

  Fly   535 NTEVTLTEPKNVELVQDKGKPAPPPPLTLLSLNV----RTSMNPKTSRNEICMISMLTHNRFHI- 594
            ..||::.. :|:.....:|..:...||.::|.::    |..:.|:...:.:..|:    |...| 
Yeast   290 QLEVSINY-RNLIAHPAEGDWSHTAPLRIMSFDIECAGRIGVFPEPEYDPVIQIA----NVVSIA 349

  Fly   595 --DRPAPQPAFNRHMCALTRPAVVSWPLDLNFEMAKYKSTTVHKHDSERALLS-W--FLAQYQKI 654
              .:|..:..|..:.|:         |:         ..:.:..|.:|..:|| |  |:.   |:
Yeast   350 GAKKPFIRNVFTLNTCS---------PI---------TGSMIFSHATEEEMLSNWRNFII---KV 393

  Fly   655 DADLIVTFDSMDCQLNVITDQIVALKIPQWSRMGRLRL-----------SQSFGKRLLE--HFVG 706
            |.|:|:.:::.:..:..:.::..|||:..:...|||:.           |:::|.|..:  :..|
Yeast   394 DPDVIIGYNTTNFDIPYLLNRAKALKVNDFPYFGRLKTVKQEIKESVFSSKAYGTRETKNVNIDG 458

  Fly   707 RMVCDVKRSAEECIRARSYDLQTLCKQVL-KLKESERMEVNADDLLEMYEKGESIT--KLISLTM 768
            |:..|:.:..:...:.|||.|..:....| :.||.....:.:|     .:.|:|.|  :|....:
Yeast   459 RLQLDLLQFIQREYKLRSYTLNAVSAHFLGEQKEDVHYSIISD-----LQNGDSETRRRLAVYCL 518

  Fly   769 QDNSYLLRLMCELNIMPLALQITNICGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPDKKPVSK 833
            :|....||||.:|..:....::..:.|...:..|..|:..:....|.....|.:.::|     :.
Yeast   519 KDAYLPLRLMEKLMALVNYTEMARVTGVPFSYLLARGQQIKVVSQLFRKCLEIDTVIP-----NM 578

  Fly   834 RSGAGDTDATLSGADATMQTKKKAAYAGGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTT 898
            :|.|.|..                 |.|..|:||:||.|:..:..:|||||||||:..:|:|:||
Yeast   579 QSQASDDQ-----------------YEGATVIEPIRGYYDVPIATLDFNSLYPSIMMAHNLCYTT 626

  Fly   899 ---------VQQPVDADELPTLPD------SKTEPGILPLQLKRLVESRKEVKKLMAAPDL---- 944
                     :...:|.|.:.| |:      :|...||||:.|..|:.:||..||     ||    
Yeast   627 LCNKATVERLNLKIDEDYVIT-PNGDYFVTTKRRRGILPIILDELISARKRAKK-----DLRDEK 685

  Fly   945 SPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKGREILTNTQQLVQ-----KM 1004
            .|..:...:.||:|||::|||:||..|....:.....:::.||..||.::..|:..||     |.
Yeast   686 DPFKRDVLNGRQLALKISANSVYGFTGATVGKLPCLAISSSVTAYGRTMILKTKTAVQEKYCIKN 750

  Fly  1005 NYD----VVYGDTDSLMINTNITDYDQVYKIGHNIKQSVNKLYKQ-LELDIDGVFGCLLLLKKKK 1064
            .|.    ||||||||:|:....||..:...:|....:.|:.|:|. :.|:.:..:...||:.||:
Yeast   751 GYKHDAVVVYGDTDSVMVKFGTTDLKEAMDLGTEAAKYVSTLFKHPINLEFEKAYFPYLLINKKR 815

  Fly  1065 YAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSEKPLEEKLDAVHAQLEKI 1129
            ||.:..:...|.:   :.:.|||..||||...|..:|...||.::|    :|..:|...|.:.:.
Yeast   816 YAGLFWTNPDKFD---KLDQKGLASVRRDSCSLVSIVMNKVLKKIL----IERNVDGALAFVRET 873

  Fly  1130 KTQIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQVALRMNRERNRRYKKGDMVDYVICLDGT 1194
            ...|....|.:...:|:|.|.   ..|.|..  ||..:|.||.|........||.|||||.  |.
Yeast   874 INDILHNRVDISKLIISKTLA---PNYTNPQ--PHAVLAERMKRREGVGPNVGDRVDYVII--GG 931

  Fly  1195 TNAAMQRAYHLDELKTSEDKKLQLDTNYYLGHQI-HPVVTRMVEVLEGTDASRIAECLGMDPTKF 1258
            .:....||.  |.|...|: .:|:|:.|||.:|: :|:::.:..::....|:      ||...| 
Yeast   932 NDKLYNRAE--DPLFVLEN-NIQVDSRYYLTNQLQNPIISIVAPIIGDKQAN------GMFVVK- 986

  Fly  1259 RQNAQRTQRENTEQSEG--ESLLKTTLQLYRLCEPFRFQCVTCKTEQLMASAYRPGPSNSHIAVL 1321
                  :.:.||...:|  .|.:|..           ..|.:||           ||        
Yeast   987 ------SIKINTGSQKGGLMSFIKKV-----------EACKSCK-----------GP-------- 1015

  Fly  1322 QQCAKSECQTAPIQYLASVRNQLQLSMRQYVQRFYKNWLVCDHPDCNFNTRTHSLRKKSHR--PL 1384
              ..|.|   .|:     ..|.|..|...|::..|.               ...|.:|..|  ..
Yeast  1016 --LRKGE---GPL-----CSNCLARSGELYIKALYD---------------VRDLEEKYSRLWTQ 1055

  Fly  1385 CQKCRSGSLLRQYTERDLYNQLCYLRFMFDLGKQTLQQK 1423
            ||:| :|:|   ::|....|:.|.:.:|....|:.||:|
Yeast  1056 CQRC-AGNL---HSEVLCSNKNCDIFYMRVKVKKELQEK 1090

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-alpha180NP_536736.2 DNA_pol_alpha_N 24..83 CDD:289058
pol2 52..1237 CDD:273159 271/1147 (24%)
DNA_polB_alpha_exo 567..789 CDD:99819 49/247 (20%)
POLBc_alpha 852..1254 CDD:99915 132/431 (31%)
zf-DNA_Pol 1286..1459 CDD:286132 29/140 (21%)
POL3NP_010181.2 PTZ00166 90..1095 CDD:240301 293/1229 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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