Protein Alignment PolA1 and TIL1

DIOPT Version :10

• Sequence 1: NP_536736.2
• Gene: PolA1 / 42553
• FlyBaseID: FBgn0259113
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: NP_172303.5
• Gene: TIL1 / 837346
• AraportID: AT1G08260
• Length: 2161
• Species: Arabidopsis thaliana
• Alignment Length: 1441
• Identity: 261/1441 - (18%)
• Similarity: 471/1441 - (32%)
• Gaps: 512/1441 - (35%)

  Fly   271 LDDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKVAEKSAPKKET------TGSPKESESEDISRL 329
            :..|..:.|.:.|:.::|.....| ||...:||:......:.||      |.|....|..|..::
plant     1 MSGDNRRRDRKDTRWSKKPKVVNT-AEDELESKLGFGLFSEGETRLGWLLTFSSSSWEDRDTGKV 64

  Fly   330 LNNWESICQMDDDFEKSVLTTEQDSTISSDQQLRFWYWEAYEDPVKMPGEVFLFGR----TADGK 390
            .:     | :|..|     .|:...:..:..:.|.:::.|.:|.:::..|.:|..|    .||.:
plant    65 YS-----C-VDLYF-----VTQDGFSFKTKYKFRPYFYAATKDKMELELEAYLRRRYERQVADIE 118

  Fly   391 SVCLRVQNINRVLYLLPRQFLLDPISKEPTKQKVTV-ADIYKEFDSEVANQLKLEFFRSRKVTKS 454
            .|.....::...|..|.:::|  .||.:..:|.:.| .|:....:...|....||.:.|....|.
plant   119 IVEKEDLDLKNHLSGLQKKYL--KISFDTVQQLMEVKRDLLHIVERNQAKFDALEAYESILAGKR 181

  Fly   455 FAHHAIGIEVPQSCDYLEVHYDGKKPLPNLSADKKYNSIAHIFGATTNALERFLLDRKIKGPCWL 519
                   .:.||.|            |.::...::|:...|:         ||.:|..::...|.
plant   182 -------EQRPQDC------------LDSIVDLREYDVPYHV---------RFAIDNDVRSGQWY 218

  Fly   520 QVTGFKVSPTPMSWCNTEVTLTEPKNVELVQDKGKPAPPPPLTLLSLNVRTS----MNPKTSRNE 580
            .|          |..:|:|.|  .|..:|:|       ...:.:.:.::.|:    ..|....::
plant   219 NV----------SISSTDVIL--EKRTDLLQ-------RAEVRVCAFDIETTKLPLKFPDAEYDQ 264

  Fly   581 ICMISMLTHNRFHIDRPAPQPAFNRHMCALTRPAVVSWPLDLNF----EMAKYKSTTVHKHDSER 641
            |.|||.:...:..:              .:.|..|.....||.:    |...|...|..|::.|
plant   265 IMMISYMVDGQGFL--------------IINRECVGEDVEDLEYTPKPEFEGYFKVTNVKNEVE- 314

  Fly   642 ALLSWFLAQYQKIDADLIVTF--DSMDCQLNVITDQIVALKIPQWSRMGR------LRLSQSFGK 698
            .|..||. ..|::...:.||:  |..|                 |..:.|      :::::..|.
plant   315 LLQRWFY-HMQELKPGIYVTYNGDFFD-----------------WPFIERRASHHGIKMNEELGF 361

  Fly   699 RLLEHFVGRMVCDVKRSAEECIRAR--------------------SYDLQTLCKQVLKLKESERM 743
            |          ||  ::..|| ||:                    |:.|:.:.|..|..   :.:
plant   362 R----------CD--QNQGEC-RAKFACHLDCFAWVKRDSYLPQGSHGLKAVTKAKLGY---DPL 410

  Fly   744 EVNADDLLEM-YEKGESITKLISLTMQD--NSYLLRLMCELNIMPLALQITNICGNTMTRTLQGG 805
            |||.:|::.. .||.::   :.|.::.|  .:|.| .|..:|  |....:..|........|:.|
plant   411 EVNPEDMVRFAMEKPQT---MASYSVSDAVATYYL-YMTYVN--PFIFSLATIIPMVPDEVLRKG 469

  Fly   806 RSERNEFLLLHAFHEKNYIVPDKKPV------------SKRSGAGDTDATLSG---ADATMQTKK 855
            .....|.||:...::.|.:.|:|...            |:....|..:...||   :|.....|.
plant   470 SGTLCEMLLMVEAYKANVVCPNKNQADPEKFYQNQLLESETYIGGHVECLESGVFRSDIPTSFKL 534

  Fly   856 KAAYAGGLV-----------------------------------LEPMRG--LYEKYVLL--MDF 881
            .::....|:                                   ||.:|.  :.|:..|:  :|.
plant   535 DSSAYQQLIDNLGRDLEYAITVEGKMRMDSISNYDEVKDEIKEKLEKLRDDPIREEGPLIYHLDV 599

  Fly   882 NSLYPSIIQEYNICFTTVQQP--VDADELPTLPDSKTEPGILPLQ-------------------- 924
            .::||      ||..|...||  :..||:.|..|. ..||...|:
plant   600 AAMYP------NIILTNRLQPPSIVTDEICTACDF-NRPGKTCLRKLEWVWRGVTFMGKKSDYYH 657

  Fly   925 LKRLVES-----------------------------------RKEVKKLMAAP------------ 942
            ||:.:||                                   :|..|:::..|
plant   658 LKKQIESEFVDAGANIMSSKSFLDLPKVDQQSKLKERLKKYCQKAYKRVLDKPITEVREAGICMR 722

  Fly   943 ------------------------------------------DLSPELQMQYHIRQMALKLTANS 965
                                                      ..:.::.:.|...|:|.|...||
plant   723 ENPFYVDTVRSFRDRRYEYKTLNKVWKGKLSEAKASGNSIKIQEAQDMVVVYDSLQLAHKCILNS 787

  Fly   966 MYGCLGFAHSRFFAQHLAALVTHKGREILTNTQQLVQK--------------------------- 1003
            .||.:....:|:::..:|.:||:.|.:|:.|.:.|:::
plant   788 FYGYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWCCLPGSFPENFTFK 852

  Fly  1004 --------MNYDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVNKLYK-----QLELDIDGVFG 1055
                    ::|..|..:.|....|||    ||.    ..:...|.|.||     .:|.::||.:.
plant   853 TIDMKKLTISYPCVMLNVDVAKNNTN----DQY----QTLVDPVRKTYKSHSECSIEFEVDGPYK 909

  Fly  1056 CLL--------LLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSE 1112
            .::        :|.||:||..    :..|.|   .|.||.:|.||...:|..:....:.|:.|..
plant   910 AMIIPASKEEGILIKKRYAVF----NHDGTL---AELKGFEIKRRGELKLIKVFQAELFDKFLHG 967

  Fly  1113 KPLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQVALRMNR---- 1173
            ..|||...||.|        :|:..:.|        |....::.|:|..|.::..:..|::
plant   968 STLEECYSAVAA--------VADRWLDL--------LDNQGKDIADSELLDYISESSTMSKSLAD 1016

  Fly  1174 ------------ERNRRY-------KKGDMVDYVICLDG---------------TTNAAMQRAYH 1204
                        :|...:       .||....|::..:.               |||..:.: :|
plant  1017 YGEQKSCAVTTAKRLAEFLGVTMVKDKGLRCQYIVACEPKGTPVSERAVPVAIFTTNPEVMK-FH 1080

  Fly  1205 LDE-LKTSEDK--KLQLDTNYY---LGHQIHPVVT---RMVEVLEGTDASRIAECLGMD------ 1254
            |.: .|||.|.  :|.:|.:||   |...|..|:|   .|.:|     |:.:...|..|
plant  1081 LRKWCKTSSDVGIRLIIDWSYYKQRLSSAIQKVITIPAAMQKV-----ANPVPRVLHPDWLHKKV 1140

  Fly  1255 ---PTKFRQNAQRTQRENTEQSEGESLLKTTLQLYR--------LCEPFRFQCVTCKTEQLMASA 1308
               ..|||   ||...:....:..:.:|.|.|.:.:        .|:..|   .:.|..:.:|.:
plant  1141 REKDDKFR---QRKLVDMFSSANKDVVLDTDLPVTKDNVEDIEDFCKENR---PSVKGPKPIARS 1199

  Fly  1309 YRPGPSNSHIAVLQQCAKSECQTAPIQYLASVRNQLQLSMRQYVQRFYKNWLVCDHPDCNFNTRT 1373
            |......|      :|.:.|........::.......::.:.:::...:.|.|
plant  1200 YEVNKKQS------ECEQQESWDTEFHDISFQNIDKSVNYQGWLELKKRKWKV------------ 1246

  Fly  1374 HSLRKKSHRPL 1384
             :|.||..|.|
plant  1247 -TLEKKKKRRL 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA1	NP_536736.2	pol2	52..1237	CDD:273159	234/1275 (18%)
		zf-DNA_Pol	1286..1459	CDD:462651	15/107 (14%)
TIL1	NP_172303.5	DNA_pol_B_exo1	72..400	CDD:397292	77/427 (18%)
		DNA_polB_epsilon_exo	240..444	CDD:99822	47/256 (18%)
		POLBc_epsilon	505..1122	CDD:99918	116/655 (18%)
		DUF1744	1489..1872	CDD:462493