DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-alpha180 and REV3L

DIOPT Version :9

Sequence 1:	NP_536736.2	Gene:	DNApol-alpha180 / 42553	FlyBaseID:	FBgn0259113	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	XP_011534330.1	Gene:	REV3L / 5980	HGNCID:	9968	Length:	3157	Species:	Homo sapiens

Alignment Length:	1560	Identity:	318/1560 - (20%)
Similarity:	550/1560 - (35%)	Gaps:	414/1560 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VDDVYDVVDEREYAKRAQ----------EKYGDDWIEEDGTGYAEDLRDFFEDEDEYS------- 90
            |....|.:.|:....|:.          :....|||:    |:..  ::..:..|..:
Human  1765 VQQAEDCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQ----GHTR--KEMGQSLDSANTSFTAIL 1823

  Fly    91 ---DGE------EDRK--DSKKKKGVAPNSKKRPRENEKPVTGKAS---------IKNLFSNAVP 135
               |||      ||.:  .|:....:.|.....||....|...|..         :|.|.|  .|
Human  1824 SSPDGELVDVACEDLELYVSRNNDMLTPTPDSSPRSTSSPSQSKNGSFTPRTANILKPLMS--PP 1886

  Fly   136 KKMDVKTSVKDDDILADILGE-IKEEPAATSEKAEKV-----IAPAKISVTSRKFDAAAAKEYMN 194
            .:.::..::.|.|:...|..| ....|:...||..::     :...:::....:|:...:.|.:.
Human  1887 SREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLANDLAEFEGDFSLEGLR 1951

  Fly   195 SFLNNIKVQEQERKKAE------------ASSDNEMLER---ILKPKAAVPNTKV------AFFS 238
            .:........|..:...            :|:..:|:|.   ::.|....|:.::      |...
Human  1952 LWKTAFSAMTQNPRPGSPLRSGQGVVNKGSSNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEE 2016

  Fly   239 SPTIKKEPMPEKTPAKKATED----------PFSDNEMDFS-CL--DDDENQFDVEKTQ---QTE 287
            ....||.|..:.|...|:.|:          |....:||.| |:  .....:.||:.:|   |..
Human  2017 YERSKKLPKTKPTGVVKSAENFSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAP 2081

  Fly   288 KVSQTKTAAEKTSQSKVAEKSAPKKETTGSPKE--SESEDISRLLNNWESICQMDDDFEKSVLTT 350
            ....::||:|......||..|.|:|:.......  |.|...|.::..|:.....|     |....
Human  2082 TTGCSQTASESQMLPPVASASDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPD-----SKALN 2141

  Fly   351 EQDSTISSDQQLRFWYWEAYEDPVK---------MPGEVFLF------GRTADGKSVCLRVQNI- 399
            ..|...|..::|....:|.:..|:|         .|.|..:.      .||...:|:|.....|
Human  2142 GDDRPSSPVEELPSLAFENFLKPIKDGIQKSPCSEPQEPLVISPINTRARTGKCESLCFHSTPII 2206

  Fly   400 -NRVLYLLPRQFLLDPISKEPTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAIGIE 463
             .::|..||....|.|:|.||..||:
Human  2207 QRKLLERLPEAPGLSPLSTEPKTQKL--------------------------------------- 2232

  Fly   464 VPQSCDYLEVHYDGKKPLPNLSADKKYNSIAHIFGATTNALERFLLDR----------------K 512
                                  ::||        |:.|:.|.|.||.:                :
Human  2233 ----------------------SNKK--------GSNTDTLRRVLLTQAKNQFAAVNTPQKETSQ 2267

  Fly   513 IKGPCWLQVTGFKVSPTPMSWCNTEVTLTEPKNVELVQDKGKPAPPPPLTLLSLNV----RTSMN 573
            |.||......|||||..         .|.|.|.:..:|:         |||:|:.:    |..:.
Human  2268 IDGPSLNNTYGFKVSIQ---------NLQEAKALHEIQN---------LTLISVELHARTRRDLE 2314

  Fly   574 PKTSRNEICMISMLTHNRFHIDRPAP----------------QPAFNRHM----CALTRPAV--- 615
            |....:.||.:.....:    |.|.|                :..|::.:    ..|.|..:
Human  2315 PDPEFDPICALFYCISS----DTPLPDTEKTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGL 2375

  Fly   616 -VSWPLD---LNFEMAKYKSTTVHKHDS--ERALLSWFLAQYQK---IDADLIVTFDSMDCQLNV 671
             |::..|   |..|:|.......|:|..  :.....:|..|.::   .|.|:::.::........
Human  2376 EVTYAADEKALFHEIANIIKRGCHQHVRCFQYPHFFYFCKQLRERNMYDPDILLGYEIQMHSWGY 2440

  Fly   672 ITDQIVALKIPQWSRMGRL---RLSQSFGKRLLEH---------FVGRMVCDVKRSAEECIRARS 724
            :..:..||.|.....:.|:   ::...|.....|:         .|||:..::.|.....:...:
Human  2441 LLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTN 2505

  Fly   725 YDLQTLCKQVLKLKESERMEVNADDLLEMYEKGESITKLISLTMQDNSYL------LRLMCELNI 783
            |..:.:...||    .:|..:....:|.  :..::.|.|....|.|: |:      |:::.:|::
Human  2506 YTFENVSFHVL----HQRFPLFTFRVLS--DWFDNKTDLYRWKMVDH-YVSRVRGNLQMLEQLDL 2563

  Fly   784 MPLALQITNICGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPDKKPVSKRSGAGDTDATLSGAD 848
            :....::..:.|......|..|...|.|.::|......||| |....|.:||
Human  2564 IGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYI-PVTPSVQQRS------------- 2614

  Fly   849 ATMQTKKKAAYAGGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTT----VQQPVDADE-- 907
                 :.:|.....|::||....|...||::||.||||||:..||.||:|    |:.....||
Human  2615 -----QMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFK 2674

  Fly   908 -----LPTLPD--------------------SKTEPGILPLQLKRLVESRKEVKKLMAAPDLSPE 947
                 |...||                    .....|:||..|:.::::|..||:.|.|......
Human  2675 FGCTSLRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRA 2739

  Fly   948 LQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQ----HLAALVTHKGREILTNTQQLV---QKMN 1005
            |......||:.|||.||..:   |:..:.|..:    .:...:.||.||.|....:||   :|..
Human  2740 LSRMLDARQLGLKLIANVTF---GYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWG 2801

  Fly  1006 YDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVNKLY-KQLELDIDGVF-GCLLLLKKKKYAAI 1068
            ..||||||||:.:.......:|.:|||..|.::|.... |.::|..:.|: .|:|..||:....:
Human  2802 ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKRYVGYM 2866

  Fly  1069 KLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSEKPLEEKLD--AVHAQLEKIKT 1131
            ..:.|.|..:   .:.||::.|||| |..||   ..:|:..|  |.|.|..|  .:...:::...
Human  2867 YETLDQKDPV---FDAKGIETVRRD-SCPAV---SKILERSL--KLLFETRDISLIKQYVQRQCM 2922

  Fly  1132 QIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQVALRM-NRERNRRYKKGDMVDYVICLDGTT 1195
            ::.||...:..|:..|:. |....|...|.:|.:::..:| ..:|....:.|:.|.||| :.||.
Human  2923 KLLEGKASIQDFIFAKEY-RGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVI-IYGTP 2985

  Fly  1196 NAAMQRAYHLDELKTSEDKKLQLDTNYYLGHQIHPVVTRMVEVLEGTDASRIAECLGMDPTKFRQ 1260
            ...:.:... ..::..:|..|:|:..||:..||.|.:            :||...:|:|...:..
Human  2986 GVPLIQLVR-RPVEVLQDPTLRLNATYYITKQILPPL------------ARIFSLIGIDVFSWYH 3037

  Fly  1261 NAQRTQR-ENTEQSEGESLLKTTLQLYRLCEPFRFQCVTCK--TEQLMASAYRPGPSNSHIAVL- 1321
            ...|..: .::.:||.|....|..|.:.     ...|..|.  |:..:.|..|..|  .|:||:
Human  3038 ELPRIHKATSSSRSEPEGRKGTISQYFT-----TLHCPVCDDLTQHGICSKCRSQP--QHVAVIL 3095

  Fly  1322 ---------QQ-------------------CAKSECQTAPIQY-LASVRNQLQLS--MRQYVQRF 1355
                     ||                   |....|   |:.: |:.|..:|..:  :||.:.:|
Human  3096 NQEIRELERQQEQLVKICKNCTGCFDRHIPCVSLNC---PVLFKLSRVNRELSKAPYLRQLLDQF 3157

Fly 1356 1355
Human 3158 3157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha180	NP_536736.2	DNA_pol_alpha_N	24..83	CDD:289058	8/49 (16%)
		pol2	52..1237	CDD:273159	286/1396 (20%)
		DNA_polB_alpha_exo	567..789	CDD:99819	43/275 (16%)
		POLBc_alpha	852..1254	CDD:99915	119/444 (27%)
		zf-DNA_Pol	1286..1459	CDD:286132	20/104 (19%)
REV3L	XP_011534330.1	DUF4683	748..1134	CDD:292363
		DNA_polB_zeta_exo	2295..2559	CDD:99821	47/283 (17%)
		POLBc	2317..2818	CDD:214691	115/533 (22%)
		POLBc_zeta	2585..3033	CDD:99917	131/493 (27%)
		DNA_pol_B	2585..3032	CDD:278562	130/492 (26%)
		zf-C4pol	3069..3136	CDD:290959	14/71 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810